This paper represents an energy harvesting technique using a compliant mechanism driven Rosen type piezoelectric transformer from low frequency (3-10 Hz) reciprocal gripping motion. The finite element model of the compliant structure is synthesized using topology optimization implementing the density model and is coupled with a piezoceramic transformer to operate it by human hands. The mechanism can also be operated with the help of external mechanisms. As a case study, the proposed compliant mechanism is modelled considering acrylic plastic material. The mechanism can produce a maximum power of 62.7 μW for a 10 Hz gripping frequency while operating at its optimal conditions. The paper also discusses the resonance condition of the structure to check its marginal state. The harvested energy can be extracted across a load resistances attached at both primary and secondary side of the piezoelectric transformer.