Striatal dopamine transporter abnormalities in patients with essential tremor

Isaias, Ioannis U.; Canesi, Margherita; Benti, Riccardo; Gerundini, Paolo; Cilia, Roberto; Pezzoli, Gianni; Antonini, Angelo

doi:10.1097/mnm.0b013e3282f4d307

Cited by 75 publications

(57 citation statements)

References 24 publications

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“…Moreover, two studies reported a mild reduction in striatal dopamine transporter binding in 60 ‘pure’ essential tremor patients compared to 59 healthy controls although less severe compared to 80 Parkinson's disease patients (Gerasimou et al, 2012; Isaias et al, 2008). The reduced dopaminergic uptake pattern differed between the studies.…”

Section: Resultsmentioning

confidence: 99%

Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

126

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BackgroundEssential tremor is regarded to be a disease of the central nervous system. Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and research. The exact role of imaging techniques with respect to essential tremor in research and clinical practice is not clear. A systematic review of the different imaging techniques in essential tremor is lacking in the literature.MethodsWe performed a systematic literature search combining the terms essential tremor and familial tremor with the following keywords: imaging, MRI, VBM, DWI, fMRI, PET and SPECT, both in abbreviated form as well as in full form. We summarize and discuss the quality and the external validity of each study and place the results in the context of existing knowledge regarding the pathophysiology of essential tremor.ResultsA total of 48 neuroimaging studies met our search criteria, roughly divided into 19 structural and 29 functional and metabolic studies. The quality of the studies varied, especially concerning inclusion criteria. Functional imaging studies indicated cerebellar hyperactivity during rest and during tremor. The studies also pointed to the involvement of the thalamus, the inferior olive and the red nucleus. Structural studies showed less consistent results.Discussion and conclusionNeuroimaging techniques in essential tremor give insight into the pathophysiology of essential tremor indicating the involvement of the cerebellum as the most consistent finding. GABAergic dysfunction might be a major premise in the pathophysiological hypotheses. Inconsistencies between studies can be partly explained by the inclusion of heterogeneous patient groups. Improvement of scientific research requires more stringent inclusion criteria and application of advanced analysis techniques. Also, the use of multimodal neuroimaging techniques is a promising development in movement disorders research. Currently, the role of imaging techniques in essential tremor in daily clinical practice is limited.

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Section: Resultsmentioning

confidence: 99%

Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

126

View full text Add to dashboard Cite

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“…Similarly, the standardized uptake value ratio (SUVR FDG ) was calculated for each subject as the ratio of mean count per voxel of basal ganglia VOIs to mean count per voxel of the global 18 F‐FDG brain uptake. Additionally, for 123 I‐FP‐CIT the asymmetry index (AI) and the putamen‐caudate ratio (PCIDX)18 were also calculated.…”

Section: Methodsmentioning

confidence: 99%

Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study

Brumberg

Küsters

Al‐Momani

et al. 2017

Ann Clin Transl Neurol

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ObjectiveTo investigate the association between levodopa‐induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease.MethodsThis study included 13 Parkinson's disease patients with peak‐of‐dose levodopa‐induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5‐[123I]iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine single‐photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [123I]N‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane single‐photon emission computed tomography, to measure dopamine reuptake transporter density and 2‐[18F]fluoro‐2‐deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed.ResultsDensity of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side.InterpretationOur findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic‐depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression.

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“…Several studies have shown that patients with PD were more likely to have ET while patients with ET were four times more likely than controls to develop PD (Tan et al 2008;Benito-León et al 2009). Dopaminergic deficiency and brainstem Lewy bodies (LB) have been demonstrated in both ET and PD (Isaias et al 2008). Patients with familial-linked PD genes (such as LRRK2) can present with ET (Skipper et al 2005), and alpha synuclein promoter polymorphism has been associated with both ET and PD (Tan et al 2000).…”

Section: Introductionmentioning

confidence: 98%

Lingo2 variants associated with essential tremor and Parkinson’s disease

Prakash

Rong

et al. 2011

Hum Genet

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LINGO2, a member of LRR gene family, has been linked with both Essential tremor (ET) and Parkinson's disease (PD). However, there is a lack of conclusive evidence regarding the etiologic role of LINGO2 genetic variants. We investigated the association of LINGO2 variants with ET and PD in two independent Asian countries. A total of 1,262 subjects comprising 499 controls, 436 PD patients, and 327 ET patients were included. Eight LINGO2 variants, including four single-nucleotide polymorphisms (SNPs) and four coding variants, were initially analyzed in one Asian population. SNPs that showed positive association were then replicated in the second independent Asian population, and a pooled analysis was carried out. Out of the eight variants, two SNPs (rs7033345 and rs10812774) revealed significant or strong positive trend in the first Asian population, and these were analyzed in the second Asian population. In the pooled analysis, the CC genotype at rs7033345 had a higher risk of developing PD (OR = 1.67, 95% CI = 1.18, 2.35, p = 0.003) and ET (OR = 1.50, 95% CI = 1.02, 2.20, p = 0.04) under a recessive model. The C allele at rs10812774 increased the risk of ET (OR = 1.56 95% CI = 1.10, 2.22, p = 0.01) via a recessive model. The effect size and direction of trend were in the same direction in each of the two populations. Our study demonstrated for the first time that rs7033345 is associated with PD and ET and rs10812774 with ET among Asians, suggesting that LINGO2 might act as a susceptibility gene for both conditions.

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Striatal dopamine transporter abnormalities in patients with essential tremor

Abstract: Our results show that some essential tremor patients may present mild abnormalities of striatal dopamine transporters and a typical Parkinson's disease-like pattern of uptake loss. These findings suggest a link between the two disorders.

Cited by 75 publications

References 24 publications

Neuroimaging essentials in essential tremor: A systematic review

Neuroimaging essentials in essential tremor: A systematic review

Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study

Lingo2 variants associated with essential tremor and Parkinson’s disease

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