Abstract. The pathway model of Mathai (2005) is shown to be inferable from the maximization of a certain generalized entropy measure. This entropy is a variant of the generalized entropy of order α, considered in Mathai and Rathie (1975), and it is also associated with Shannon, Boltzmann-Gibbs, Rényi, Tsallis, and Havrda-Charvát entropies. The generalized entropy measure introduced here is also shown to have interesting statistical properties and it can be given probabilistic interpretations in terms of inaccuracy measure, expected value, and information content in a scheme. Particular cases of the pathway model are shown to be Tsallis statistics (Tsallis, 1988) and superstatistics introduced by Beck and Cohen (2003). The pathway model's connection to fractional calculus is illustrated by considering a fractional reaction equation.