Stress urinary incontinence and endogenous sex steroids in postmenopausal women

Augoulea, Areti; Sioutis, Dimos; Rizos, Demetrios; Panoulis, Constantinos; Triantafyllou, Nikolaos; Armeni, Eleni; Deligeoroglou, Efthymios; Chrelias, Charalambos; Creatsa, Maria; Liapis, Angelos; Lambrinoudaki, Ιrene

doi:10.1002/nau.22885

Cited by 34 publications

(28 citation statements)

References 35 publications

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“…A power analysis was conducted using the software GPOWER [19]. To reach a power of 95%, an overall sample size of 84 women was calculated with an a level of 0.05 and an effect size derived from previously reported serum E2 levels of 17.30 (AE8.16) pg/mL for postmenopausal women with SUI and 24.22 pg/mL (AE8.99) for postmenopausal women without SUI [1]. To account for any dropouts and measurement errors we increased the sample size by 10% to a final sample size of 94 women in all.…”

Section: Discussionmentioning

confidence: 99%

“…Female stress urinary incontinence (SUI), the most common type of incontinence, is defined as a complaint of involuntary loss of urine with effort or physical exertion, or on sneezing or coughing [1,2]. Several established risk factors are described in the literature, such as mode of delivery in giving birth, parity, chronic cough, obesity, connective tissue dysfunction and menopause [1,3,4]. There is epidemiological evidence from several studies implicating menopause and subsequent oestrogen deficiency in the pathogenesis of a number of urinary complaints, including incontinence.…”

Section: Introductionmentioning

confidence: 99%

“…Ahn et al [9] reported an inverse correlation of serum oestradiol (E2) levels and urethral hypermobility, a major mechanism underlying SUI, while Bai et al [10] described a positive correlation between bladder neck hypermobility and SUI [9,10]. Augoulea et al [1] reported significantly lower circulating E2 levels in women with SUI compared with women without SUI [1]. By contrast, one Swedish study in >6,000 peri-and postmenopausal women showed that higher circulating oestrogen levels are associated with UI of any type [12].…”

Section: Introductionmentioning

confidence: 99%

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Role of serum steroid hormones in women with stress urinary incontinence: a case–control study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of serum steroid hormones in women with stress urinary incontinence: a case–control study

et al. 2017

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“…Therefore, a direct effect of TSH on structures of the lower urogenital tract could be assumed. Considering that the post‐menopausal women participants in this study did not have hormonal replacement, the actions of TSH on genitourinary structures could occur with independence of those coming from oestrogens . Since our present findings, the pharmacological therapy prescribed to reduce TSH levels could alleviate some urinary symptoms in post‐menopausal women.…”

Section: Discussionmentioning

confidence: 56%

Moderate‐to‐high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years

Cuevas-Romero

Sanchez-Cardiel

Zamora-Gallegos

et al. 2017

Clin Exp Pharma Physio

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SummaryThe present study aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and/or cancer were enrolled as participants. Anthropometric indicators, serum glucose and estradiol, and thyroid profile were measured. Sociodemographic, clinical, physical activity, and quality of life surveys were applied. One-hour pad test and International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) were used to determine UI.Urinalysis was also done. In agreement with results from the pad test (cut-off point ≥1.4 g), the ICIQ-SF reveled approximately 50% of incontinent women. A high percentage of women had moderate-high bacteriuria and urinary infections. Logistic regression analysis showed that age is a risk factor for both UI and urinary infection.Diabetes, number of pregnancies or childbirths, urinary infections, and bacteriuria did not influence the presence of UI. To allocate women into four groups according to their age (<65 or ≥65 years old) and TSH concentrations (0.3-1.9 or 2-10 μUI/mL), we found that moderate-to-high normal levels of TSH is a risk factor for UI and a worse quality of life in the oldest women. Our results highlight the profit of measuring TSH concentrations in post-menopausal women. K E Y W O R D Sageing, ICIQ-SF, pad test, quality of life, thyroid hormones, thyrotropin | INTRODUCTIONPost-menopause is linked to an impaired function of the genitourinary tract. Thus, vulvovaginal atrophy, sexual dysfunctions, urine retention, urinary incontinence (UI), renal dysfunctions, and urinary infections are common among post-menopausal women.1-9 Moreover, genitourinary dysfunctions worsen the quality of life of women. 10,11Post-menopausal women also have a high prevalence of clinical and subclinical hypothyroidism.

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“…Age, obesity, lung disease (e.g. chronic cough), gravidity, hypertension and menopause are known to be risk factors for stress UI in women . Additionally, DM and stroke are risk factors for UI, resulting from neurogenic bladder.…”

Section: Introductionmentioning

confidence: 99%

Nutrient intake and urinary incontinence in Korean women: A propensity score‐matched analysis from the Korea National Health and Nutrition Examination Survey data

Lee

2017

Int J of Urology

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Objectives: To evaluate the relationship between dietary nutrients and female urinary incontinence using nationally representative data from Korea. Methods: We included 8090 women aged >20 years who had participated in the Korea National Health and Nutrition Examination Survey IV. We carried out a propensitymatched study by identifying women with urinary incontinence. Women without urinary incontinence, matched for age, body mass index, menopause, delivery history, hypertension, diabetes, hypercholesterolemia, stroke, asthma, chronic obstructive pulmonary disease and amount of total food intake, were included as a control group at a 2:1 ratio (661 women with urinary incontinence; 1322 women without urinary incontinence). Data were analyzed using the v 2 -test, Mann-Whitney test, Fisher's exact test and logistic regression. Results: Following propensity score matching, 661 women with urinary incontinence and 1322 women without urinary incontinence were included; the confounders were evenly dispersed and did not differ significantly between the groups. There was no significant difference in the intake of water, fat, protein, calcium, phosphorus, iron, sodium, potassium, vitamin A, carotene, riboflavin, niacin and vitamin C. However, carbohydrate intake was significantly higher in the urinary incontinence group than in the control group (median [interquartile range]: 282.3 g/day [214.7; 352.0] vs 267.7 g/day [212.6; 339.1]; P = 0.041). Conclusion: High carbohydrate intake seems to be significantly related to female urinary incontinence in the Korean population.

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Stress urinary incontinence and endogenous sex steroids in postmenopausal women

Abstract: These results may indicate that within the postmenopausal range, endogenous sex hormones may be associated with the presence of SUI in women not on menopausal hormone therapy. Neurourol. Urodynam. 36:121-125, 2017. © 2015 Wiley Periodicals, Inc.

Cited by 34 publications

References 35 publications

Role of serum steroid hormones in women with stress urinary incontinence: a case–control study

Role of serum steroid hormones in women with stress urinary incontinence: a case–control study

Moderate‐to‐high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years

Nutrient intake and urinary incontinence in Korean women: A propensity score‐matched analysis from the Korea National Health and Nutrition Examination Survey data

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