Stress-tolerance tests and postprandial low-grade inflammation response

Vankova, Deyana; Nazifova-Tasinova, Neshe; Kiselova-Kaneva, Yoana; Ivanova, Diana

doi:10.14748/ssp.v1i1.1733

Cited by 2 publications

(5 citation statements)

References 30 publications

(16 reference statements)

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“…However, we identified three studies in which a total of 51 people were given elderberry products and cytokine production was subsequently assessed (ex vivo studies). One of these studies was an RCT [ 37 ] comparing 12 weeks of either elderberry or placebo in 52 healthy post-menopausal women, one study was a single-arm cohort study [ 38 ] in which 22 healthy volunteers drank Sambucus ebulus (i.e. European dwarf elderberry) tea for 30 days, and one study evaluated cytokines before and after single oral doses of both diclofenac and elderberry [ 15 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…TNF-alpha levels were 80.3 ± 2.0 at 2 h, 98.0 ± 14.1 at 4 h, and 121.7 ± 21.6 at 8 h. The decrease was significant (p < 0.05) only at 2 h. With diclofenac, IL-1 levels were 78.0 ± 5.5 at 2 h, 73.3 ± 7.9 at 4 h, and 51.0 ± 21.8 at 8 h and TNF-alpha levels were 80.0 ± 10.0 at 2 h, 88.0 ± 7.5 at 4 h, and 61.3 ± 6.6 at 8 h. The effects of diclofenac were significant (p < 0.05) for both cytokines at each time point. Ivanova 2015 [ 38 ] Before and after study N = 22 healthy volunteers drank elderberry tea for 30 days. Cytokines were measured at baseline and after treatment.…”

Section: Resultsmentioning

confidence: 99%

“…There was no other apparent risk of bias. We considered the interrupted time series rating to be the most appropriate EPOC tool for rating the risk of bias for the single-arm cohort study assessing cytokines before and after 30 days of elderberry tea (Ivanova 2015) [ 38 ] and we rated the study as low risk of bias in all domains. We considered the controlled before and after rating to be the most appropriate EPOC tool for rating the risk of bias for the study comparing cytokines before and after elderberry and diclofenac (Kirichenko 2016) [ 15 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…A before-and-after study reported on 22 healthy volunteers who drank a 200 ml elderberry infusion (an approximate dose of 3.66 mg anthocyanins per liter) for 30 days. This study suggests that there is evidence for statistically significantly lower serum CRP and IL-beta levels after 30 days of elderberry intake, but little to no difference in IL-6 and TNF-alpha [ 38 ]. Finally, after a single administration of 2.5 g of black elderberry tincture was given to 3 healthy volunteers, there was a statistically significant reduction from baseline in IL-6 levels measured at 2, 4 and 8 h and a statistically significant reduction from baseline in TNF-alpha levels at 2 h, but not at 6 or 8 h [ 15 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review

