Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study

Pogarell, Oliver; Koch, Walter; Pöpperl, Gabriele; Tatsch, Klaus; Jakob, Franziska; Zwanzger, Peter; Mulert, Christoph; Rupprecht, Rainer; Möller, Hans‐Jürgen; Hegerl, Ulrich; Padberg, Frank

doi:10.1016/j.jpsychires.2005.09.001

Cited by 157 publications

(108 citation statements)

References 59 publications

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“…Moreover, prefrontal rTMS has been found to influence striatal dopaminergic activity [57,58]. It should not be excluded that this represents at least one of the leading mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

Low-Frequency rTMS over Right Dorsolateral Prefrontal Cortex in the Treatment of Resistant Depression: Cognitive Improvement Is Independent from Clinical Response, Resting Motor Threshold Is Related to Clinical Response

et al. 2012

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Background: Clinical studies have shown that repetitive transcranial magnetic stimulation (rTMS) is effective in a certain percentage of treatment-resistant depression (TRD). The left dorsolateral prefrontal cortex (DLPFC) 10 Hz rTMS stimulation received FDA approval in 2008, although different rTMS protocols have also shown their effectiveness in reducing depressive symptoms. We investigated the clinical, cognitive and neurophysiologic effects of a 3 weeks’ protocol of low-frequency rTMS applied over the right DLPFC in resistant depression. Methods: Twenty-eight patients with TRD (age range 28–55) received low-frequency rTMS (1 Hz) over the right DLPFC in a 3-week open trial. Hamilton scales for depression and anxiety, Corsi block-tapping test, phonemic verbal fluency, right and left resting motor thresholds were evaluated in each subject over the trial period. Results: At the end of the trial 42.9% of the subjects were considered as responders. A significant reduction of both HAMD (p < 0.001) and HAMA (p < 0.01) total scores was observed. At the 3rd week, the performances in Corsi test (p < 0.02) and phonemic verbal fluency (p = 0.065) were improved independently from depressive symptoms variation. At the end of the rTMS protocol, a significantly decreased left hemisphere resting motor threshold was registered (p < 0.01), while right hemisphere resting motor threshold did not show significant variation. Conclusion: Low-frequency rTMS over the right DLPFC appeared effective in 42.9% of depressive resistant subjects in this sample. A significant decrease in left hemisphere resting motor threshold was observed only in responders, while a trend for improvement in cognitive function has been found and appeared independent from clinical response.

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Section: Discussionmentioning

confidence: 99%

Low-Frequency rTMS over Right Dorsolateral Prefrontal Cortex in the Treatment of Resistant Depression: Cognitive Improvement Is Independent from Clinical Response, Resting Motor Threshold Is Related to Clinical Response

et al. 2012

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“…On a neurobiological standpoint of view, it has been hypothesized that a possible working mechanism of action of this kind of treatment could be on the dopaminergic system as several studies point to an rTMS-related release in endogenous dopamine when stimulating prefrontal cortical areas (Strafella et al, 2001;Pogarell et al, 2006Pogarell et al, , 2007. Without coconcomitant brain imaging techniques is speculative to assume that our clinical HF-rTMS effects on psychomotor improvement are associated with a 'hypodopaminergic state'.…”

Section: Discussionmentioning

confidence: 99%

“…However, besides effects on the dopaminergic system (e.g. Pogarell et al, 2006), it has been demonstrated that HF-rTMS increases serotonin concentrations as well (e.g. Ben-Shachar et al, 1999 Graphical representation of the two-way ANOVA data with psychomotor symptoms (DDRS before and after treatment) as within subjects factor and treatment response (responder vs. nonresponder) as between-subjects factor.…”

Section: Discussionmentioning

confidence: 99%

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

Baeken¹,

Raedt²,

Santermans³

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Although it is unclear how rTMS exerts its effects on smoking, it has been suggested that rTMS increases the availability of striatal dopamine ( Pogarell et al, 2006;Strafella et al, 2001), which may reduce the level of craving (de la Fuente-Fernandez et al, 2002;Ernst, 2007;Perkins et al, 2003). Withdrawal symptoms may even be improved with transient increases in dopamine secretion (Amiaz et al, 2009).…”

Section: Treatment Of Nicotine Addiction With Rtmsmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation and drug addiction

Barr

Farzan

Wing

et al. 2011

International Review of Psychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that is now being tested for its ability to treat addiction. This review discusses current research approaches and results of studies which measured the therapeutic use of rTMS to treat tobacco, alcohol and illicit drug addiction. The research in this area is limited and therefore all studies evaluating the therapeutic use of rTMS in tobacco, alcohol or illicit drug addiction were retained including case studies through NCBI PubMed (http://www.ncbi.nlm.nih.gov) and manual searches. A total of eight studies were identifi ed that examined the ability of rTMS to treat tobacco, alcohol and cocaine addiction. The results of this review indicate that rTMS is effective in reducing the level of cravings for smoking, alcohol, and cocaine when applied at high frequencies to the dorsolateral prefrontal cortex (DLPFC). Furthermore, these studies suggest that repeated sessions of high frequency rTMS over the DLPFC may be most effective in reducing the level of smoking and alcohol consumption. Although work in this area is limited, this review indicates that rTMS is a promising modality for treating drug addiction.

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Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: Preliminary results of a dynamic [123I] IBZM SPECT study

Cited by 157 publications

References 59 publications

Low-Frequency rTMS over Right Dorsolateral Prefrontal Cortex in the Treatment of Resistant Depression: Cognitive Improvement Is Independent from Clinical Response, Resting Motor Threshold Is Related to Clinical Response

Low-Frequency rTMS over Right Dorsolateral Prefrontal Cortex in the Treatment of Resistant Depression: Cognitive Improvement Is Independent from Clinical Response, Resting Motor Threshold Is Related to Clinical Response

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

Repetitive transcranial magnetic stimulation and drug addiction

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