Striatal pathology underlies prion infection-mediated hyperactivity in mice

Gunapala, Keith M.; Chang, Daniel; Hsu, Christine D.; Manaye, Kebreten F.; Drenan, Ryan M.; Switzer, Robert C.; Steele, Andrew D.

doi:10.4161/pri.4.4.13721

Cited by 7 publications

(5 citation statements)

References 60 publications

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“…Video-based activity data was analyzed using HomeCageScan 3.0; behavioral definitions were as described previously [34] , [35] . High intensity activity was defined as walking, jumping, rearing, and hanging behaviors.…”

Section: Methodsmentioning

confidence: 99%

Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

et al. 2014

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In rodents, daily feeding schedules induce food anticipatory activity (FAA) rhythms with formal properties suggesting mediation by food-entrained circadian oscillators (FEOs). The search for the neuronal substrate of FEOs responsible for FAA is an active area of research, but studies spanning several decades have yet to identify unequivocally a brain region required for FAA. Variability of results across studies leads to questions about underlying biology versus methodology. Here we describe in C57BL/6 male mice the effects of varying the ‘dose’ of caloric restriction (0%, 60%, 80%, 110%) on the expression of FAA as measured by a video-based analysis system, and on the induction of c-Fos in brain regions that have been implicated in FAA. We determined that more severe caloric restriction (60%) leads to a faster onset of FAA with increased magnitude. Using the 60% caloric restriction, we found little evidence for unique signatures of neuronal activation in the brains of mice anticipating a daily mealtime compared to mice that were fasted acutely or fed ad-libitum–even in regions such as the dorsomedial and ventrolateral hypothalamus, nucleus accumbens, and cerebellum that have previously been implicated in FAA. These results underscore the importance of feeding schedule parameters in determining quantitative features of FAA in mice, and demonstrate dissociations between behavioral FAA and neural activity in brain areas thought to harbor FEOs or participate in their entrainment or output.

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Section: Methodsmentioning

confidence: 99%

Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

et al. 2014

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“…Video-based activity data was analyzed using HomeCageScan 3.0 [29] , [40] , [41] ; behavioral definitions were as described previously [29] , [42] . High intensity activity was defined as walking, jumping, rearing, and hanging behaviors.…”

Section: Methodsmentioning

confidence: 99%

Food Anticipatory Activity Behavior of Mice across a Wide Range of Circadian and Non-Circadian Intervals

et al. 2012

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When rodents are fed in a limited amount during the daytime, they rapidly redistribute some of their nocturnal activity to the time preceding the delivery of food. In rats, anticipation of a daily meal has been interpreted as a circadian rhythm controlled by a food-entrained oscillator (FEO) with circadian limits to entrainment. Lesion experiments place this FEO outside of the light-entrainable circadian pacemaker in the suprachiasmatic nucleus. Mice also anticipate a fixed daily meal, but circadian limits to entrainment and anticipation of more than 2 daily meals, have not been assessed. We used a video-based behavior recognition system to quantify food anticipatory activity in mice receiving 2, 3, or 6 daily meals at intervals of 12, 8, or 4-hours (h). Individual mice were able to anticipate as many as 4 of 6 daily meals, and anticipation persisted during meal omission tests. On the 6 meal schedule, pre-prandial activity and body temperature were poorly correlated, suggesting independent regulation. Mice showed a limited ability to anticipate an 18 h feeding schedule. Finally, mice showed concurrent circadian and sub-hourly anticipation when provided with 6 small meals, at 30 minute intervals, at a fixed time of day. These results indicate that mice can anticipate feeding opportunities at a fixed time of day across a wide range of intervals not previously associated with anticipatory behavior in studies of rats. The methods described here can be exploited to determine the extent to which timing of different intervals in mice relies on common or distinct neural and molecular mechanisms.

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“…Following the video recordings, the mice are transported back to the husbandry room, recaged, and provided with their respective meal. Video recordings were analyzed with HomeCageScan 3.0 (Cleversys, Inc.) [14] , [40] , [41] . Behaviors were defined as described previously [13] , [15] , [18] ; for the purposes of our analysis we examined only the behaviors of hanging vertically, hanging cuddled (upside down), jumping, walking, and rearing up and down.…”

Section: Methodsmentioning

confidence: 99%

Daily Scheduled High Fat Meals Moderately Entrain Behavioral Anticipatory Activity, Body Temperature, and Hypothalamic c-Fos Activation

et al. 2012

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When fed in restricted amounts, rodents show robust activity in the hours preceding expected meal delivery. This process, termed food anticipatory activity (FAA), is independent of the light-entrained clock, the suprachiasmatic nucleus, yet beyond this basic observation there is little agreement on the neuronal underpinnings of FAA. One complication in studying FAA using a calorie restriction model is that much of the brain is activated in response to this strong hunger signal. Thus, daily timed access to palatable meals in the presence of continuous access to standard chow has been employed as a model to study FAA in rats. In order to exploit the extensive genetic resources available in the murine system we extended this model to mice, which will anticipate rodent high fat diet but not chocolate or other sweet daily meals (Hsu, Patton, Mistlberger, and Steele; 2010, PLoS ONE e12903). In this study we test additional fatty meals, including peanut butter and cheese, both of which induced modest FAA. Measurement of core body temperature revealed a moderate preprandial increase in temperature in mice fed high fat diet but entrainment due to handling complicated interpretation of these results. Finally, we examined activation patterns of neurons by immunostaining for the immediate early gene c-Fos and observed a modest amount of entrainment of gene expression in the hypothalamus of mice fed a daily fatty palatable meal.

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Striatal pathology underlies prion infection-mediated hyperactivity in mice

Abstract: (2010) Striatal pathology underlies prion infectionmediated hyperactivity in mice, Prion,4:4,[302][303][304][305][306][307][308][309][310][311][312][313][314][315]

Cited by 7 publications

References 60 publications

Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

Food Anticipatory Activity Behavior of Mice across a Wide Range of Circadian and Non-Circadian Intervals

Daily Scheduled High Fat Meals Moderately Entrain Behavioral Anticipatory Activity, Body Temperature, and Hypothalamic c-Fos Activation

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