Striatal dopamine distribution in Parkinsonian patients during life

Nahmias, Claude; Garnett, E. S.; Firnau, G.; Lang, Anthony E.

doi:10.1016/0022-510x(85)90135-2

Cited by 179 publications

(53 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the forebrain, the main signs are striatal DA loss and degeneration of the striatum itself (Spokes et al, 1979;Oppenheimer, 1983). Some studies employing neuro-imaging have demonstrated a relatively lower caudate uptake of [ l8 F]fluoro-dopa in MSA patients, in contrast to the relatively preserved uptake in this region in PD (Nahmias et al, 1985;Rutledge et al, 1987;Brooks et al, 1990a,Z? ).…”

Section: Discussionmentioning

confidence: 99%

Cognitive Performance in Multiple System Atrophy

Robbins

James

Lange³

et al. 1992

Brain

150

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Cognitive Performance in Multiple System Atrophy

Robbins

James

Lange³

et al. 1992

Brain

150

View full text Add to dashboard Cite

“…This may account for the increased variability found in the putaminal measures, which prevented statistically significant results. In PD, unlike MPTP-treatment, the putamen is substantially more affected than the caudate nucleus (17,18,24,28). Because of this, the influence of implanted hNSC on the putamen, might be more apparent in PD, resembling the "normalizing" effects that hNSC have in the caudate nucleus after MPTP treatment.…”

Section: Introducutionmentioning

confidence: 99%

Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures

et al. 2005

View full text Add to dashboard Cite

Neural stem cells (NSC) have been shown to migrate towards damaged areas, produce trophic factors, and replace lost cells in ways that might be therapeutic for Parkinson's disease (PD). However, there is very little information on the effects of NSC on endogenous cell populations. In the current study, effects of implanted human NSC (hNSC) on endogenous tyrosine hydroxylase-positive cells (TH+ cells) after treatment with 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) were explored in nonhuman primates. After MPTP damage and in PD, the primate brain is characterized by decreased numbers of dopamine neurons in the substantia nigra (SN) and an increase in neurons expressing TH in the caudate nucleus. To determine how implanted NSC might affect these cell populations, 11 St. Kitts African green monkeys were treated with the selective dopaminergic neurotoxin, MPTP. Human NSC were implanted into the left and right caudate nucleus and the right SN of eight of the MPTP-treated monkeys. At either 4 or 7 months after NSC implants, the brains were removed and the size and number of TH+ cells in the target areas were assessed. The results were compared to data obtained from normal untreated control monkeys and to the three unimplanted MPTP-treated monkeys. The majority of hNSC were found bilaterally along the nigrostriatal pathway and in the substantia nigra, while relatively few were found in the caudate. In the presence of NSC, the number and size of caudate TH+ cells returned to non-MPTP-treated control levels. MPTP-induced and hNSC-induced changes in the putamen were less apparent. We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment.

show abstract

“…The pure akinetic type has been considered to be a different clinical entity from idiopathic Parkinson's disease by some investigators. ' (1)(2)(3)(4)(5)(6)(7)(8) and patients with atypical Parkinsonism (PKM) (9- I I I II III III III III II III III II II III III Case 9 A 54 year old right handed man started to complain of writing difficulty at the age of 50. This was followed by dysarthria (microphonia).…”

Section: Introductionmentioning

confidence: 99%