Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

Murray, Rachael Z.; Logan, Mary C.; Horner, Kristen A.

doi:10.1016/j.brainres.2015.06.012

Cited by 21 publications

(20 citation statements)

References 62 publications

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“…These findings are also consistent with studies suggesting lesions of patches impair inflexible motor stereotypies 379 [31,32]. Jenrette et al noted deficits in press rates when sucrose rewards were paired with lithium chloride to 380 devalue sucrose rewards through taste aversion.…”

supporting

confidence: 82%

“…After repeated exposure, stimulant drugs of abuse drive expression of immediate early genes such as c-61 fos selectively in patches, and this expression is predictive of motor stereotypies [21,29,30]. Similarly, lesions of 62 striatal patches reduce stimulant-induced motor stereotypies [31,32], suggesting patches may subserve compulsive 63 behaviors. Recent work has found that pharmacological ablation of µ-opioid containing neurons, which are enriched 64 in patches, disrupts habitual responding for sucrose rewards in rats [33].…”

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confidence: 99%

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Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability

Nadel

Neidhart

Pawelko

et al. 2019

Preprint

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14Habits are automated behaviors that are insensitive to changes in behavioral outcomes. Habitual responding is 15 thought to be mediated by striatum, with medial striatum guiding goal-directed action and lateral striatum promoting 16 habits. However, interspersed throughout the striatum are neurochemically differing subcompartments known as 17 patches, which are characterized by distinct molecular profiles relative to the surrounding matrix tissue. These 18 structures have been thoroughly characterized neurochemically and anatomically, but little is known regarding their 19 function. Patches have been shown to be selectively activated during inflexible motor stereotypies elicited by 20 stimulants, suggesting that patches may subserve habitual behaviors. To explore this possibility, we utilized 21 transgenic mice (Sepw1 NP67) expressing Cre recombinase in striatal patches to target these neurons for selective 22 ablation with a virus driving Cre-dependent expression of caspase 3. Mice were then trained to press a lever for 23 sucrose rewards on a variable interval schedule to elicit habitual responding. Mice were not impaired on the 24 acquisition of this task, but lesioning striatal patches disrupted behavioral stability across training and lesioned mice 25 utilized a more goal-directed behavioral strategy during training. Similarly, when mice were forced to omit 26 responses to receive sucrose rewards, habitual responding was impaired in lesioned mice. To rule out effects of 27 lesion on motor behaviors, mice were then tested for impairments in motor learning on a rotarod and locomotion in October 15, 2019 2/22 28 an open field. We found that patch lesions specifically impaired initial performance on the rotarod without 29 modifying locomotor behaviors in open field. This work indicates that patches promote behavioral stability and 30 habitual responding, adding to a growing literature implicating striatal patches in stimulus-response behaviors. 31 32 33

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supporting

confidence: 82%

mentioning

confidence: 99%

Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability

Nadel

Neidhart

Pawelko

et al. 2019

Preprint

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“…Image J was used to outline regions of either dense µ opioid receptor immunoreactivity (patch) or absent µ opioid receptor immunoreactivity (matrix), which were superimposed over the corresponding areas of the adjacent c-Fos-labeled striatal section (Murray et al, 2014; Murray et al, 2015). The number c-Fos-labeled particles that exceeded the threshold density in each region of interest was determined using the particle analysis option in Image J.…”

Section: Methodsmentioning

confidence: 99%

Blockade of patch-based μ opioid receptors in the striatum attenuates methamphetamine-induced conditioned place preference and reduces activation of the patch compartment

Horner

Logan

Fisher

et al. 2017

European Journal of Pharmacology

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The behavioral effects of methamphetamine (METH) are mediated by the striatum, which is divided into the patch compartment, which mediates limbic and reward functions, and the matrix compartment, which mediates sensorimotor tasks. METH treatment results in repetitive behavior that is related to enhanced relative activation of the patch versus the matrix compartment. The patch, but not the matrix compartment contains a high density of µ opioid receptors, and localized blockade of patch-based µ opioid receptors attenuates METH-induced patch-enhanced activity and repetitive behaviors. Numerous studies have examined patch-enhanced activity and the contribution of patch-associated µ opioid receptors to METH-induced repetitive behavior, but it is not known whether patch-enhanced activity occurs during METH-mediated reward, nor is it known if patch-based µ opioid receptors contribute to METH reward. The goals of this study were to determine if blockade of patch-based µ opioid receptors alters METH-induced conditioned place preference (CPP), as well activation of the patch and matrix compartments following METH-mediated CPP. A biased conditioning paradigm was used to assess CPP, and conditioning occurred over an 8-day period. Animals were bilaterally infused in the striatum with the µ-specific antagonist CTAP or vehicle prior to conditioning. Animals were tested for preference 24h after the last day of conditioning, sacrificed and the brains processed for immunohistochemistry. Blockade of patch-based µ opioid receptors reduced METH-induced CPP, and reduced patch-enhanced c-Fos expression in the striatum following METH-mediated CPP. These data indicate that patch-enhanced activity is associated with METH-mediated reward and patch-based µ opioid receptors contribute to this phenomenon.

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“…All the stereotypy measures selected implicate striatal structures (Graybiel and Rauch 2000;Gillan et al 2011;Murray et al 2015) and the glutamatergic system (Horder et al 2013) burrowing and marble burying (Hashemi et al 2007;Welch et al 2007), leaning (Jousselin-Hosaja et al 2003), jumping (Presti et al 2004) stereotypical head dipping in mice (Irie et al 2012) and self-grooming (Yu et al 2018), but several groups have however questioned the uniqueness of the stereotypy concept (Bodfish et al 2000;Eilam et al 2006;Meiselas et al 1989;Muthugovindan and Singer 2009;Peter et al 2017).…”

Section: Matching In Mice Behavioral Measures With Clinical Featuresmentioning

confidence: 99%

Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice

et al. 2019

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Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from .68 to .81. The factor analysis resulted in a three-factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. The empirical validation with mice sharing a haplo-insufficiency of the zinc-finger transcription factor TSHZ3/Tshz3 associated with ASD shows the discriminant power of the highly loaded items. Mahrt E, AgarwalA, Perkel D, Portfors C, Elemans CP (2016) Mice produce ultrasonic vocalizations by intra-laryngeal planar impinging jets. Current biology : CB 26(19):R880-R881 Makanjuola RO, Hill G, Dow RC, Campbell G, Ashcroft GW (1977) The effects of psychotropic drugs on exploratory and stereotyped behaviour of rats studied on a hole-board. Psychopharmacology 55(1):67-74 Mandy WP, Skuse DH (2008) Research review: What is the association between the socialcommunication element of autism and repetitive interests, behaviours and activities? Journal of child psychology and psychiatry, and allied disciplines 49(8):795-808 Maxson SC, Canastar A (2003) Conceptual and methodological issues in the genetics of mouse agonistic behavior. Hormones and behavior 44(3):258-262 McDougle CJ, Kresch LE, Goodman WK, Naylor ST, Volkmar FR, Cohen DJ, Price LH (1995) A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. The American journal of psychiatry 152(5):772-777 Meiselas KD, Spencer EK, Oberfield R, Peselow ED, Angrist B, Campbell M (1989) Differentiation of stereotypies from neuroleptic-related dyskinesias in autistic children. Journal of clinical psychopharmacology 9(3):207-209

show abstract

Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration

Cited by 21 publications

References 62 publications

Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability

Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability

Blockade of patch-based μ opioid receptors in the striatum attenuates methamphetamine-induced conditioned place preference and reduces activation of the patch compartment

Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice

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