Striated Muscle Fibers: Inactivation of Contraction Induced by Shortening

Taylor, Stuart R.; Rüdel, Reinhardt

doi:10.1126/science.167.3919.882

Cited by 118 publications

(52 citation statements)

References 16 publications

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“…Finally, analyses of the ATP hydrolysis of foreshortened muscles are not measurements of the activation metabolism per se as such measurements must include an energy consumption due to residual actomyosin interaction. Further, Taylor & Rudel (1970) have suggested that at sarcomere lengths less than 1-6 ,u the activation mechanism is inhibited. Tension-related heat.…”

Section: Discussionmentioning

confidence: 99%

Activation heat, activation metabolism and tension‐related heat in frog semitendinosus muscles

Homsher¹,

Mommaerts²,

Ricchiuti³

et al. 1972

The Journal of Physiology

176

145

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SUMMARY1. Frog semitendinosus muscles were stretched to various lengths beyond the rest length (lo) and their initial heat and isometric tension production were measured.2. As the overlap between the thick and thin filaments is reduced, the initial twitch heat and tension decline in a linear manner. At a point at which the twitch tension approaches zero, the initial heat is 30 % of that seen at lo. It is concluded that this heat is the activation heat and reflects the energetics of calcium release and reaccumulation. The initial heat at shorter sarcomere lengths appears to be the sum of the activation heat plus a heat production associated with the interaction of the thick and thin filaments.3. A similar relationship between heat and tension production is seen in tetanic contractions.4. The time course of activation heat production in a twitch can be resolved into two phases: a temperature insensitive (Q10 < 1.3) 'fast' phase (with a time constant of 45 msec) and a temperature sensitive (Q10 = 2.8) 'slow' phase (with a time constant of 330 msec at 00 C).5. Measurements of the creatine phosphate (PC) hydrolysis by muscles contracting isometrically at various muscle lengths at and beyond lo, indicate an enthalpy change of -11-2 kcal/mole PC hydrolysed. The enthalpy change for the ATP hydrolysis by muscles stretched so that little or no tension was produced with stimulation was -9 9 kcal/mole ATP hydrolysed. It is concluded that the net activation heat is produced by the hydrolysis of PC or ATP.

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Section: Discussionmentioning

confidence: 99%

Activation heat, activation metabolism and tension‐related heat in frog semitendinosus muscles

Homsher¹,

Mommaerts²,

Ricchiuti³

et al. 1972

The Journal of Physiology

176

145

View full text Add to dashboard Cite

show abstract

“…A possibility worth considering would be that the relatively wide frog muscle fibers become incompletely activated during tetanic stimulation at short lengths because of decremental inward spread of activation as the fiber diameter expands with shortening (Taylor and Rüdel, 1970; however, see GonzalezSerratos, 1975). This would reduce the force output below the expected values along the ascending limb in the frog fibers.…”

Section: The Length-tension Relationshipmentioning

confidence: 99%

Contractile properties of mouse single muscle fibers, a comparison with amphibian muscle fibers

Edman

2005

Journal of Experimental Biology

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Single fibers, 25-40 µm wide and 0.5-0.7·mm long, were isolated from the flexor digitorum brevis muscle of the mouse. Force and movement were recorded (21-27°C) from the fiber as a whole and, in certain experiments, from a short marked segment that was held at constant length by feedback control. The maximum tetanic force, 368±57·kN/m 2 (N=10), was not significantly different from that recorded in frog muscle fibers at equal temperature. However, the rising phase of the tetanus was considerably slower in the mammalian fibers, 202±20·ms (N=17) being required to reach 90% of maximum tetanic force as compared with 59±4·ms (N=20) in the frog muscle fibers. Similar to the situation in frog muscle fibers, the force-velocity relation exhibited two distinct curvatures located on either side of a breakpoint near 80% of the isometric force. Maximum speed of shortening was 4.0±0.3·fiber·lengths·s

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“…Below the slack length, both isometric tension and speed of unloaded shortening fall off steeply, and although some of the features of this 18 A. F. HUXLEY MUSCULAR CONTRACTION decline seemed to be related to the length of the filaments (Gordon et al 1966b), it is now clear that a failure of inward spread of activation is at least part of the explanation (S. R. Taylor & RUdel, 1970; RUdel & S. R. ).…”

Section: Sliding Filamentsmentioning

confidence: 99%