Strigolactones: Phytohormones with Promising Biomedical Applications

Prandi, Cristina; Kapulnik, Yoram; Koltai, Hinanit

doi:10.1002/ejoc.202100204

Cited by 12 publications

(6 citation statements)

References 56 publications

(85 reference statements)

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“…In our experiment, the content of JA in the treatment groups was lower than that of the control group, indicating that small peptides and surfactants could down-regulate the expression of JA and delay the senescence of tea plants under high-temperature stress, playing a protective role on tea leaves. SL is also widely involved in plant stress [54][55][56][57][58][59]. Our results showed that small peptides and surfactants down-regulate the expression of SL and enhance the adaptability of tea plants under high-temperature stress.…”

Section: Discussionmentioning

confidence: 61%

Enhancing the Adaptability of Tea Plants (Camellia sinensis L.) to High-Temperature Stress with Small Peptides and Biosurfactants

Chen,

Song,

et al. 2023

Plants

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Tea plants are highly susceptible to the adverse effects of a high-temperature climate, which can cause reduced yield and quality and even lead to plant death in severe cases. Therefore, reducing the damage caused by high-temperature stress and maintaining the photosynthetic capacity of tea plants is a critical technical challenge. In this study, we investigated the impact of small oligopeptides (small peptides) and surfactants on the high-temperature-stress tolerance of tea plants. Our findings demonstrated that the use of small peptides and surfactants enhances the antioxidant capacity of tea plants and protects their photosynthetic system. They also induce an increase in gibberellin (GA) content and a decrease in jasmonic acid (JA), strigolactone (SL), auxin (IAA), and cytokinin (CTK) content. At the same time, small peptides regulate the metabolic pathways of diterpenoid biosynthesis. Additionally, small peptides and surfactants induce an increase in L-Carnosine and N-Glycyl-L-Leucine content and a decrease in (5-L-Glutamyl)-L-Amino Acid content, and they also regulate the metabolic pathways of Beta-Alanine metabolism, Thiamine metabolism, and Glutathione metabolism. In summary, small peptides and surfactants enhance the ability of tea plants to resist high-temperature stress.

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Section: Discussionmentioning

confidence: 61%

Enhancing the Adaptability of Tea Plants (Camellia sinensis L.) to High-Temperature Stress with Small Peptides and Biosurfactants

Chen,

Song,

et al. 2023

Plants

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“…PPIC is a cyclophilin which plays different roles in human health [54] , [55] , [75] . Antiviral and anticancer activities of natural or synthetic strigolactones have been documented [76] , [77] . Also, the activity of stereo-defined strigolactones has been acknowledged for high cancer cell specificity in humans [77] , [78] .…”

Section: Resultsmentioning

confidence: 99%

On the human health benefits of microalgal phytohormones: An explorative in silico analysis

Mondo

Vinaccia

Pistelli

et al. 2023

Computational and Structural Biotechnology Journal

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“…SLs are multifunctional plant metabolites acting as a class of hormones controlling plant developmental processes and interactions with other organisms (Lopez‐Raez et al ., 2017 ; Lanfranco et al ., 2018b ; Carvalhais et al ., 2019 ); they were even shown to have an impact on human cell lines as anticancer, anti‐inflammatory and antiviral drugs (Prandi et al ., 2021 ). SLs have therefore multiple target organisms, which, in turn, had to evolve a molecular machinery to perceive and respond to them.…”

Section: Discussionmentioning

confidence: 99%

A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica

et al. 2022

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 Strigolactones (SLs) are plant hormones and important signaling molecules required to promote the arbuscular mycorrhizal (AM) symbiosis. While in plants an /-hydrolase, DWARF14 (D14), was shown to act as a receptor that binds and cleaves SLs, the fungal receptor for SLs is unknown.  Since AM fungi are currently not genetically tractable, in this study, we used the fungal pathogen Cryphonectria parasitica for which gene deletion protocols exist, as a model, as we have previously shown that it responds to SLs. By means of computational, biochemical and genetic analyses we identified a D14 structural homologue, CpD14.  Molecular homology modelling and docking support the prediction that CpD14 interacts with and hydrolyses SLs. The recombinant CpD14 protein shows / hydrolytic activity in vitro against the SLs synthetic analogue GR24; its enzymatic activity requires an intact Ser/His/Asp catalytic triad. CpD14 expression in the d14-1 loss-offunction Arabidopsis thaliana line did not rescue the plant mutant phenotype. However, gene inactivation by knock-out homologous recombination reduced fungal sensitivity to SLs.  These results indicate that CpD14 is involved in SLs responses in C. parasitica and strengthen the role of SLs as multifunctional molecules acting in plant microbe-interactions.

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Strigolactones: Phytohormones with Promising Biomedical Applications

Cited by 12 publications

References 56 publications

Enhancing the Adaptability of Tea Plants (Camellia sinensis L.) to High-Temperature Stress with Small Peptides and Biosurfactants

Enhancing the Adaptability of Tea Plants (Camellia sinensis L.) to High-Temperature Stress with Small Peptides and Biosurfactants

On the human health benefits of microalgal phytohormones: An explorative in silico analysis

A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica

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