Stress urinary incontinence in women and cell therapy: What can we expect from the future?

Zambon, João Paulo; Magalhaes, Renata S.; Almeida, Fernando G.

doi:10.5410/wjcu.v3.i3.304

Cited by 1 publication

(5 citation statements)

References 29 publications

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“…By definition, mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cells, such as chondrocytes, myocytes, and adipocytes. MSCs can be isolated from all tissues derived from mesoderms, such as bone marrow, amniotic fluid, blood, adipose, cartilage, and skeletal muscle tissue …”

Section: Methodsmentioning

confidence: 99%

“…Adipose tissue is an abundant source of MSCs that can be easily harvested in large number with low morbidity. Adipose derived stem cells (ADSCs) exhibit stable growth and proliferation kinetics and can differentiate toward osteogenic, chondrogenic, adipogenic, myogenic, or neurogenic lineages in vitro …”

Section: Methodsmentioning

confidence: 99%

“…Regenerative medicine is a branch of translational research in tissue engineering and molecular biology that deals with the “process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.” It holds the premise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs (Figure ).…”

Section: Methodsmentioning

confidence: 99%

“…MSCs can be isolated from all tissues derived from mesoderms, such as bone marrow, amniotic fluid, blood, adipose, cartilage, and skeletal muscle tissue. 23 Bone marrow-derived stem cells (BMSC) have a great capacity for self-renewal while maintaining pluripotency. Kinebuchi abdominal leak point pressure (ALPP).…”

Section: Stem Cells-based Therapy For Suimentioning

confidence: 99%

“…Adipose derived stem cells (ADSCs) exhibit stable growth and proliferation kinetics and can differentiate toward osteogenic, chondrogenic, adipogenic, myogenic, or neurogenic lineages in vitro. 23 ADSCs have been tested in preclinical studies in murine, 11,13,15 rabbits, 12 and porcine 16 SUI models. Silwal Gautam et al demonstrated that the implantation of ADSCs into cryoinjured female rabbit urethras promoted the recovery of urethral function by myogenic differentiation as well as neuroregeneration.…”

Section: Adipose Tissue-derived Stem Cells For Suimentioning

confidence: 99%

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Applicability of regenerative medicine and tissue engineering for the treatment of stress urinary incontinence in female patients

Zambon

Williams

Bennington

et al. 2019

Neurourology and Urodynamics

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Stress urinary incontinence (SUI) is an age health‐related issue that generates interest due to its considerable public health burden and the controversies surrounding treatment. It is highly prevalent affecting 30–40% of all women during their lifetime. Midurethral slings are the standard of gold standard treatment for female patients with SUI. They have excellent short‐term cure rates; however, their efficacy tends to decrease over time and patients often report urinary incontinence recurrence. This paper addresses the applicability of regenerative medicine and tissue engineering for the treatment of SUI in female patients. Cell‐based treatment with periurethral injection of autologous adipose or muscle‐derived stem cells have been used for SUI; however, the cure rates and SUI recurrence at 1 year were 40% and 70%, respectively. Novel minimally invasive approaches, such as low‐intensity extracorporeal shock wave therapies have shown promising results in SUI animal models. In addition, local injection of growth factors, chemokines, and specific antibodies have shown histological evidence of neoangiogenesis, nerve, and sphincter regeneration in rodents and nonhuman primates with SUI. The use of bioactive factors and proteins secreted by cells, which is called secretomes, have been recognized as key regulators of various mechanisms, such as immunomodulation, angiogenesis, inflammation, apoptosis, and tissue repair. Emerging therapies aiming to replace or restore tissues and organ functionality may improve the long‐term efficacy and in the near future may represent the standard of care for the treatment of SUI.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Stem Cells-based Therapy For Suimentioning

confidence: 99%