Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding

Sochet, Anthony A.; Son, Sorany; Ryan, Kelsey; Roddy, Meghan; Barrie, Eddie; Wilsey, Michael; McKinley, Scott; Nakagawa, Thomas A.

doi:10.1080/02770903.2019.1614617

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…( Duffett et al, 2020 ) The benefits among pediatric patients are inconsistent, with some studies reporting a decrease in GI bleeding and others failing to find a significant reduction. ( Abu El-Ella et al, 2021 , Reveiz et al, 2010 , Sochet et al, 2020 ) This might be explained, in part, by the fact that although GI bleeding is common in critically ill pediatric patients, the rate of clinically significant bleeding remains very low. ( Abu El-Ella et al, 2021 , Chaïbou et al, 1998 ) Data regarding the benefits and risks of PPIs as SUP in noncritically ill pediatric patients are lacking, necessitating a more cautious approach to the routine use of PPIs beyond the ICU.…”

Section: Discussionmentioning

confidence: 99%

Appropriateness of proton pump inhibitors use in noncritically ill hospitalized children in a tertiary hospital in Saudi Arabia

Alosaily,

Alfallaj,

Alabduljabbar

et al. 2023

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Appropriateness of proton pump inhibitors use in noncritically ill hospitalized children in a tertiary hospital in Saudi Arabia

Alosaily,

Alfallaj,

Alabduljabbar

et al. 2023

Saudi Pharmaceutical Journal

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“…However, the incidence of clinically significant gastrointestinal bleeding in children remains low [58] and there are risks for potential harm from SUP administration such as NEC, Clostridium difficile infection or nosocomial pneumonia [59,60]. A single-center retrospective cohort study, including patients on systemic corticosteroids for status asthmaticus reported no gastrointestinal bleeding [61]. A systematic review on SUP administration, observed no significant difference in gastrointestinal bleeding rates between SUP administration and no prophylaxis [62].…”

Section: Andandmentioning

confidence: 99%

Challenges and advances in nutrition for the critically ill child

Albert

Martinez

2022

Current Opinion in Critical Care

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Purpose of reviewMalnutrition remains prevalent in critically ill children and is associated with worse clinical outcomes. Conversely, nutrition provision has been associated with improved survival. Nutritional challenges must be addressed to guide best nutrition practices for the critically ill child. In this narrative review, we summarize findings from research published between July 2020 and January 2022 on nutrition in critically ill children. Findings from these articles build on previous work to guide next steps in both research and clinical practice in this cohort.Recent findingsA comprehensive literature review was performed. We identified the following common themes for research published between July 2020 and January 2022-metabolism, enteral nutrition, including timing, dosing, protein prescription and delivery in special populations, gastrointestinal function, and enteral nutrition adjunctive therapies.SummaryResearch continues to support early initiation and advancement of enteral nutrition. Achieving nutritional adequacy is challenging, but research associated with the timing and dosing of enteral nutrition, alternative methods of enteral nutrition delivery and the use of adjuncts are expanding our understanding of best practices for this cohort. Areas for further research continue to be the use of measured energy requirements, protein dosing and inclusion of functional outcomes to assess the benefit of nutritional interventions.

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Dose‐dependent protective effects of Lactobacillus rhamnosus GG against stress‐induced ulcer

Işık,

Özbayer,

Dönmez

et al. 2024

J Sci Food Agric

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BACKGROUNDStress‐related diseases are on the rise and stress is one of the common factors that lead to ulcer. Stress‐induced mucosal bleeding is a serious complication observed in many critically ill patients. Due to the harmful side effects of proton pump inhibitors, natural and active alternative treatment methods for peptic ulcer treatment that are safe in terms of side effects are an urgent need for human health. We aimed to investigate the dose‐dependent protective effects of Lactobacillus rhamnosus GG (LGG) against stress ulcers induced by cold restraint stress in rats. This study was performed in a total of 42 rats, in control group (C), stress group (S), pantoprazol (20 mg kg−1 day−1) group (P), LGG (3 × 108 cfu mL−1 day−1) + stress group (M1), LGG (15 × 108 mL−1 day−1) + stress group (M5) and LGG (30 × 108 mL−1 day−1) + stress group (M10) (each n = 7). Ulceration areas (mm2) were determined quantitatively with ImageJ software. Glucocorticoid, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were determined by ELISA and malondialdehyde levels were determined by spectrophotometric measurement. Histopathological examinations were performed in gastric tissue.RESULTSTherapeutic dose of LGG increased CAT, SOD and GPx levels; prevented excessive activation of the hypothalamic–pituitary–adrenal axis; reduced ulceration and bleeding in the gastric mucosal layer; and provided stabilization of mast cells.CONCLUSIONSWe can suggest that LGG may be beneficial for reducing the negative effects of stress on the body, for protecting against ulcer disease and for reducing or preventing the risk of stress‐induced gastrointestinal bleeding in patients staying in intensive care units. © 2024 The Author(s). Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding

Cited by 8 publications

References 34 publications

Appropriateness of proton pump inhibitors use in noncritically ill hospitalized children in a tertiary hospital in Saudi Arabia

Appropriateness of proton pump inhibitors use in noncritically ill hospitalized children in a tertiary hospital in Saudi Arabia

Challenges and advances in nutrition for the critically ill child

Dose‐dependent protective effects of Lactobacillus rhamnosus GG against stress‐induced ulcer

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