Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Ghoneim, Enass M.; El-Attar, Mona A.; Hammam, Essam; Khashaba, Pakinaz Y.

doi:10.1016/j.jpba.2006.09.025

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…It is only the organomercury compounds (not formed under controlled laboratory conditions) are toxic [31]. There are many works have been announced for the authors based on the use of Hg electrodes [1,[24][25][26]29]. Also, Petr Zuman [31] worked on daily with Hg for many years with no ill health effects, but he met during his life at least 500 polarographers who lived and worked in laboratories.…”

Section: Solutions and Methodology (I)mentioning

confidence: 99%

“…The electrochemical experiments, weighing the solid materials, the used deionized water and convective transport during the preconcentration step were performed using the same equipment that described in the refs. [1,[24][25][26]]. An automatic micropipette (Eppendorf-Multipette® plus) was used to transferring analyte solutions.…”

Section: Apparatusmentioning

confidence: 99%

“…It is a potent second generation sulphonylurea with similar action of glipizide (GP) [1] (previous our reported work), which an orally active hypoglycemic agent that reduces the blood-sugar concentration in patients with kind II non-insulin based on diabetes mellitus for long acting. GBC has a greater effect in lowering fasting blood glucose and elevating fasting plasma insulin levels than GP.…”

Section: Introductionmentioning

confidence: 98%

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Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

El-Attar

Ghoneim

2020

Egypt. J. Chem.

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The electrochemical behavior of anti-hyperglycemic (glibenclamide, GBC) was investigated and discussed at HMDE in Britton-Robinson universal buffer using cyclic voltammetry. Its voltammogram at pH values 6-11 displayed a quasi-reversible redox couple one-electron peak corresponding to a catalytic hydrogen process. Based on this voltammetric peak, a validated and sensitive SW-AdCS voltammetric method was depicted for determination of GBC in the bulk form, diabetic drug (Daonil  5 mg) and in human serum. The (LOD) of 6×10 -9 M (2.964 ng mL 1 ) and (LOQ) of 2×10 8 M (9.88 ng mL 1 ) bulk GBC were achieved, respectively, While for protein-free GBC-spiked human serum were (LOD) of 1.5x10 -8 M (7.41 ng mL -1 ) and limit of quantification (LOQ) of 5x10 -8 M (24.7 ng mL -1 ), respectively. The described analytical method was utilized to estimate the pharmacokinetic parameters of GBC in plasma of hospitalized volunteers after the administration of a single oral dose of Daonil  5 mg (p  0.05).

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Section: Solutions and Methodology (I)mentioning

confidence: 99%

Section: Apparatusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

El-Attar

Ghoneim

2020

Egypt. J. Chem.

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“…European Pharmacopeia [20] describes a titrimetric assay in which drug in dimethyl formamide is titrated with lithium methoxide using quinaldine red as indicator. Methods based on numerous other techniques have been suggested for the determination of GPZ in pharmaceuticals including, uv-spectrophotometry [21][22][23][24], UPLC [25,26], TLC [27,28], HPTLC [29] and voltammetry [30].…”

Section: Glipizidementioning

confidence: 99%

Rapid and Reliable Determination of Glipizide in Pharmaceutical Samples by HPLC and Its Degradation Study

Basavaiah¹

2017

Austin J Anal Pharm Chem

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A simple, specific and rapid high-performance liquid chromatographic (HPLC) method for the determination of glipizide (GPZ) in pharmaceutical sample is described. Reversed phase chromatography was performed on an Inertsil ODS 3V (150 × 4.6mm; 5µm particle size) column with an isocratic mobile phase consisting of 10mM potassium dihydrogen phosphate (pH 3.9) and methanol (60:40 v/v). The effluent was monitored on a uv detector at 220nm and the column temperature was maintained at 35ᴼC. Linear response (r=0.9999) was observed over the range, 1-450µgmL -1 ; and the limits of detection (LOD) and quantification (LOQ) were calculated to be 0.03 and 0.09 µgmL -1 , respectively. Both intra-day and inter-day precisions at three tested concentrations were excellent, with %RSD values of <1% and the accuracy was better than 1.5% (RE). The method was also validated for robustness, ruggedness and selectivity and the results were satisfactory. The method was applied to the determination of GPZ in tablets and the results agreed well with the label claim and those obtained by European Pharmacopeial method. Entire assay was complete in less than 10min. As part of degradation study, the drug was subjected to acid-, base-, peroxide-, heat-, and light-induced stress conditions, and the drug was found to be susceptible to degradation under oxidation, and inert to other conditions.

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“…GL lowers blood glucose concentration by stimulating the pancreas to secrete insulin and in helping the body use insulin efficiently. [9][10][11] Subsequent research work revealed that GL has a good general tolerability, comparatively low incidence of hypoglycemia and low rate of secondary failure. In addition, GL has potential for slowing the progression of diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

A pH‐sensitive chitosan‐tripolyphosphate hydrogel beads for controlled glipizide delivery

Sun

et al. 2011

J Biomed Mater Res

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A chitosan(CS)-tripolyphosphate (TPP) hydrogel bead was prepared by the ionic gelation method for the controlled delivery of glipizide. The structure and surface morphology of the beads were characterized by FT-IR and SEM, separately. Factors influencing the swelling behavior of the hydrogel beads were also investigated, such as CS concentration (X(1)), TPP concentration (X(2)), the weight ratio of drug to polymer (X(3)), crosslinking time (X(4)), and the volume ratio of CS to TPP (X(5)). In addition, the swelling property and the delivery behavior of the hydrogel bead was studied as well. With decreasing of pH value, the swelling ratio of the bead was increasing. The swelling ratio of hydrogel bead at pH 1.5 was relatively high, while this value was low at pH 6.8. The amount of glipizide released from the hydrogel bead at pH 1.5 was about 90%, while this value approached 36% at pH 6.8. The results clearly suggested that the CS-TPP hydrogel beads were used as a pH-sensitive controlled release system for the delivery of glipizide.

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Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Cited by 13 publications

References 14 publications

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

Rapid and Reliable Determination of Glipizide in Pharmaceutical Samples by HPLC and Its Degradation Study

A pH‐sensitive chitosan‐tripolyphosphate hydrogel beads for controlled glipizide delivery

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