Stress spectrum disorders in oncology

Desaive, P; Ronson, Alain

doi:10.1097/cco.0b013e328302166a

Cited by 21 publications

(13 citation statements)

References 52 publications

(62 reference statements)

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“…It is known that catecholamine hyperactivity and glucocorticoid disregulation are the biological consequences of chronic stress (Desaive and Ronson, 2008). The results of this study show that long-term treadmill running produced adaptive physiological changes which are indicative for chronic stress.…”

Section: Changes In the Plasma Concentrations Of Cort Na A And Weigmentioning

confidence: 51%

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Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats

Gavrilović¹,

Stojiljković²,

Kasapović³

et al. 2012

Acta vet (Beogr)

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In this study we examined how chronic forced running (CFR) affects the expression of catecholamine biosynthetic enzymes and cAMP response element-binding (CREB) in the adrenal medulla and the weight of adrenal glands of rats. Also, we examined how CFR and additional acute immobilization stress affect the expression of catecholamine biosynthetic enzymes in the adrenal medulla and the concentration of catecholamines and corticosterone (CORT) in the blood plasma. In this experiment we used as a model forced exercise in rats (treadmill running). We used the most advanced method for determining the level of gene expression, Real-time PCR with TaqMan probes, as well as Western blot analysis (ECL). We found that CFR decreases tyrosine hydroxylase (TH), and dopamine-β-hydroxylase (DBH) mRNA and protein levels in the adrenal medulla. The decreased TH and DBH mRNA levels coincide with the reduced expression of CREB in the adrenal medulla and with the reduced plasma CORT level. Additionally, CFR reduces the level of phenylethanolamine N-methyltransferase (PNMT) mRNA, but elevates its protein level in the adrenal medulla and increases the concentration of adrenaline (A) in the plasma. Reduced level of PNMT mRNA in the adrenal medulla coincides with reduced plasma CORT level. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. The increased synthesis of PNMT enzyme in the adrenal medulla may result in an increased biosynthesis of A under chronic stress conditions. Additionally, increased level of catecholamines in the plasma after chronic physical stress is the allostatic load that may induce numerous diseases and pathological conditions

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Section: Changes In the Plasma Concentrations Of Cort Na A And Weigmentioning

confidence: 51%

“…Reverse transcription was performed using Ready-To-Go You-Prime First-Strand Bead (Amersham Biosciences, UK) and pd (N) 6 Random Hexamer (Amersham Biosciences, UK) primer according to the manufacturer's protocol. After the isolation of mRNA, DNA-ase treatment was applied with DNAse I (Fermentas, Lithuania).…”

Section: Rna Isolation and Cdna Synthesismentioning

confidence: 99%

Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats

Gavrilović¹,

Stojiljković²,

Kasapović³

et al. 2012

Acta vet (Beogr)

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“…Cancer patients have very high chronic stress responses caused by psychosocial distress [20,21]. The biological consequences of cumulative stress include catecholamine hyperactivity of the sympathetic nervous system (SNS) response [22], and the SNS plays a key role in the activation of BAT. Our study, which reduced the interference of low outdoor temperature, further demonstrates that more active neoplastic status was associated with more vigorous TMA of BAT.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

et al. 2011

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BackgroundBrown adipose tissue (BAT) has thermogenic potential. For its activation, cold exposure is considered a critical factor though other determinants have also been reported. The purpose of this study was to assess the relationship between neoplastic status and BAT activity by 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in people living in the tropics, where the influence of outdoor temperature was low.Methods18F-FDG PET/CT scans were reviewed and the total metabolic activity (TMA) of identified activated BAT quantified. The distribution and TMA of activated BAT were compared between patients with and without a cancer history. The neoplastic status of patients was scored according to their cancer history and 18F-FDG PET/CT findings. We evaluated the relationships between the TMA of BAT and neoplastic status along with other factors: age, body mass index, fasting blood sugar, gender, and outdoor temperature.ResultsThirty of 1740 patients had activated BAT. Those with a cancer history had wider BAT distribution (p = 0.043) and a higher TMA (p = 0.028) than those without. A higher neoplastic status score was associated with a higher average TMA. Multivariate analyses showed that neoplastic status was the only factor significantly associated with the TMA of activated BAT (p = 0.016).ConclusionsNeoplastic status is a critical determinant of BAT activity in patients living in the tropics. More active neoplastic status was associated with more vigorous TMA of BAT.

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“…Anxiety is well documented in patients with the diagnosis of cancer and the initiation of treatment (10)(11)(12)(13). Patients are confronted with the worry of death at the time of diagnosis.…”

Section: Anxietymentioning

confidence: 99%

“…Among the various types of psychological responses, anxiety and depression received most attention in the studies of cancer patients (10). Anticipatory anxiety and post traumatic stress disorder are the two types of anxiety known to be related to the initiation and consequence of cancer treatment (10)(11)(12)(13). Depression encompasses a spectrum that ranges from normal sadness to major depressive disorder.…”

Section: Introductionmentioning

confidence: 99%

Psychological Distress Among Cancer Patients on Chemotherapy

2010

JUMMEC

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Distress has become a major issue in cancer population. Patients may suffer from either physical, psychological distress or both. Cancer patients who are undergoing chemotherapy are more likely to experience psychological distress. This could be due to the negative effects of chemotherapy agents, the uncertainty of post-treatment, and the occurrence of psychosocial problems. As a result, the patient may experience a normal reaction such as sadness or may develop common psychiatric disorders such as depression and anxiety.

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Stress spectrum disorders in oncology

Cited by 21 publications

References 52 publications

Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats

Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats

The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

Psychological Distress Among Cancer Patients on Chemotherapy

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