Stretchable, conductive, breathable and moisture-sensitive e-skin based on CNTs/graphene/GelMA mat for wound monitoring

Li, Yingchun; Liu, Yannan; Peng, Bo; Li, Xinyue; Fang, Tianshu; Liu, Shuai; Liu, Jiachen; Li, Bo; Li, Fēi

doi:10.1016/j.bioadv.2022.213172

Cited by 12 publications

(9 citation statements)

References 62 publications

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“…It can plausibly be attributed to the adequate solubility of CUR–PYR that causes the produced ointment adheres easily to the wound bed and stays there for several hours. Reviewing previous literature shows that numerous advanced dressings have been suggested to help wound healing by providing balanced moisture to the wound site. ,,− Regarding the greater importance of re-epithelialization than contraction in human wound repair, on the other hand, several materials like foils, splints and human-mouse xenografts have been examined to avoid contraction during wound repair. − Surprisingly, our suggested drug without any supplementary dressing or tool is capable of keeping an open wound desirably hydrated coordinating wound contraction and re-epithelialization during wound healing. This prominent feature finally results in accelerated skin regeneration.…”

Section: Resultsmentioning

confidence: 99%

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Samie,

Alavian,

Vafaei-Pour

et al. 2023

Mol. Pharmaceutics

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Pharmaceutical cocrystals (Regulatory Classification of Pharmaceutical Co-Crystals Guidance for Industry; Food and Drug Administration, 2018) are crystalline solids produced through supramolecular chemistry to modulate the physicochemical properties of active pharmaceutical ingredients (APIs). Despite their extensive development in interdisciplinary sciences, this is a pioneering study on the efficacy of pharmaceutical cocrystals in wound healing and scar reducing. Curcumin−pyrogallol cocrystal (CUR−PYR) was accordingly cherry-picked since its superior physicochemical properties adequately compensate for limitative drawbacks of curcumin (CUR). CUR− PYR has been synthesized by a liquid-assisted grinding (LAG) method and characterized via FT-IR, DSC, and PXRD analyses. In vitro antibacterial study indicated that CUR−PYR cocrystal, CUR+PYR physical mixture (PM), and PYR are more effective against both Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria in comparison with CUR. In vitro results also demonstrated that the viability of HDF and NIH-3T3 cells treated with CUR−PYR were improved more than those received CUR which is attributed to the effect of PYR in the form of cocrystal. The wound healing process has been monitored through a 15 day in vivo experiment on 75 male rats stratified into six groups: five groups treated by CUR−PYR+Vaseline (CUR−PYR.ung), CUR+PYR+Vaseline (CUR+PYR.ung), CUR+Vaseline (CUR.ung), PYR+Vaseline (PYR.ung), and Vaseline (VAS) ointments and a negative control group of 0.9% sodium chloride solution (NS). It was revealed that the wounds under CUR−PYR.ung treatment closed by day 12 postsurgery, while the wounds in other groups failed to reach the complete closure end point until the end of the experiment. Surprisingly, a diminutive scar (3.89 ± 0.97% of initial wound size) was observed in the CUR−PYR.ung treated wounds by day 15 after injury, followed by corresponding values for PYR.ung (12.08 ± 2.75%), CUR+PYR.ung (13.89 ± 5.02%), CUR.ung (16.24 ± 6.39%), VAS (18.97 ± 6.89%), and NS (20.33 ± 5.77%). Besides, investigating histopathological parameters including inflammation, granulation tissue, reepithelialization, and collagen deposition signified outstandingly higher ability of CUR−PYR cocrystal in wound healing than either of its two constituents separately or their simple PM. It was concluded that desired solubility of the prepared cocrystal was essentially responsible for accelerating wound closure and promoting tissue regeneration which yielded minimal scarring. This prototype research suggests a promising application of pharmaceutical cocrystals for the purpose of wound healing.

