Striatonigral level of neurochemical organization of avoidance conditioned reflexes of various complexity

Suvorov, N. F.; Saul’skaya, N. B.; Chivileva, O. G.

doi:10.1007/bf01150020

Cited by 4 publications

(2 citation statements)

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“…The results of the investigations showed that the capacity for learning influences the content of metabolism of DA in the nigrostriatal system. This does not contradict published data which indicate that the metabolism of DA in this region of the brain alters during the formation and performance of conditioned reflexes [5,7]. Nevertheless, the comparative investigation undertaken in this study of learning-capable and incapable animals poses a number of new questions.…”

Section: Resultscontrasting

confidence: 48%

“…Convincing data have been obtained regarding change in the content and metabolism of dopamine, a principal mediator of the nigrostriatal system, in the realization of conditioned reflex habits of varying degrees of complexity [5,7]. At the same time, data on the functioning of the corticostriatal system in the process of learning and the performance of learned reactions are few in number.…”

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confidence: 99%

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Influence of glutamate on the content and metabolism of dopamine in the nigrostriatal system of rats distinguished by capacity for learning

Karpova

Yakimovskii

1994

Neurosci Behav Physiol

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The effect of repeated (over the course of nine days) intrastriatal microinjections of glutamate (5 or 0.5 micrograms in 0.75 microliters of physiological solution daily) were investigated in 42 male Sprague-Dawley rats. Twenty-nine rats were preliminarily trained in a Skinner box using food reinforcement. It was demonstrated that the administration of glutamate to rats not subjected to training increases the content of homovanillic acid in the striatum. A similar influence in rats that are capable of learning leads to an increase in the content of dopamine and a decrease in the level of homovanillic acid in this nucleus, while it does not induce changes in the biochemical indicators under investigation in those rats that are incapable of learning. Microinjections of glutamate also do not alter the capacity for learning in any of the groups of animals. The possible causes for the different influence of intrastriatal microinjections of glutamate on the activity of the nigrostriatal system of rats differing by capacity for learning are discussed.

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Section: Resultscontrasting

confidence: 48%

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confidence: 99%