Wieland

Piechotta

Feinberg

et al. 2021

BMC Complement Med Ther

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Background Elderberry has traditionally been used to prevent and treat respiratory problems. During the COVID-19 pandemic, there has been interest in elderberry supplements to treat or prevent illness, but also concern that elderberry might overstimulate the immune system and increase the risk of ‘cytokine storm’. We aimed to determine benefits and harms of elderberry for the prevention and treatment of viral respiratory infections, and to assess the relationship between elderberry supplements and negative health impacts associated with overproduction of pro-inflammatory cytokines. Methods We conducted a systematic review and searched six databases, four research registers, and two preprint sites for studies. Two reviewers independently assessed studies for inclusion, extracted data from studies, assessed risk of bias using Cochrane tools, and evaluated certainty of estimates using GRADE. Outcomes included new illnesses and the severity and duration of illness. Results We screened 1187 records and included five randomized trials on elderberry for the treatment or prevention of viral respiratory illness. We did not find any studies linking elderberry to clinical inflammatory outcomes. However, we found three studies measuring production of cytokines ex vivo after ingestion of elderberry. Elderberry may not reduce the risk of developing the common cold; it may reduce the duration and severity of colds, but the evidence is uncertain. Elderberry may reduce the duration of influenza but the evidence is uncertain. Compared to oseltamivir, an elderberry-containing product may be associated with a lower risk of influenza complications and adverse events. We did not find evidence on elderberry and clinical outcomes related to inflammation. However, we found evidence that elderberry has some effect on inflammatory markers, although this effect may decline with ongoing supplementation. One small study compared elderberry to diclofenac (a nonsteroidal anti-inflammatory drug) and provided some evidence that elderberry is as effective or less effective than diclofenac in cytokine reduction over time. Conclusions Elderberry may be a safe option for treating viral respiratory illness, and there is no evidence that it overstimulates the immune system. However, the evidence on both benefits and harms is uncertain and information from recent and ongoing studies is necessary to make firm conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review

Wieland

Piechotta

Feinberg

et al. 2021

BMC Complement Med Ther

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“…SIO intake was associated with IL‐6 decrease in serum, principally for the MH group probably due to a higher sensitivity to anti‐inflammatory action in the absence of metabolic disorders (Vankova, Nazifova, Kiselova, & Ivanova, ). This is the first study to show the effect of SIO on IL‐6 levels on postprandial stages, although similar results have been reported with chronic supplements using other n‐3 fatty acids (Kiecolt et al, ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic status is related to the effects of adding of sacha inchi (Plukenetia volubilis L.) oil on postprandial inflammation and lipid profile: Randomized, crossover clinical trial

2018

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Sacha inchi oil (SIO) is an attractive source of polyunsaturated acids oil. A randomized crossover clinical trial was done to evaluate SIO effects on postprandial lipids and inflammatory state caused by a high‐fat intake. Twenty metabolically healthy (MH) and 22 metabolically unhealthy (MU) subjects consumed a high‐fat breakfast alone or supplemented with SIO. The biomarkers were measured in serum upon fasting, and after 1 and 4 hrs after breakfast. Interleukin‐6 (IL‐6) expression was determined in mononuclear cells. In the MH group, SIO reversed the cholesterol increase [iAUCHFM: 0.27 mmol/L/4 h (IQR: −0.07/0.81); iAUCHFM+S: −0.18 mmol/L/4 h (IQR: −0.49/0.31) p = 0.037] and decreased interleukin‐6 concentration. In MU group, SIO attenuated lipopolysaccharides increase and interleukin‐6 expression [(FCHFM = −1.19 (IQR: −1.72/1.93) and FCHFM+S = −1.83 (IQR: −4,82/−0.01), p = 0.017]. The effects of a high‐fat meal on postprandial lipids and inflammation could be modified by the addition of SIO, but the outcomes are depending on the metabolic individual status. Practical applications The seeds of Plukenetia volubilis L., also known as Sacha inchi, Sacha peanut or Inca peanut are an attractive vegetable source of oil which includes a high content of polyunsaturated fatty acids. Furthermore, the intake of Sacha inchi oil could improve the postprandial responses of a high‐fat intake, and could be able to help to prevent cardiovascular diseases. Our results contribute to know the effects of this oil on postprandial inflammation and lipids. In addition, establishing how a person’s basal metabolic status can determinate the metabolic response to this oil can help improve its use, and our results add evidence about the role of nutrition and diet in health and disease. At this time, the cultivation of Sacha inchi is being proposed as an agro‐industrial alternative for the improvement of quality of living in Colombian rural areas.

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Stress-tolerance tests and postprandial low-grade inflammation response

Cited by 2 publications

References 30 publications

Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review

Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review

Metabolic status is related to the effects of adding of sacha inchi (Plukenetia volubilis L.) oil on postprandial inflammation and lipid profile: Randomized, crossover clinical trial

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