Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia
Taku Matsuda,
Ryoma Morigaki,
Hiroaki Hayasawa
et al.
Abstract:Dystonia is supposed to arise from abnormalities in the motor loop of the basal ganglia; however, there is an ongoing debate regarding cerebellar involvement. We adopted the established cerebellar dystonia mice model by injecting ouabain to examine the contribution of the cerebellum. Initially, we examined whether the entopeduncular nucleus (EPN), substantia nigra pars reticulata (SNr), globus pallidus externus (GPe), and striatal neurons were activated in the model. Next, we examined whether dopamine D1 recep… Show more
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