Stricturing Crohn’s disease-like colitis in a patient treated with belatacept

Bozon, Anne; Jeantet, Guillaume; Rivière, Benjamin; Funakoshi, Natalie; Dufour, Gaspard; Combes, R; Valats, Jean-Christophe; Delmas, Sylvie; Serre, Jean Emmanuel; Bismuth, Michaël; Ramos, Jeanne; Quintrec, Moglie Le; Chambrun, Guillaume Pineton de

doi:10.3748/wjg.v23.i48.8660

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…No data regarding the impact of this treatment on the GM have been published so far. However, a recent case report relates the occurrence of severe intestinal lesions (Crohn‐like colitis) induced by belatacept 129 . The possible role of the GM in this complication needs to be explored.…”

Section: Belataceptmentioning

confidence: 99%

Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

Gabarre

Loens

Tamzali

et al. 2022

American Journal of Transplantation

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The gut microbiota (GM) is the total microbial mass that colonizes the digestive tract of a host. It is composed of trillions of bacteria, viruses, archaea, and fungi that are distributed throughout the digestive tract with different abundances. 1,2 Our knowledge of the GM has dramatically increased over the last few decades principally because of the development of new genetic tools. 3 Solid organ transplantation (SOT) can only be considered medically when accompanied by the long-term use of immunosuppressive treatments (IST) to avoid graft rejection. However, ISTs are

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Section: Belataceptmentioning

confidence: 99%

Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

Gabarre

Loens

Tamzali

et al. 2022

American Journal of Transplantation

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“…3 Krummey and Cheeseman 4 demonstrated that interleukin 17-secreting T helper (Th17) cells are especially sensitive to CTLA-4 coinhibition and resistant to costimulation blockade. Psoriasis and inflammatory bowel disease, for which a belatacept-induced case has been recently reported, 5 are both Th17 mediated.…”

Section: Belatacept and Autoimmune Adverse Eventsmentioning

confidence: 99%

Belatacept and Autoimmune Adverse Events

Ville

Cantarovich

2018

Transplantation

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considering the lack of similar reports of HBVr in large cohorts of anti-HBc-positive LT patients treated for HCV recurrence, clinicians should be aware of this rare phenomenon and evaluate patients with alanine aminotransferase flare for HBVr even in the long term after DAA treatment. FIGURE 1. HBV reactivation after DAA (case 1) or IFN (case 2)-based therapy of recurrent hepatitis C in 2 anti-HBc-positive LT recipients.

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Organ Toxicity by Immunosuppressive Drugs in Solid Organ Transplantation

Dugbartey

Şener

2022

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

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Stricturing Crohn’s disease-like colitis in a patient treated with belatacept

Cited by 5 publications

References 10 publications

Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

Belatacept and Autoimmune Adverse Events

Organ Toxicity by Immunosuppressive Drugs in Solid Organ Transplantation

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