Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk

Karcher, Nicole R.; Hua, Jessica P.Y.; Kerns, John G.

doi:10.1038/s41386-019-0455-z

Cited by 3 publications

(1 citation statement)

References 61 publications

(87 reference statements)

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“…Specific decreases in lose-shift probability have been found at 80:40, but not at 80:20, in those with early psychosis ( 47 ), which features increased dopamine function in the associative striatum (DMS equivalent in humans) ( 7 , 15 ). In addition, imaging studies in those at risk of developing psychosis (those with high levels of subthreshold psychotic symptoms) have observed altered caudate activation in response to unexpected feedback during PRL ( 66 ). The specific effects of amphetamine and DMS activation on lose-shift, but not win-stay, probability was unexpected.…”

Section: Discussionmentioning

confidence: 99%

Activity in the Dorsomedial Striatum Underlies Serial Reversal Learning Performance Under Probabilistic Uncertainty

Young

Das

Zou

et al. 2023

Biological Psychiatry Global Open Science

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Section: Discussionmentioning

confidence: 99%

Activity in the Dorsomedial Striatum Underlies Serial Reversal Learning Performance Under Probabilistic Uncertainty

Young

Das

Zou

et al. 2023

Biological Psychiatry Global Open Science

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A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

et al. 2020

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Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to emotional stimuli in the striatum and medial temporal lobe. Using a randomised, double-blind, parallel-group design, 33 CHR patients were randomised to a single oral dose of CBD (600 mg) or placebo. Healthy controls (n = 19) were studied under identical conditions but did not receive any drug. Participants were scanned with functional magnetic resonance imaging (fMRI) during a fearful face-processing paradigm. Activation related to the CHR state and to the effects of CBD was examined using a region-of-interest approach. During fear processing, CHR participants receiving placebo (n = 15) showed greater activation than controls (n = 19) in the parahippocampal gyrus but less activation in the striatum. Within these regions, activation in the CHR group that received CBD (n = 15) was intermediate between that of the CHR placebo and control groups. These findings suggest that in CHR patients, CBD modulates brain function in regions implicated in psychosis risk and emotion processing. These findings are similar to those previously evident using a memory paradigm, suggesting that the effects of CBD on medial temporal and striatal function may be task independent.

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Linking Salience Signaling With Early Adversity and Affective Distress in Individuals at Clinical High Risk for Psychosis: Results From an Event-Related fMRI Study

Millman

Schiffman

Gold

et al. 2022

Schizophrenia Bulletin Open

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Evidence suggests dysregulation of the salience network in individuals with psychosis, but few studies have examined the intersection of stress exposure and affective distress with prediction error (PE) signals among youth at clinical high-risk (CHR). Here, 26 individuals at CHR and 19 healthy volunteers (HVs) completed a monetary incentive delay task in conjunction with fMRI. We compared these groups on the amplitudes of neural responses to surprising outcomes – PEs without respect to their valence – across the whole brain and in two regions of interest, the anterior insula and amygdala. We then examined relations of these signals to the severity of depression, anxiety, and trauma histories in the CHR group. Relative to HV, youth at CHR presented with aberrant PE-evoked activation of the temporoparietal junction and weaker deactivation of the precentral gyrus, posterior insula, and associative striatum. No between-group differences were observed in the amygdala or anterior insula. Among youth at CHR, greater trauma histories were correlated with stronger PE-evoked amygdala activation. No associations were found between affective symptoms and the neural responses to PE. Our results suggest that unvalenced PE signals may provide unique information about the neurobiology of CHR syndromes and that early adversity exposure may contribute to neurobiological heterogeneity in this group. Longitudinal studies of young people with a range of risk syndromes are needed to further disentangle the contributions of distinct aspects of salience signaling to the development of psychopathology.

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Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk

Cited by 3 publications

References 61 publications

Activity in the Dorsomedial Striatum Underlies Serial Reversal Learning Performance Under Probabilistic Uncertainty

Activity in the Dorsomedial Striatum Underlies Serial Reversal Learning Performance Under Probabilistic Uncertainty

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Linking Salience Signaling With Early Adversity and Affective Distress in Individuals at Clinical High Risk for Psychosis: Results From an Event-Related fMRI Study

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