Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study

Bergström, Anders; Jayatissa, Magdalena Niepsuj; Mørk, Arne; Wiborg, Ove

doi:10.1016/j.brainres.2007.12.025

Cited by 174 publications

(123 citation statements)

References 59 publications

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“…This is a standard definition of anhedonia-like behavior in CMS rat studies (3, 4, 6 -8, 12-14, 33, 34, 39 -42, 55, 57). The anhedonic-like behavior correlates strongly with other depression markers (3,12,33).…”

Section: Methodsmentioning

confidence: 79%

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Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Matchkov VV, Kravtsova VV, Wiborg O, Aalkjaer C, Bouzinova EV. Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression. Am J Physiol Regul Integr Comp Physiol 309: R814 -R823, 2015. First published August 12, 2015 doi:10.1152/ajpregu.00337.2014.-Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with Ͼ30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CMS-susceptible and compared with unstressed controls. Sixteen CMS-susceptible and eight unstressed rats were treated during weeks 5 to 8 of the CMS protocol with escitalopram. Escitalopram-treated rats with Ͼ20% recovery in the sucrose consumption during the last 2 wk of treatment were defined as escitalopram responders. Rats that did not reach these criteria were defined as escitalopram nonresponders. In the open field test, escitalopram responders demonstrated anxiolytic effect of treatment. In mesenteric small arteries, escitalopram affected neither NO nor cyclooxygenase-1 (COX-1)-mediated vasodilation. Escitalopram potentiated endothelium-dependent hyperpolarization-like response, which was suppressed in the vehicle-treated CMS-susceptible rats and reduced COX-2-dependent relaxation, which was elevated in the vehicle-treated CMS-susceptible rats. Escitalopram did not affect blood pressure and heart rate, which were elevated in the vehicle-treated CMS-susceptible rats. Oxidative stress markers were changed in association with CMS in liver, heart, and brain. Escitalopram normalized oxidative stress markers in the majority of tissues. This study demonstrates that the antidepressant effect of escitalopram is associated with partial improvement of endothelial function in small arteries affecting COX-2 and endothelium-dependent hyperpolarization-like pathways.depression; chronic mild stress; escitalopram; endothelium; nitric oxide synthase; cyclooxygenase; endothelium-derived hyperpolarization; oxidative stress; glutathione; malondialdehyde CARDIOVASCULAR DISEASES AND major depressive disorder are the two most prevalent health problems in high-income countries (31). Their comorbidity is well recognized, but the mechanisms and critical factors underlying this comorbidity are unknown. Interactions between several factors common for both disorders are complex (17; 43). Thus, a dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and activation of the renin-angiotensin-aldosterone system lead to changes associated with both depression and cardiovascular abnormalities.Also dysfunction of the autonomic nervous system (sympathetic/parasympathetic) is known to be involved, as well as an activation of proinflammatory cytokines (46). Importantly, these factors can induce both depression and ch...

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Section: Methodsmentioning

confidence: 79%

“…The baseline sucrose consumption was measured during 3 wk. Then rats were divided into two groups, where one group was exposed to CMS for 8 wk and the other remained unchallenged (3,7,8,13,14,33,34,36,41,42,57 SCT. SCT measures the sucrose intake of individual rats during 1-h exposure to a bottle with 1.5% sucrose solution.…”

Section: Methodsmentioning

confidence: 99%

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…이 실험방법의 특징은 실험동물이 예측할 수 없는 경미한 스트레스를 반복적으로 부여함으로써 습관화가 나타나지 않도 록 한다는 것이며, CMS 과정이 3주 이상 지속된 실험동물의 육안적 행동양상으론 체중 감소, 자당용액에 대한 선호도 또 는 섭취량 감소가 나타난다 (Willner et al, 1987). 자당용액 의 섭취 또는 선호도가 줄어드는 것은 보상에 대한 흥미가 줄 어드는 것을 반영하는 것이며, 이는 우울증에서 나타나는 여 러 증상 중 무쾌감증과 같이 외부적 반응에 대한 반응 감소 행동 양상으로 볼 수 있다 (Bergstrom et al, 2008;Willner, 2005;Papp et al, 1991).…”

Section: 오미자 추출물의 항우울 효과unclassified

Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress

Kang¹,

Kim²,

Im³

et al. 2014

Korean Journal of Medicinal Crop Science

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: Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. 'anhedonic' behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200 ㎎/㎏ significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.

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“…VEGF is involved in the neurovascular stem cell niche in the subgranular zone of the dentate gyrus of the hippocampus and affects synaptic plasticity in hippocampus-dependent processes such as learning and memory [121]. Similarly to BDNF, VEGF protein expression was found to be downregulated in frontal and hippocampal regions in animal models of depression such as UCMS [122,123]. However, data in human are more inconsistent [124].…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

Haddjeri¹

2014

AAD

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Major Depressive Disorder (MDD) is a common illness worldwide with severe socioeconomic consequences. Several hypotheses have been formulated to explain the physiopathology of depression as well as the mechanism of action of antidepressants but two of them had attracted much attention. The dominant monoaminergic hypothesis of depression links the physiopathology of MDD to a deficiency on cerebral serotonin (5-HT) and/or Norepinephrine (NE) levels; however, the relatively new neurogenic and neurotrophic hypothesis raises the possibility of an impaired neuroplasticity and/or depletion of neurotrophic factors in specific networks resulting on their structural deformity and functional impairment. An enormous body of evidence reported particular neuroadaptations following chronic administration of antidepressant drugs. In this review, we describe major adaptive changes in pre-and post-synaptic 5-HT neurotransmission as well as alterations in gene transcription and neurotrophic factors in response to long-term treatment with conventional antidepressants, new putative ones or novel promising drug candidates, all acting via 5-HT system.

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Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study

Cited by 174 publications

References 59 publications

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

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