Stressing a tired host: Cryptosporidium species and Helicobacter pylori infections in diabetes mellitus patients with gastrointestinal manifestations

Abdel-Shafi, Iman R.; Fadl, Hanaa; Elsayed, Naglaa M.; El-Gebaly, Naglaa; Rehan, Mohamed

doi:10.21608/puj.2021.92425.1130

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Te StatCalc function of the Epi-Info software version 7.2 (CDC, Atlanta, GA, USA) was used to determine the minimum sample size required for the study. Sample size calculation was performed considering a 95% confdence interval (CI), 80% power, ratio of 2 : 3 between cases and controls, and prevalence of parasitic infection of 27.5% for cases and 12.5% for controls based on an earlier study [25]. A minimum sample size of 137 cases and 96 controls (a total of 233 based on the Fleiss method for calculating sample size for case-control in the Epi-Info software) was determined to be necessary for the study.…”

Section: Sample Size Determination and Study Participantsmentioning

confidence: 99%

Enteric Protozoan Parasitosis and Associated Factors among Patients with and without Diabetes Mellitus in a Teaching Hospital in Ghana

Konadu,

Essuman,

Amponsah

et al. 2023

International Journal of Microbiology

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Background. Enteric protozoa infections (EPIs) could worsen clinical outcomes in patients with diabetes mellitus and therefore requires prompt and accurate diagnosis and attention. This study aimed to determine the burden of EPIs and their associated factors among patients with and without diabetics at the Komfo Anokye Teaching Hospital (KATH) in Ghana. Again, the diagnostic performance of parasitological techniques routinely used for diagnosis was assessed. Methods. A total of 240 participants (made up of 140 patients with diabetes and 100 patients without diabetes) were recruited into the study by simple random sampling from November 2020 to May 2021. Stool samples of participants were collected, along with their demographic information, and examined using the saline direct wet mount (DWM), formol-ether concentration (FEC), and modified Ziehl–Neelsen staining (ZNS) techniques for the presence of enteric protozoans. Results. Enteric protozoa were found among 62/140 (44.3%) diabetic patients and 13/100 (13.0%) nondiabetic patients. The predominant protozoa identified were Cryptosporidium spp. (17.86%) among patients with diabetes and Blastocystis hominis (7.0%) among patients without diabetes. EPI was associated with diabetes mellitus status (AOR = 3.48, 95% CI, 1.55–7.79), having diabetes for more than five years (AOR = 3.83, 95% CI, 1.65–8.86) and having comorbidity (AOR = 2.93, 95% CI, 1.33–6.45). The FEC technique had the highest sensitivity (100.0%), specificity 94.3% (95% CI, 91.35–97.22), and accuracy 95.0% (95% CI, 88.54–98.13) when compared to other techniques for diagnosis. Conclusion. EPIs are a significant health problem among patients with diabetes at KATH, and therefore antiparasitic drugs should be included in their treatment protocols for better health outcomes. Again, the FEC technique has demonstrated better performance in detecting EPIs and is therefore recommended to achieve early and accurate diagnosis of EPIs.

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Section: Sample Size Determination and Study Participantsmentioning

confidence: 99%

Enteric Protozoan Parasitosis and Associated Factors among Patients with and without Diabetes Mellitus in a Teaching Hospital in Ghana

Konadu,

Essuman,

Amponsah

et al. 2023

International Journal of Microbiology

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Prevalence of intestinal parasitic infections in patients with diabetes: a systematic review and meta-analysis

Taghipour

Javanmard

Rahimi

et al. 2023

International Health

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Patients with diabetes are at an increased risk of intestinal parasitic infections (IPIs). We evaluated the pooled prevalence and OR of IPIs in patients with diabetes through a systematic review and meta-analysis. A systematic search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for studies reporting IPIs in patients with diabetes through 1 August 2022. The collected data were analyzed using comprehensive meta-analysis software version 2. Thirteen case-control studies and nine cross-sectional studies were included in this study. The overall prevalence of IPIs in patients with diabetes was calculated to be 24.4% (95% CI 18.8 to 31%). Considering the case-control design, the prevalence of IPIs in case (25.7%; 95% CI 18.4 to 34.5%) was higher than controls (15.5%; 95% CI 8.4 to 26.9%) and a significant correlation was observed (OR, 1.80; 95% CI 1.08 to 2.97%). Moreover, a significant correlation was seen in the prevalence of Cryptosporidium spp. (OR, 3.30%; 95% CI 1.86 to 5.86%), Blastocystis sp. (OR, 1.57%; 95% CI 1.11 to 2.22%) and hookworm (OR, 6.09%; 95% CI 1.11 to 33.41%) in the cases group. The present results revealed a higher prevalence of IPIs in patients with diabetes than in controls. Therefore, the results of this study suggest a proper health education program to preventing measures for the acquisition of IPIs in patients with diabetes.

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Stressing a tired host: Cryptosporidium species and Helicobacter pylori infections in diabetes mellitus patients with gastrointestinal manifestations

Abstract: Cryptosporidium is an obligatory intracellular protozoan that parasitizes gastrointestinal epithelial cells. The parasites develop principally in the jejunum and ileum under the brush border of the epithelial cells [13] . Globally, the number of reported cases of

Cited by 2 publications

References 48 publications

Enteric Protozoan Parasitosis and Associated Factors among Patients with and without Diabetes Mellitus in a Teaching Hospital in Ghana

Enteric Protozoan Parasitosis and Associated Factors among Patients with and without Diabetes Mellitus in a Teaching Hospital in Ghana

Prevalence of intestinal parasitic infections in patients with diabetes: a systematic review and meta-analysis

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