Striatal-insula circuits in cocaine addiction: implications for impulsivity and relapse risk

McHugh, Meredith J.; Demers, Catherine H.; Braud, J; Briggs, Richard W.; Adinoff, Bryon; Stein, Elliot A.

doi:10.3109/00952990.2013.847446

Cited by 101 publications

(92 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, cocaine-dependent subjects who relapse within 30 days of treatment display reduced connectivity between amygdala subregions and ventromedial and rostral anterior cingulate cortices (McHugh et al, 2014). It is important to note that altered functional connectivity in cocaine users may depend on the duration of abstinence before relapse (Camchong et al, 2011;McHugh et al, 2013) and is associated with cognitive deficits (Motzkin et al, 2014). Similar, and perhaps even greater, effects might occur following chronic use of MDPV.…”

Section: Discussionmentioning

confidence: 99%

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity

Colon-Perez

Tran

Thompson

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

The abuse of 'bath salts' has raised concerns because of their adverse effects, which include delirium, violent behavior, and suicide ideation in severe cases. The bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) has been closely linked to these and other adverse effects. The abnormal behavioral pattern produced by acute high-dose MDPV intake suggests possible disruptions of neural communication between brain regions. Therefore, we determined if MDPV exerts disruptive effects on brain functional connectivity, particularly in areas of the prefrontal cortex. Male rats were imaged following administration of a single dose of MDPV (0.3, 1.0, or 3.0 mg/kg) or saline. Resting state brain blood oxygenation level-dependent (BOLD) images were acquired at 4.7 T. To determine the role of dopamine transmission in MDPV-induced changes in functional connectivity, a group of rats received the dopamine D 1 /D 2 receptor antagonist cis-flupenthixol (0.5 mg/kg) 30 min before MDPV. MDPV dose-dependently reduced functional connectivity. Detailed analysis of its effects revealed that connectivity between frontal cortical and striatal areas was reduced. This included connectivity between the prelimbic prefrontal cortex and other areas of the frontal cortex and the insular cortex with hypothalamic, ventral, and dorsal striatal areas. Although the reduced connectivity appeared widespread, connectivity between these regions and somatosensory cortex was not as severely affected. Dopamine receptor blockade did not prevent the MDPV-induced decrease in functional connectivity. The results provide a novel signature of MDPV's in vivo mechanism of action. Reduced brain functional connectivity has been reported in patients suffering from psychosis and has been linked to cognitive dysfunction, audiovisual hallucinations, and negative affective states akin to those reported for MDPV-induced intoxication. The present results suggest that disruption of functional connectivity networks involving frontal cortical and striatal regions could contribute to the adverse effects of MDPV.

show abstract

Section: Discussionmentioning

confidence: 99%

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity

Colon-Perez

Tran

Thompson

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Further, the inter-network connectivity involving the insula has been reported to be weaker in cocaine users and related to their impulsivity [16] . The insular-striatal connection also mediates the association between impulsivity and cocaine relapse [17] . Moreover, inter-hemispheric insular FC is associated with addictive disorder [18] .…”

Section: The Insula and Addictionmentioning

confidence: 99%

“…As the loss of control in online gaming is one essential criterion of IGD [4] , high impulsivity could make subjects yield to the rewarding effect of gaming and contribute to the vulnerability of IGD. Further, the impulsivity has been reported to correlate with FC of the insula and nucleus accumbens [17,23] , particularly to the frontal lobe [15] . Thus, we hypothesized that impulsivity may influence the vulnerability of IGD by impacting its neurobiological underpinnings in FC of the insula and nucleus accumbens.…”

Section: Impulsivity and Addictionmentioning

confidence: 99%

“…According to previous studies, we hypothesized that the FC of the insula over the prefrontal lobe and contralateral insula and that of the nucleus accumbens over the prefrontal lobe and insula were altered among adults with IGD. Further, FCs of these brain regions play essential roles in impulsivity [17,23] , which is one possible mechanism of IGD. Thus, we evaluated the correlation between the FCs of the insula and nucleus accumbens and impulsivity in this study.…”

Section: Impulsivity and Addictionmentioning

confidence: 99%

See 1 more Smart Citation

Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study

Chen¹,

Yen

Wang

et al. 2016

Eur Addict Res

View full text Add to dashboard Cite

Aims: A possible addiction mechanism has been represented by altered functional connectivity (FC) in the resting state. The aim of this study was to evaluate the FCs of the insula and nucleus accumbens among subjects with Internet gaming disorder (IGD). Methods: We recruited 30 males with IGD and 30 controls and evaluated their FC using functional magnetic imaging scanning under resting, a state with relaxation, closed eyes, with inducement to think of nothing systematically, become motionless, and instructed not to fall asleep. Results: Subjects with IGD had a lower FC with the left insula over the left dorsolateral prefrontal cortex (DLPFC) and orbital frontal lobe and a higher FC with the insula with the contralateral insula than controls. The inter-hemispheric insula connectivity positively correlated with impulsivity. Further, they had lower FC with the left nucleus accumbens over the left DLPFC and with the right nucleus accumbens over the left DLPFC, and insula and a higher FC with that over the right precuneus. Conclusion: The elevated inter-hemispheric insula FC is found to be associated with impulsivity and might explain why it is involved in IGD. The attenuated frontostriatal suggests that the emotion-driven gaming urge through nucleus accumbens could not be well regulated by the frontal lobe of subjects with IGD.

show abstract

“…Moreover, voxelbased morophometry (VBM) studies have shown smaller volumes of the striatum, prefrontal cortex, temporal cortex and insula, in cocaine users compared to controls (Ersche et al, 2011;Franklin et al, 2002;Moreno-López et al, 2012;Weller et al, 2011). These regions, in particular the circuit including the insula and the prefrontal cortex, play an important role in the control over impulsive behaviour in addiction (Bari and Robbins, 2013;Jentsch and Taylor, 1999;McHugh et al, 2013;Noël et al, 2013). Unfortunately, only few VBM studies directly investigated the relation between cortical morphometry and trait impulsivity in cocaine users and controls.…”

Section: Introductionmentioning

confidence: 99%

Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls

Kaag

Crunelle

Wingen

et al. 2014

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

Striatal-insula circuits in cocaine addiction: implications for impulsivity and relapse risk

Cited by 101 publications

References 68 publications

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity

Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study

Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls

Contact Info

Product

Resources

About