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Section: Resultsmentioning

confidence: 99%

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Samie,

Alavian,

Vafaei-Pour

et al. 2023

Mol. Pharmaceutics

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“…For lesion tissue fluid extraction, researchers constructed GelMA/graphene oxide (GO) microneedles using both GelMA and GO, which have strong mechanical properties and swelling capacity to collect 21.34‐μL interstitial skin fluid within 30 min, for analyzing miRNA in the local microenvironment of psoriasis 24 . Furthermore, the multifunctional skin patch prepared by CNTs/graphene/GelMA has good air permeability and swelling due to its porous nanofibrous structure, and it can dynamically monitor wound tension by absorbing interstitial fluid in a rat abdominal skin wound model conditions and humidity changes 25 …”

Section: Collection Of Skin Interstitial Fluidmentioning

confidence: 99%

“…24 Furthermore, the multifunctional skin patch prepared by CNTs/graphene/GelMA has good air permeability and swelling due to its porous nanofibrous structure, and it can dynamically monitor wound tension by absorbing interstitial fluid in a rat abdominal skin wound model conditions and humidity changes. 25…”

Section: Collection Of Skin Interstitial Fluidmentioning

confidence: 99%

Advances in dermatological application of GelMA hydrogel microneedles

Wang

et al. 2023

Skin Research and Technology

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Background Compared with systemic administration methods like injection and oral administration, traditional transdermal drug delivery has the advantages of rapid onset of activity and low side effects. However, hydrophilic drugs and bioactive substances are often unsuitable for traditional transdermal drug delivery. Methods The application of microneedles made from gelatin methylacryloyl (GelMA) has greatly expanded thepossibilities for skin transdermal drug delivery. We have reviewed the latest literatures about the dermatological application of GelMA hydrogel microneedles in recent years using Google Scholar, PubMed and Springer. Results GelMA hydrogel microneedles exhibit huge potency in the diagnosis and treatment of skin diseases, and this technology also brings broad application prospects for subcutaneous micro‐invasive transdermal targeted drug delivery, which mainly used in skin tissue fluid collection, local substance delivery and wound healing. Conclusion With in‐depth research on GelMA hydrogel, this technology will bring more breakthroughs and developments in the clinical diagnosis and treatment of skin diseases.

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“…Moisture is a significant wound biomarker since the excessive exudate would increase the risk of infection. Recently, Li et al [235] reported conductive CNTs and graphene-doped GelMA nanofibrous electronic skin serving as strain and moisture sensors, which provided valuable information about the wound deformation and the amount of wound exudate. When the artificial interstitial fluid was dropped to wet the CNTs/graphene/GelMA membrane, the resistance change rates of mat showed a linear relationship with the increased wetness degree.…”

Section: Electrochemical Detectionmentioning

confidence: 99%

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Dong,

Fu,

et al. 2023

Adv Funct Materials

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Smart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in wound healing and tissue reconstruction. Micro/nanofiber‐based materials are regarded as one of the most promising candidates to develop smart wound dressings owing to their remarkable features including architectural mimicry of extracellular matrix, tunability in structural assembly, and diversity in functionality. Herein, the latest progress of smart micro/nanoscale fiber‐based materials in terms of composition engineering, structural design, and applications in wound management is comprehensively reviewed. This work begins with the advances in smart fibers including stimuli‐responsive fibers, shape memory fibers, and conductive fibers. Then, the structural design of fiber‐based materials from conventional 2D fibrous membrane to emerging 3D fibrous sponge/hydrogel is thoroughly discussed. Furthermore, the applications of smart micro/nanofibrous materials as wound dressings in stimuli‐responsive drug delivery, biomechanical stimulation, electrical stimulation, and wound monitoring are highlighted. Finally, the article offers perspectives on the existing challenges and future directions of smart fibrous materials for wound management.

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Stretchable, conductive, breathable and moisture-sensitive e-skin based on CNTs/graphene/GelMA mat for wound monitoring

Cited by 12 publications

References 62 publications

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Advances in dermatological application of GelMA hydrogel microneedles

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

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