Stria terminalis microstructure in humans predicts variability in orienting towards threat

Koller, Kristin; Hatton, Christopher M.; Rogers, Robert D.; Rafal, Robert D.

doi:10.1111/ejn.14504

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…To further interpret how these differences in ST microstructure may relate to functional outcomes, two recent studies provide insights. Koller et al showed that greater ST FA is associated with greater orienting bias toward threat in a saccadic decision task (Koller et al, 2019). Another study by Dzafic et al showed that greater ST microstructure was associated with faster recognition of anger following an anger cue during a dynamic emotional perception task (Dzafic et al, 2019).…”

Section: Functional Implications Of Deprivation-related Enhanced Stria Terminalis Structural Integrity: a Potential Neural Adaptation?mentioning

confidence: 99%

“…The ST has been carefully mapped in non-human primates using neuroanatomical and neuroimaging techniques (Oler et al, 2017). Several studies have examined and/or mapped the ST in humans (Avery et al, 2014;Dzafic, Oestreich, Martin, Mowry, & Burianová, 2019;Eluvathingal et al, 2006;Folloni et al, 2019;Kamali et al, 2015;Koller, Hatton, Rogers, & Rafal, 2019;Krüger, Shiozawa, Kreifelts, Scheffler, & Ethofer, 2015;Kwon, Byun, Ahn, Son, & Jang, 2011;Tromp et al, 2019) and Rafal et al have examined the ST in humans and non-human primates (Rafal et al, 2015). The majority of these human ST and MFB studies have used standard diffusion tensor imaging (DTI); thus, detailed tractography of the ST and MFB using high-resolution diffusion weighted imaging (DWI) (e.g., multi-shell DWI and/or diffusion spectrum imaging) in human brain is of interest.…”

Section: Introductionmentioning

confidence: 99%

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Opposing relationships of childhood threat and deprivation with stria terminalis white matter

Banihashemi

Peng

Verstynen

et al. 2021

Human Brain Mapping

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While stress may be a potential mechanism by which childhood threat and deprivation influence mental health, few studies have considered specific stress-related white matter pathways, such as the stria terminalis (ST) and medial forebrain bundle (MFB). Our goal was to examine the relationships between childhood adversity and ST and MFB structural integrity and whether these pathways may provide a link between childhood adversity and affective symptoms and disorders. Participants were young adults (n = 100) with a full distribution of maltreatment history and affective symptom severity. Threat was determined by measures of childhood abuse and repeated traumatic events. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education). Participants underwent diffusion spectrum imaging. Human Connectome Project data was used to perform ST and MFB tractography; these tracts were used as ROIs to extract generalized fractional anisotropy (gFA) from each participant. Childhood threat was associated with ST gFA, such that greater threat was associated with less ST gFA. SED was also associated with ST gFA, however, conversely to threat, greater SED was associated with greater ST gFA. Additionally, threat was negatively associated with MFB gFA, and MFB gFA was negatively associated with post-traumatic stress symptoms. Our results suggest that childhood threat and deprivation have opposing influences on ST structural integrity, providing new evidence that the context of childhood adversity may have an important influence on its neurobiological effects, even on the same structure. Further, the MFB may provide a novel link between childhood threat and affective symptoms.

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Section: Functional Implications Of Deprivation-related Enhanced Stria Terminalis Structural Integrity: a Potential Neural Adaptation?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Opposing relationships of childhood threat and deprivation with stria terminalis white matter

Banihashemi

Peng

Verstynen

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Although studies concerning the anger attentional bias in infancy show inconsistent results (LoBue & DeLoache, 2009; LoBue et al, 2017), our results support the idea that during school age, children learn to prioritize the detection of threats in the environment. Greater attention to angry faces has been observed in adults through behavioral (Calvo et al, 2006; Fox et al, 2001; Seidel et al, 2010) and neurofunctional studies (Koller, Hatton, et al, 2019; Koller, Rafal, et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of sex on the attentional orientation bias toward emotional expressions in children: An eye-tracking study.

