Stress Response in Candida albicans Induced by Boric Acid

Beach, Tyler; Hart, Benjamin E.; Larsen, Bryan

doi:10.9734/bjmmr/2016/25887

Cited by 4 publications

(1 citation statement)

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“…that boric acid may restore the persistence by inhibiting the several metabolic pathways including glycolysis, fermentation, and the mitochondrial activity (18). Boric acid was also shown to induce cell autofluorescence, decrease catalase activity and the cell size, and subsequently promote the programmed cell death (19).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of the boric acid-based maintenance therapy in preventing recurrent vulvovaginal candidiasis

Kalkan¹,

Yassa²,

Sandal³

et al. 2021

J Exp Clin Med

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Current gold-standard treatment of recurrent vulvovaginal candidiasis (RVVC) is mainly based on maintenance with fluconazole. Moderate to high recurrence rates at long-term use and secondary fluconazole resistance emerge as reasons to seek for new topical maintenance regimens. In this study, it is aimed to assess the efficacy and safety of boric acid-based treatment approach to treat clinical RVVC. In this retrospective study, patients who were diagnosed with RVVC received a treatment package for six months that consist of induction with boric acid vaginal suppositories 600 mg daily for 14 nights followed by maintenance for five nights starting with every fifth day of the menstrual cycles; a vaginal estriol-lactobacilli combination; and several rigorous life-style changes. The success was defined as the absence of symptomatic recurrence during the follow-up. Success rate at the first year was found to be 94.8% in a total of 173 patients. Mild, reversible side effects were observed in five patients (2.9%). Boric acid, along with a vaginal estriol-lactobacilli combination and lifestyle changes can be a safe and effective alternative in lieu of potent systemic antifungal drugs as a first-line treatment for the patients referred with RVVC.

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Section: Discussionmentioning

confidence: 99%

The efficacy of the boric acid-based maintenance therapy in preventing recurrent vulvovaginal candidiasis

Kalkan¹,

Yassa²,

Sandal³

et al. 2021

J Exp Clin Med

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Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans

2017

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Clinical use of boric acid as a topical antifungal in women who have failed standard antifungal therapy with azole drugs has been used sporadically for decades. Our previous in vitro work showing inhibition of Candida albicans growth was conducted on clinical isolates without antifungal drug susceptibility profiling. Here, we report that boric acid restricts growth of drug-resistant Candida albicans and inhibits hyphal growth and diminishes cell volume. The availability of over-the-counter organoboron compounds intended for use as oral nutritional supplements led us to determine if these also were inhibitory toward resistant Candida and show here that they also possess antifungal activity. Candida glabrata was also found to be inhibited by boric acid and organoboron compounds. Further development of organoboron compounds as topical therapeutics is of potential value.

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Antioxidant or pro-oxidant? The effects of boron compounds on Saccharomyces cerevisiae BY4741 strain

Yardımcı

Mollaoğlu

2020

Preparative Biochemistry & Biotechnology

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Stress Response in Candida albicans Induced by Boric Acid

Cited by 4 publications

References 0 publications

The efficacy of the boric acid-based maintenance therapy in preventing recurrent vulvovaginal candidiasis

The efficacy of the boric acid-based maintenance therapy in preventing recurrent vulvovaginal candidiasis

Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans

Antioxidant or pro-oxidant? The effects of boron compounds on Saccharomyces cerevisiae BY4741 strain

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