Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

David, Renaud; Koulibaly, Malick; Benoît, Michel; García, René; Caci, Hervé; Darcourt, Jacques; Robert, Philippe

doi:10.1016/j.clineuro.2007.08.007

Cited by 99 publications

(67 citation statements)

References 35 publications

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“…not explained by a low frequency or narrow range of apathy scores, but the possibility of a type II error cannot be ruled out. Our findings are somewhat at odds with recently published data in a mixed sample of patients with AD and Lewy body dementia, 8 and there are several possible explanations for this. It is possible that previous findings reflect primarily an association between apathy and striatal DA transporter function in patients with Lewy body dementia, or-assuming that the association is representative of the AD population-that presynaptic neuronal integrity is a more sensitive indicator of apathy than postsynaptic receptor sites.…”

Section: Results Descriptive and Neuropsychological Testcontrasting

confidence: 57%

“…7 More recently, higher striatal DA transporter availability has been correlated with apathy ("loss of initiative") in a larger sample (n ϭ 24) that included 8 patients with Lewy body dementia. 8 We aimed to test the hypothesis that striatal DA (D2) receptor availability-using the DA (D2/D3) receptor ligand [ 11 C]raclopride (RAC)-would be associated with delusions and apathy in psychotropic-naive patients with mild to moderate AD.…”

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confidence: 99%

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Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Reeves¹,

Brown²,

Howard³

et al. 2009

Neurology

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Objective: Dysfunction within corticostriatal dopaminergic neurocircuitry has been implicated in neuropsychiatric symptoms associated with Alzheimer disease (AD). This study aimed to test the hypothesis that the symptom domains delusions and apathy would be associated with striatal dopamine (D2) receptor function in AD. Methods:In vivo dopamine (D2/D3) receptor availability was determined with [ 11 C]raclopride (RAC) PET in 23 patients with mild and moderate probable AD. Behavioral symptoms were measured using the Neuropsychiatric Inventory and the Apathy Inventory. Imaging data were analyzed using a region-of-interest approach. The potential confounding effects of age, sex, and disease stage were explored using a linear mixed model. Correlational and independent samples comparisons were used to examine the relationship between behavioral and binding potential (BP ND ) measures. Results: Mean [11 C]RAC BP ND was higher in patients with delusions (n ϭ 7; 5 men) than in patients without delusions (n ϭ 16; 6 men) (p ϭ 0.006). When women were excluded from the analysis,

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Section: Results Descriptive and Neuropsychological Testcontrasting

confidence: 57%

mentioning

confidence: 99%

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Reeves¹,

Brown²,

Howard³

et al. 2009

Neurology

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“…In particular, in a phase III multicentre study among a large cohort of subjects, McKeith and co-workers determined the effectiveness of FP-CIT SPECT to distinguish DLB from other dementias (principally AD), revealing a sensitivity and specificity of respectively 78% and 90% respectively. So far, there have been published many studies that investigated DLB by dopaminergic SPECT (Colloby et al, 2005;David et al, 2008;Lim et al, 2009;O'brien et al, 2009;Roselli et al, 2009;Walker et al, 2007). All these works consistently show the diagnostic value of dopaminergic SPECT as applied to DLB, through the evaluation of the striatal dopaminergic innervations reduction, also in the distinction from other dementias (Soret et al, 2006).…”

Section: Single Photon Emission Computed Tomography (Spect)mentioning

confidence: 95%

“…Moreover, Roselli et al (Roselli et al, 2009) found significant correlations between decreased striatal DAT levels and visual hallucinations in DLB patients. The association of behavioural disturbances and SPECT analysis was also investigated (David et al, 2008), in order to assess the relationship between apathy and DAT uptake in DLB and AD patients: a significant correlation was found between lack of initiative and bilateral putamen DAT uptake, demonstrating a relationship between apathy and DAT levels. Perfusion SPECT studies, instead, use markers such as 99 mTc-hexamethylpropyleneamine oxime to identify deficits in the functional pattern of brain activity.…”

Section: Single Photon Emission Computed Tomography (Spect)mentioning

confidence: 99%

Neuroimaging Findings in Dementia with Lewy Body: A Review

Baglio¹,

Preti²,

Farina³

2012

Neuroimaging - Methods

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“…Compensation for partial-volume effects will likely require anatomic images that clearly delineate the tumor (35)(36)(37)(38). Volumetric MRI with contrast may prove to be ideal for this, but unfortunately, all of the MR images cited in this work were obtained before the patient entered the study.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Assay of Folate Receptors in Nonfunctional Pituitary Adenomas with ^99mTc-Folate SPECT/CT

et al. 2010

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The objective of this study was to evaluate the in vivo assay of folate receptors in nonfunctional pituitary adenomas using preoperative 99m Tc-folate SPECT/CT and Western blot analysis (WBA) of surgical specimens as the standard. Methods: Fifty-six patients (29 men, 27 women; age range, 29-82 y) with clinically nonfunctional pituitary adenomas on MRI underwent preoperative imaging using 666 MBq (18 mCi) of 99m Tc-folate. SPECT/CT images and whole-body and lateral head planar images were acquired approximately 2 h after injection. Surgical resection took place within a week. WBA on a portion of the excised specimens assessed folate receptor expression in 49 patients. Attenuation-corrected 99m Tcfolate SPECT/CT images were assessed qualitatively and quantitatively (maximal adenoma counts to background), with WBA as a standard. Results: Integrated CT was useful for uptake localization and assisted region-of-interest placement. Qualitative interpretation of planar imaging yielded a sensitivity of 81% and specificity of 72%. Qualitative SPECT/CT yielded a sensitivity of 94% and specificity of 61%. Receiver-operating-characteristic curve analysis of quantitative uptake yielded a tumor-to-background cutoff ratio of 3.5, with a sensitivity of 81% and specificity of 83%. Scalp uptake yielded consistent results (over the brain, neck, and choroid plexus) for background when SPECT/CT misalignment artifacts were avoided. Detection of pituitary uptake on anterior-posterior and lateral images was hampered by facial uptake, which varied between patients. Conclusion: SPECT/CT of 99m Tc-folate is an accurate method of assaying folate receptors in vivo and may provide a quantitative marker for identifying folate receptor-positive tumors. This method may also prove beneficial in selecting patients for folate-targeted therapy of clinically nonfunctional pituitary adenomas, for which there is currently no medical therapy.

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

Cited by 99 publications

References 35 publications

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Neuroimaging Findings in Dementia with Lewy Body: A Review

In Vivo Assay of Folate Receptors in Nonfunctional Pituitary Adenomas with ^99mTc-Folate SPECT/CT

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

Cited by 99 publications

References 35 publications

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

Neuroimaging Findings in Dementia with Lewy Body: A Review

In Vivo Assay of Folate Receptors in Nonfunctional Pituitary Adenomas with 99mTc-Folate SPECT/CT

Contact Info

Product

Resources

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In Vivo Assay of Folate Receptors in Nonfunctional Pituitary Adenomas with ^99mTc-Folate SPECT/CT