Stress Responses of Streptococci

Lemos, José A.; Tsakalidou, Effie; Papadimitriou, Konstantinos

doi:10.1007/978-0-387-92771-8_12

Cited by 4 publications

(4 citation statements)

References 273 publications

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“…Oxidative stress tolerance in streptococci is also driven by alkayl hydroperoxidase (AhpCF) and thiol peroxidase (Tpx) (Lemos et al, 2011 ; Papadimitriou et al, 2016 ). In S. mutans , peroxidase activity is mainly achieved through the AhpC-AhpF complex where AhpF (or Nox-1) acts as a dehydrogenase that reduces NADH and delivers electrons to AhpC.…”

Section: Bacterial Mechanisms To Cope With the Acid Stressmentioning

confidence: 99%

“…In S. mutans , peroxidase activity is mainly achieved through the AhpC-AhpF complex where AhpF (or Nox-1) acts as a dehydrogenase that reduces NADH and delivers electrons to AhpC. In addition, AhpC converts peroxidase into water or alchohol (Lemos et al, 2011 ). Transcriptional profile analysis displayed the upregulation of ahpCF upon transition from steady-state growth at pH 7 to steady-state growth at pH 5 in S. mutans (Baker et al, 2015a ).…”

Section: Bacterial Mechanisms To Cope With the Acid Stressmentioning

confidence: 99%

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Acid Stress Response Mechanisms of Group B Streptococci

Shabayek

Spellerberg

2017

Front. Cell. Infect. Microbiol.

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Group B streptococcus (GBS) is a leading cause of neonatal mortality and morbidity in the United States and Europe. It is part of the vaginal microbiota in up to 30% of pregnant women and can be passed on to the newborn through perinatal transmission. GBS has the ability to survive in multiple different host niches. The pathophysiology of this bacterium reveals an outstanding ability to withstand varying pH fluctuations of the surrounding environments inside the human host. GBS host pathogen interations include colonization of the acidic vaginal mucosa, invasion of the neutral human blood or amniotic fluid, breaching of the blood brain barrier as well as survival within the acidic phagolysosomal compartment of macrophages. However, investigations on GBS responses to acid stress are limited. Technologies, such as whole genome sequencing, genome-wide transcription and proteome mapping facilitate large scale identification of genes and proteins. Mechanisms enabling GBS to cope with acid stress have mainly been studied through these techniques and are summarized in the current review

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Section: Bacterial Mechanisms To Cope With the Acid Stressmentioning

confidence: 99%

Section: Bacterial Mechanisms To Cope With the Acid Stressmentioning

confidence: 99%

Acid Stress Response Mechanisms of Group B Streptococci

Shabayek

Spellerberg

2017

Front. Cell. Infect. Microbiol.

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“…It has been shown that S. agalactiae is able to survive in the mature phagolysosome for an extended period of time (12)(13)(14)(15). Thus, to cope with low pH, S. agalactiae possesses numerous defense mechanisms (16,17) that are regulated by two-component systems and transcriptional regulators (16,18,19). The oxidative stress response also contributes to acid adaptation (16) and occurs when ROS production prevails over the bacterium's ability to remove the threat (20).…”

mentioning

confidence: 99%

“…The oxidative stress response also contributes to acid adaptation (16) and occurs when ROS production prevails over the bacterium's ability to remove the threat (20). Oxidative stress can result in damage to nucleic acids, amino acids, cofactors of proteins, and lipids, and it is counteracted thanks to various mechanisms (17,(20)(21)(22)(23)(24)(25)(26)(27).…”

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confidence: 99%

The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response

et al. 2022

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Streptococcus agalactiae is a major cause of disease burden leading to morbidity and mortality in neonates worldwide. Deciphering its adaptation mechanisms is essential to understand how this bacterium manages to colonize its host. Here, we determined the regulon of the pleiotropic regulator CcpA in S. agalactiae . Our findings reveal that CcpA is not only involved in carbon catabolite repression, but is also important for acidic and oxidative stress resistance and survival in macrophages.

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Application of mild pulsed electric fields on starter culture accelerates yogurt fermentation

Chanos

Warncke

Ehrmann

et al. 2020

Eur Food Res Technol

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The goal of this work was to investigate the influence of pulsed electric fields (PEF) operational parameters on a mixture of Streptococcus thermophilus DIL 5218 and Lactobacillus delbrueckii subsp. bulgaricus DSMZ 20081 T with regards to the culture's acidification capability in reconstituted skim milk medium. We investigated the effects of field strength, pulse frequency and total number of pulses by use of design of experiments and a two-level full factorial design. The responses were the cell counts of the two microorganisms after PEF application, the pH lag phase λ pH , the maximum pH change rate µ max , the maximum pH change and the oxidation/reduction potential (ORP). The application of PEF on the mixed culture accelerated the acidification of milk by an average of 12 min in an approx. 160 min lasting control λ pH. In contrast the maximum pH change rate µ max and the maximum pH change decreased slightly in fermentations with PEF-treated cultures. Furthermore, a significantly faster decrease of the oxidation/reduction potential (ORP) already within the first 30 min and a lower final ORP was observed in milk fermented with PEF-treated culture. The total number of pulses applied was the most influencing factor in most of the responses measured. We hypothesized that the reason for the enhanced performance of the PEF-treated culture was a combination of an oxidative stress response of S. thermophilus DIL 5218 and an enhanced proteolytic phenotype in L. delbrueckii subsp. bulgaricus DSMZ 20081 T .

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Stress Responses of Streptococci

Cited by 4 publications

References 273 publications

Acid Stress Response Mechanisms of Group B Streptococci

Acid Stress Response Mechanisms of Group B Streptococci

The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response

Application of mild pulsed electric fields on starter culture accelerates yogurt fermentation

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