Stressor-specific enhancement of hsp induction by low doses of stressors in conditions of self- and cross-sensitization

Wiegant, F. A. C.; Spieker, Nicole; Wijk, Roeland Van

doi:10.1016/s0300-483x(98)00035-3

Cited by 46 publications

(50 citation statements)

References 37 publications

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“…65 Time factors and prior history also play roles in the direction of effects with homeopathic remedies in animal and cellular models. 22,33,37,66,67 Similarly, seasonal variants (e.g., pollen, temperature, light cycle, and barometric pressures), undocumented differences in menstrual cycles for female participants, or external stress levels for individual subjects over time (e.g., examination-related stress periods in students) could have could each also have confounded the current findings. However, none of those confounding factors was systematically built into the design of this exploratory study.…”

Section: Discussionmentioning

confidence: 89%

“…32 Moreover, animal studies have shown that the direction of response to a given remedy can be biphasic, depending on the state of the recipient at the time of administration. 33 The present study tested the hypotheses that: (1) resting EEG cordance changes in human subjects, after sniffing a specific homeopathic remedy, 34 would fluctuate over sessions, modified by recent exposure history to the agent [35][36][37] ; and (2) the EEG cordance patterns in two different groups of people, each receiving a constititutionally salient homeopathic remedy, would differ from each other, even after controlling for nonhomeopathic baseline subject characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Bell

Howerter

Jackson

et al. 2012

The Journal of Alternative and Complementary Medicine

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Objectives: Electroencephalography (EEG) offers psychophysiologic tools to improve sensitivity for detecting objective effects in complementary and alternative medicine. This current investigation extended prior clinical research studies to evaluate effects of one of two different homeopathic remedies on resting EEG cordance after an olfactory activation protocol on healthy young adults with remedy-relevant, self-perceived characteristics. Methods: Ninety-seven (7) young adults (N = 97, mean age 19 years, 55% women) with good self-rated global health and screened for homeopathic constitutional types consistent with one of two remedies (either Sulphur or Pulsatilla) underwent three weekly laboratory sessions. At each visit, subjects had 5-minute resting, eyes-closed EEG recordings before and after a placebo-controlled olfactory activation task with their constitutionally relevant verum remedy. One remedy potency (6c, 12c, or 30c) used per week, was presented in a randomized order over the 3 sessions. Prefrontal resting EEG cordance values at Fp1 and Fp2 were computed from artifact-free 2-minute EEG samples from the presniffing and postsniffing rest periods. Cordance derives from an algorithm that incorporates absolute and relative EEG values. Results: The data showed significant two-way oscillatory interactions of remedy by time for ß, a, h, and d cordance, controlling for gender and chemical sensitivity. Conclusions: EEG cordance provided a minimally invasive technique for assessing objective nonlinear physiologic effects of two different homeopathic remedies salient to the individuals who received them. Time factors modulated the direction of effects. Given previous evidence of correlations between cordance and single-photon emission computed tomography, these findings encourage additional neuroimaging research on nonlinear psychophysiologic effects of specific homeopathic remedies.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Bell

Howerter

Jackson

et al. 2012

The Journal of Alternative and Complementary Medicine

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Section: Impact After 1 Hour On Injury-related Edema Compared With Samentioning

confidence: 99%

“…That is, the emergent noise derives from the disease itself, i.e., systemic maladaptations or dysfunctions caused by past higher intensity stressors and disease-related factors [99][100][101] (Figure 2). This conceptualization is somewhat similar to the basis for using vaccines in preventive health care.…”

Section: Impact After 1 Hour On Injury-related Edema Compared With Samentioning

confidence: 99%

“…The discrete nanomedicine dose constitutes the pulsed input signal. The result is resistance or cross-resistance (adaptation or cross-adaptation) to same or similar biological stressor or injury, whether they already have occurred or might occur at higher intensities in the future [97][98][99][100][101].The purpose of homeopathic treatment is not to force a specific change in a single target tissue with continuous dosing, in the manner of a conventional bulk form drug. Instead, the intent is to stimulate a cascade of multiple systemic adaptations around the network, all set into motion by the original salient stimulus of a discrete low dose of specific NPs [21].…”

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confidence: 99%

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Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

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The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

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Early Indicators of Response in Biologically Based Risk Assessment for Nongenotoxic Carcinogens

Gastel

2001

Regulatory Toxicology and Pharmacology

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Stressor-specific enhancement of hsp induction by low doses of stressors in conditions of self- and cross-sensitization

Cited by 46 publications

References 37 publications

Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Multiweek Resting EEG Cordance Change Patterns from Repeated Olfactory Activation with Two Constitutionally Salient Homeopathic Remedies in Healthy Young Adults

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Early Indicators of Response in Biologically Based Risk Assessment for Nongenotoxic Carcinogens

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