Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test)

Consoli, Daniele; Fedotova, Julia; Micale, Vincenzo; Sapronov, N. S.; Drago, Filippo

doi:10.1016/j.ejphar.2005.08.012

Cited by 53 publications

(43 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is supported by previous studies demonstrating that agents that increase anxiety, including pentylenetetrazol, a corticotropin-releasing factor receptor type 1 (CRF1) agonist, or a diazepam inverse agonist, all decrease immobility time in the FST, similar to the effects observed in the present study (31)(32)(33). In addition, exposure to stress produces a state where subsequent antidepressant treatment increases, instead of decreases, immobility (34). These studies indicate that enhanced anxiety could increase struggling and climbing in the FST and thereby account for the observed decrease in immobility.…”

Section: Behavioral Studiessupporting

confidence: 78%

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda

Segi-Nishida

Newton

et al. 2008

Biological Psychiatry

136

103

View full text Add to dashboard Cite

Background-Postpartum depression (PPD) affects approximately 10% to 20% of women during the first 4 weeks of the postpartum period and is characterized by labile mood with prominent anxiety and irritability, insomnia,and depressive mood. During the postpartum period, elevated ovarian hormones abruptly decrease to the early follicular phase levels that are postulated to play a major role in triggering PPD. However, the underlying neurobiological mechanisms that contribute to PPD have not been determined.

show abstract

Section: Behavioral Studiessupporting

confidence: 78%

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda

Segi-Nishida

Newton

et al. 2008

Biological Psychiatry

136

103

View full text Add to dashboard Cite

show abstract

“…Increased immobility time has been reported during both the proestrus/estrus phase (Contreras et al, 1998;Frye and Walf, 2002;Marvan et al, 1996) and during the diestrus 1 and 2 phases (Barros and Ferigolo, 1998;Consoli et al, 2005). These differences were reported in out-bred and inbred rat strains.…”

Section: Oscillation In Swimming Behavior Across the Ovarian Estrous mentioning

confidence: 70%

“…It has been reported that female rats subjected to the FST display variations in swimming behavior during different phases of the estrous cycle (Barros and Ferigolo, 1998;Consoli et al, 2005;Contreras et al, 1998;Frye and Walf, 2002;Marvan et al, 1996). Increased immobility time has been reported during both the proestrus/estrus phase (Contreras et al, 1998;Frye and Walf, 2002;Marvan et al, 1996) and during the diestrus 1 and 2 phases (Barros and Ferigolo, 1998;Consoli et al, 2005).…”

Section: Oscillation In Swimming Behavior Across the Ovarian Estrous mentioning

confidence: 99%

Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

Tonelli

Holmes

Postolache

2007

Neuropsychopharmacol

116

View full text Add to dashboard Cite

The association between activation of the immune system and mood disorders has been reported by several studies. However, the mechanisms by which the immune system affects mood are only partially understood. In the present study, we detected depressive-like behavior in a rat animal model which involves the induction of inflammation in the nasal cavities by intranasal (i.n.) instillation of bacterial lipopolysaccharides (LPS). Female rats showed depressive-like behavior as evidenced by the forced swim test after repeated i.n. administration of LPS. These responses were not paralleled by alterations in motor activity as measured by the open field test. In the same animals, corticosterone responses after the swimming sessions were the highest of all the groups evaluated. Real-time RT PCR was used to analyze the transcriptional regulation of the cytokines interleukin-1b, tumor necrosis factor-a, and interleukin-6 in several brain regions. Increased tumor necrosis factor-a was detected in the hippocampus and brainstem of female rats challenged with i.n. LPS. These results suggest that peripheral inflammation in the upper respiratory tract is an immune challenge capable of inducing depressive-like behavior, promoting exaggerated glucocorticoid responses to stress, and increasing cytokine transcription in the brain. These results further our understanding of the role that the immune system may play in the pathophysiology of depression.

show abstract

“…Regarding the oestrous cycle, most studies show that the phase of the oestrous cycle does not influence basal female FST behavioural performance in a significant way (Alonso et al, 1991;Bravo and Maswood, 2006;Jans et al, 2007;Tonelli et al, 2008; Andrade et al, 2010;Craft et al, 2010; Allen et al, 2012;Kokras et al, 2012;Flores-Serrano et al, 2013). However, the oestrous cycle could play a role in antidepressant response, but the studies using standard antidepressants in intact female rats during different phases of the cycle are limited (Marvan et al, 1996;Barros and Ferigolo, 1998;Contreras et al, 1998;Consoli et al, 2005; Allen et al, 2012;Dalla et al, 2012;Flores-Serrano et al, 2013). For example, administration of the SSRI sertraline at a low dose (10 mg·kg −1 ) in female rats during the transition from dioestrous to prooestrous results in no antidepressant effect.…”

Section: Sex Differences In Animal Models Of Depressionmentioning

confidence: 99%

“…data). Nevertheless, the effectiveness of antidepressants in reducing immobility and enhancing active behaviours in male and female animals depends on the compound and the selected dosage scheme (Barros and Ferigolo, 1998;Contreras et al, 1998;Consoli et al, 2005;West and Weiss, 2005;Kokras et al, 2009a;Pitychoutis et al, 2011; Allen et al, 2012;Dalla et al, 2012;Flores-Serrano et al, 2013). For instance, with the use of the modified FST, sertraline enhances swimming duration in both sexes , and this has been linked with changes in 5-hydroxytryptaminergic activity (Detke et al, 1995;Detke and Lucki, 1996;Mikail et al, 2012).…”

Section: Sex Differences In Animal Models Of Depressionmentioning

confidence: 99%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

353

187

View full text Add to dashboard Cite

Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

show abstract

Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test)

Cited by 53 publications

References 47 publications

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

Sex differences in animal models of psychiatric disorders

Contact Info

Product

Resources

About