Stretchable Electronic Facial Masks for Sonophoresis

Abstract

We introduce a stretchable electronic facial mask (SEFM) as a platform for facial healthcare, which can integrate with various sensors and actuators. As a demonstration, an SEFM for sonophoresis enabling the promotion of the delivery effect of a drug mask is developed. To overcome the technique challenges, several approaches including the design of the joined silicone layer by two planar half-face portions and the single-side soft pressing (SSSP) technique for encapsulation are exploited in this work, which could be extended to the design and fabrication of other stretchable electronics. The mechanical, thermal, electrical, and ultrasonic characteristics of the SEFM are all verified by the finite element analysis and experiments. Finally, we prove the effect of the SEFM on accelerating the delivery of hyaluronic acid (HA) through animal experiments and confirm that the SEFM can enhance the skin moisture content by 20% via human facial experiments.

A Conformable Ultrasound Patch for Cavitation‐Enhanced Transdermal Cosmeceutical Delivery

“…Bulky and power‐consumptive equipment, [ 74 ] long exposure times, and high variability between the permeability enhancement observed in vivo and in vitro [ 32 ] have been cited as the main challenges to the successful deployment and adoption of transdermal drug delivery systems. Recently, wearable system concepts have been proposed that demonstrate good performance in vivo [ 48 ] using HFS but few studies have characterized the working physics of the enhancement mechanisms required to guarantee repeatability. In this study, we use a combined theoretical and experimental approach to characterize and precisely control the ultrasound transducer deflection, device geometry, resulting pressure field, and heat generation within the medium to induce cavitation in a repeatable manner using IFS.…”

Tracking tumor heterogeneity and progression with near‐infrared II fluorophores

“…Reproduced with permission. [ 65 ] Copyright 2015, American Chemical Society. (C) The energy transfer pathway of ICG‐sensitized CSS nanocrystals, NIR‐II emission spectra, and NIR‐II photoluminescent image.…”

“…Furthermore, a series of biomedical “visualization” studies have been developed successively at the NIR‐II fluorescence window. [ 38,65 ] In 2015, a specific protein nanocage (PNC) encapsulated by Ag 2 S QD was proposed by the group to observe PNCs behavior in vivo via using the monkey virus PNC SV40 model. [ 65 ] The dynamic distribution of PNC SV40 in vivo could be tracked with high fidelity due to the superiorities of deep‐tissue penetration, and high resolution of NIR‐II fluorescence.…”

“…[ 38,65 ] In 2015, a specific protein nanocage (PNC) encapsulated by Ag 2 S QD was proposed by the group to observe PNCs behavior in vivo via using the monkey virus PNC SV40 model. [ 65 ] The dynamic distribution of PNC SV40 in vivo could be tracked with high fidelity due to the superiorities of deep‐tissue penetration, and high resolution of NIR‐II fluorescence. Furthermore, the surface chemical‐dependent behavior of PNC SV40 was revealed by adopting the PEG strategy (Figure 3B).…”

A Precipitation‐Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR‐II Fluorophores

“…[ 3–6 ] Therefore, NIR‐II dyes have attracted increasing attention in the past decade. [ 7–12 ] Among them, organic fluorophores have broad clinical application prospects because of their known molecular structures, facile derivatization, and potentially minimal toxicity. [ 13–16 ]…”