Striatal Volume Abnormalities in Treatment-Naïve Patients Diagnosed with Pediatric Major Depressive Disorder

Matsuo, Koji; Rosenberg, David; Easter, Philip; MacMaster, Frank P.; Chen, Hua Hsuan; Nicoletti, Mark; Caetano, Sheila C.; Hatch, John P.; Soares, Jair C.

doi:10.1089/cap.2007.0026

Cited by 89 publications

(64 citation statements)

References 37 publications

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“…The GM regions detected here in juveniles with subthreshold depression have been implicated in the pathophysiology of depression in adults and adolescents, [9][10][11]14,29 and altered WM microstructure within tracts connecting these regions has been reported in adolescents with MDD. 37 Also, functional impairments within the reward system have been hypothesized to contribute to the onset of depressive disorders in adolescence.…”

Section: Discussionmentioning

confidence: 56%

“…The differences are more widespread in adolescents with MDD, since reduced gray matter volumes have been reported in frontal, limbic, and striatal regions such as prefrontal cortex (PFC), 9,10 ACC, 11 amygdala, 12 hippocampus, 13 and caudates. 9,14 A sex effect was reported in one study demonstrating smaller nucleus accumbens in girls with depression only, and increased growth of the amygdala during adolescence associated with depression in girls and decreased growth in boys. 15 A further step requires investigating the morphometry on the whole brain and assessing the clinical outcome of adolescents with subthreshold depression in order to shed light on the early brain structure variations involved in such emotional dysregulation and vulnerability to depressive disorders, including vulnerability related to sex.…”

Section: Introductionmentioning

confidence: 97%

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Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Vulser

Lemaître

Artiges

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 97%

Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Vulser

Lemaître

Artiges

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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“…Depression-associated differences in BG volumes are less consistent in samples of both younger adults 19,20 and adolescents. 21 It appears, therefore, that this discrepancy is associated with age differences in the study samples; that is, it is possible that only older individuals with MDD exhibit abnormally reduced putamen and caudate volumes. In this context, it is similarly possible that MDD-related BG volumetric reductions are associated with length of MDD history, a clinical characteristic that is likely to be associated with age.…”

Section: Introductionmentioning

confidence: 98%

“…Depression-associated differences in BG volumes are less consistent in samples of both younger adults 19,20 and adolescents. 21 It appears, therefore, that this discrepancy is associated with age differences in the study Background: Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG).…”

mentioning

confidence: 99%

Accelerated aging of the putamen in patients with major depressive disorder

Sacchet

Camacho

Livermore

et al. 2017

JPN

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IntroductionMajor depressive disorder (MDD) is primarily characterized by depressed mood and a blunted experience of pleasure (i.e., anhedonia). 1 The disorder is prevalent and chronic and represents a substantial personal, social and economic burden. [2][3][4] Neuroscience promises to elucidate mechanisms under lying depressive pathophysiology, leading to more effective approaches to the prevention and treatment of this debilitating disorder.Considerable evidence indicates that reward processing is dysfunctional in individuals with MDD. 5,6 The basal ganglia (BG) are a set of subcortical structures, including the striatum (caudate and putamen), nucleus accumbens and pallidum, that are critically involved in these reward processing steps. 7Previously research has indicated that depressed individuals have decreased activation in the striatum, 5,6 and some investigators have hypothesized that this abnormal activity affects decision-making. 5 Research in both animals and humans suggests that the dorsal striatum is involved in action selection and initiation and in encoding and integrating sensorimotor, cognitive and motivational/emotional information.8 Current evidence is mixed regarding specific roles of the putamen and caudate in reward processing. The results of several studies using fMRI suggest that whereas the putamen specifi cally encodes reward-related feedback, the caudate encodes both reward and punishment feedback.9,10 Finally, researchers have reported that the putamen is activated most strongly during anticipation of reward, whereas the caudate is activated most strongly during the receipt of reward. 8,10,11 A growing body of research indicates that adults with MDD have smaller volumes of the caudate 12-15 and putamen 13,14,16,17 than healthy controls. Postmortem studies have also reported smaller putamen volumes in depressed than in nondepressed adults. 18 It is important to note that these studies typically include adult samples with a mean age older than 40 years. Depression-associated differences in BG volumes are less consistent in samples of both younger adults 19,20 and adolescents. 21 It appears, therefore, that this discrepancy is associated with age differences in the study Background: Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG). Here we assessed age-related changes in BG volume in both patients with MDD and healthy control participants. Methods: We obtained whole-brain T 1 -weighted images from patients with MDD and healthy controls. We estimated grey matter volumes of the BG, including the nucleus accumbens, caudate, pallidum and putamen. Volumes were assessed using multivariate analysis of covariance (MANCOVA) with age as a covariate, followed by appropriate post hoc tests. Results: We included 232 individuals (116 patients with MDD) in our analy...

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“…Striatal alterations of these earlyonset patients might suggest that deficits of putaminal volumes might start from the onset of MDD. 30 Reduced brain activities of putamen toward reward stimuli are found in MDD patients, and reduced volumes of caudate were associated with severity of symptoms, which suggested that the basal ganglion might be responsible for hedonic motivation. 31 Our previous article also shows volumetric alterations of thalamus in the patients with MDD-and-PD, which also supports the findings in this study.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal and Subcortical Alterations of First-Episode, Medication-Naïve Major Depressive Disorder With Panic Disorder Patients

Lai¹

2014

JNP

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The authors conducted a subcortical analysis of first-episode, medication-naïve patients with major depressive disorder comorbid with panic disorder. A sample of 15 patients were compared with 15 healthy controls to explore volumetric differences of subcortical regions and hippocampus, including the putamen and thalamus. The patient group had smaller volumes of left hippocampus, thalamus, and putamen. Subcortical and hippocampal volumes in the patient group showed significant negative correlations with symptom severity. Structural alterations of the putamen, hippocampus, and thalamus might represent the structural pathophysiology of major depressive disorder comorbid with panic disorder.

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Striatal Volume Abnormalities in Treatment-Naïve Patients Diagnosed with Pediatric Major Depressive Disorder

Abstract: These findings provide fresh evidence for abnormalities in the striatum of medication-naïve pediatric MDD patients and suggest the possible involvement of the striatum in the pathophysiology of MDD.

Cited by 89 publications

References 37 publications

Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Accelerated aging of the putamen in patients with major depressive disorder

Hippocampal and Subcortical Alterations of First-Episode, Medication-Naïve Major Depressive Disorder With Panic Disorder Patients

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