Stressing out the ER in aminoglycoside-induced hearing loss

García-Huerta, Paula; Rivas, Alexis; Hetz, Claudio

doi:10.1038/cddis.2015.133

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Endoplasmic reticulum stress also plays an important role in aminoglycoside-induced HL. 38 Aminoglycoside antibiotics can bind to the phosphoinositide of the cell membrane to induce arachidonic acid release, resulting in lipid peroxidation and excess reactive oxygen species production, which is associated with cell death. 36 Gentamicin acts as an iron chelator and forms a complex with iron to catalyze the formation of free radicals, thereby damaging hair cells.…”

Section: Ototoxic Drugsmentioning

confidence: 99%

Change to Hearing Loss–Related Risks and Screening in Preterm Infants

2020

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Hearing loss is one of the most common congenital defects in infancy; it increases speech and language delays and adversely affects academic achievement and socialemotional development. The risk of hearing loss in premature infants is higher than that in normal newborns, and because of the fragility of the auditory nervous system, it is more vulnerable to different risk factors. The hearing screening guidelines in current use were proposed by the American Academy of Pediatrics and updated in 2007, but there are no uniform guidelines for hearing screening in preterm infants. This review focuses on the risk factors related to hearing loss in premature infants, hearing screening strategies, and reasons for failure. The aim is to provide a more comprehensive understanding of hearing development in preterm infants to achieve early detection and early intervention. At the same time, attention should be paid to delayed auditory maturation in preterm infants to avoid excessive intervention. Key Points

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Section: Ototoxic Drugsmentioning

confidence: 99%

Change to Hearing Loss–Related Risks and Screening in Preterm Infants

2020

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“…Aminoglycoside (AG) antibiotics have broad‐spectrum bactericidal activity and are used to treat life‐threatening infections in neonates, infants, and adults (Becker & Cooper, 2013; Krause, Serio, Kane, & Connolly, 2016). But all AGs cause toxic side effects, particularly to the kidneys and inner ears (Garcia‐Huerta, Rivas, & Hetz, 2015; Jiang, Karasawa, & Steyger, 2017). The nephrotoxicity is largely reversible and can be clinically managed.…”

Section: Introductionmentioning

confidence: 99%

A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos

Shao

Zhong

Jiang

et al. 2020

J of Applied Toxicology

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Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial activity against both gram‐positive and gram‐negative bacteria. But its toxicity profile analysis is still lacking. In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos. We examined the embryotoxicity, nephrotoxicity, and the damage to the neuromast hair cells. Our results revealed that etimicin and amikacin exhibit more developmental toxicities to the young embryos than gentamicin. But at subtoxic doses, etimicin and amikacin show significantly reduced toxicities towards kidney and neuromast hair cells. We further demonstrated that fluorescently conjugated aminoglycosides (gentamicin‐Texas red [GTTR], amikacin‐Texas red [AMTR], and etimicin‐Texas red [ETTR]) all enter the hair cells properly. Inside the hair cells, gentamicin, not etimicin and amikacin, displays robust reactive oxygen species generation and induces apoptosis. Our data support that the different intracellular cytotoxicity underlies the different ototoxicity of the three aminoglycosides and that etimicin is a new aminoglycoside with reduced risk of nephrotoxicity and ototoxicity.

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