Ramos-Loyo,

Padilla de Anda,

Matute

et al. 2023

Psychology & Neuroscience

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Objective: Emotional facial expressions attract attention automatically, but because some emotions provide information that is more important for social adaptation than others, it is plausible to suggest that differences in attentional orientation toward them may exist. The objective of this research was to study the attentional orientation toward facial expressions depending on: (a) the sex of the child; (b) the sex of the model; and (c) its relationship with children’s age. Method: A total of 64 children (6–12 years) participated. Eye movements were tracked while children observed pairs of facial expressions of happiness, sadness, and anger. Results: Findings showed a higher number of first fixations toward happiness and anger than sadness regardless of the sex of the children; a higher number of first fixations toward happiness than anger expressions in women’s faces, and the opposite in men’s faces. Furthermore, the age of the children successfully predicted: the increase in the number of first fixations toward sadness and its duration toward emotions expressed by women and; the decrease of the total observation time after the first fixation toward men’s emotions only in boys. Conclusions: Children’s attention is more automatically attracted to women’s happiness and men’s anger expressions. The time spent looking at women’s faces increases with age only in boys. On the contrary, boys develop attentional avoidance for men’s faces, particularly to anger, with increasing age. Since gaze is highly relevant in social interaction, the more direct-gaze attention to women’s faces may facilitate child/women compared to child/men relationships.

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“…Furthermore, the ST reconstructed in our proposed method was closer to the anatomical morphology than previous studies. Additionally, an increasing number of studies have found that the changes in the ST are correlated with decision‐making, dissociative seizures, alcohol use disorder, major depressive disorder and other functional neurological disorders (Diez et al, 2021; Flook et al, 2021; Jungilligens et al, 2021; Koller et al, 2019). However, all of these DTI based tractography studies are sensitive to the partial volume effects.…”

Section: Discussionmentioning

confidence: 99%

Tractography of the stria terminalis in the human brain

Zhang

et al. 2022

Clinical Anatomy

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The aim of this study was to investigate the trajectory of the stria terminalis and develop a protocol for mapping the stria terminalis using multi‐shell diffusion images based tractography. The stria terminalis was reconstructed by combining one region of interest at the amygdala with another region of interest at the bed nucleus of stria terminalis. In addition, one region of avoidance was placed on the fornix at the interventricular foramen and another was set at the anterior perforated substance. The fiber‐tracking protocol was tested in a Human Connectome Project‐842 template, 35 healthy subjects from Massachusetts General Hospital, and 20 healthy subjects from the Human Connectome Project using generalized q‐sampling imaging based tractography. The stria terminalis was reconstructed in the Human Connectome Project‐842 template, 35 Massachusetts General Hospital healthy subjects, and 20 Human Connectome Project healthy subjects with our protocol. The stria terminalis originated from the amygdala and traveled parallel to the fornix. Then, the stria terminalis followed a C‐shaped trajectory around the inferior, posterior, and dorsal surfaces of the thalamus before projecting to the bed nucleus of stria terminalis between the thalamus and caudate nucleus. There were no significant differences in the quantitative anisotropy and fractional anisotropy values between the left and right stria terminalis. The stria terminalis was accurately visualized across subjects using multi‐shell diffusion images through generalized q‐sampling imaging based tractography. This method could be an important tool for the reconstruction and evaluation of the stria terminalis in various neurological disorders. One Sentence Summary The visualization of the stria terminalis through the multi‐shell diffusion images using generalized q‐sampling imaging based tractography.

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Stria terminalis microstructure in humans predicts variability in orienting towards threat

Cited by 11 publications

References 25 publications

Opposing relationships of childhood threat and deprivation with stria terminalis white matter

Opposing relationships of childhood threat and deprivation with stria terminalis white matter

Effects of sex on the attentional orientation bias toward emotional expressions in children: An eye-tracking study.

Tractography of the stria terminalis in the human brain

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