Stress-related synaptic plasticity in the hypothalamus

Bains, Jaideep S.; Cusulin, Jaclyn I. Wamsteeker; Inoue, Wataru

doi:10.1038/nrn3881

Cited by 154 publications

(152 citation statements)

References 116 publications

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“…PVN and DMH, impaired in our murine HANS model, integrally controls autonomic, endocrine, and plays an important role in homeostatic maintenance for those functions. Recent advance in neuroscience has highlighted the importance of the PVN for stress-related synaptic plasticity in the hypothalamus45. The DMH and the suprachiasmatic nucleus (SCN) have their roles in circadian control of sleep, and in the brain’s circadian pacemaker, respectively.…”

Section: Discussionmentioning

confidence: 99%

Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin

Aratani

Fujita

Kuroiwa

et al. 2016

Sci Rep

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Vaccination is the most powerful way to prevent human beings from contracting infectious diseases including viruses. In the case of the human papillomavirus (HPV) vaccine, an unexpectedly novel disease entity, HPV vaccination associated neuro-immunopathetic syndrome (HANS), has been reported and remains to be carefully verified. To elucidate the mechanism of HANS, we applied a strategy similar to the active experimental autoimmune encephalitis (EAE) model - one of the most popular animal models used to induce maximum immunological change in the central nervous system. Surprisingly, mice vaccinated with pertussis toxin showed neurological phenotypes that include low responsiveness of the tail reflex and locomotive mobility. Pathological analyses revealed the damage to the hypothalamus and circumventricular regions around the third ventricle, and these regions contained apoptotic vascular endothelial cells. These data suggested that HPV-vaccinated donners that are susceptible to the HPV vaccine might develop HANS under certain environmental factors. These results will give us the new insight into the murine pathological model of HANS and help us to find a way to treat of patients suffering from HANS.

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Section: Discussionmentioning

confidence: 99%

Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin

Aratani

Fujita

Kuroiwa

et al. 2016

Sci Rep

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“…The eCB system is present throughout brain areas and neuronal circuits controlling anxiety 4,42 , fear 4,42 and stress 43 , from sensory circuits to output nuclei.…”

Section: Modulation Of Synaptic Processesmentioning

confidence: 99%

The endocannabinoid system in guarding against fear, anxiety and stress

et al. 2015

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The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB signalling seems to determine the value of fear-evoking stimuli and to tune appropriate behavioural responses, which are essential for the organism’s long-term viability, homeostasis and stress resilience; and dysregulation of eCB signalling can lead to psychiatric disorders. An understanding of the underlying neural cell populations and cellular processes enables the development of therapeutic strategies to mitigate behavioural maladaptation.

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“…Retrograde eCB signaling mediates multiple forms of synaptic plasticity, such as long-term depression (LTD) or depolarizationinduced suppression of inhibition/excitation (DSI/E). Recently, the effects of stress on synaptic transmission and plasticity have become a growing area of research (reviewed in (Joels et al, 2009;Popoli et al, 2011;Senst and Bains, 2014;Bains et al, 2015). As discussed, the CB1 receptor is expressed throughout the brain and is present on glutamate and GABA synapses in stress-sensitive circuits, such as the hypothalamus, mPFC, hippocampus, and amygdala.…”

Section: Functional Role Of Ecb Signaling In the Neurobiological Effementioning

confidence: 99%

Neurobiological Interactions Between Stress and the Endocannabinoid System

Morena

Patel

Bains

et al. 2015

Neuropsychopharmacol

487

496

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Stress affects a constellation of physiological systems in the body and evokes a rapid shift in many neurobehavioral processes. A growing body of work indicates that the endocannabinoid (eCB) system is an integral regulator of the stress response. In the current review, we discuss the evidence to date that demonstrates stress-induced regulation of eCB signaling and the consequential role changes in eCB signaling have with respect to many of the effects of stress. Across a wide array of stress paradigms, studies have generally shown that stress evokes bidirectional changes in the two eCB molecules, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), with stress exposure reducing AEA levels and increasing 2-AG levels. Additionally, in almost every brain region examined, exposure to chronic stress reliably causes a downregulation or loss of cannabinoid type 1 (CB1) receptors. With respect to the functional role of changes in eCB signaling during stress, studies have demonstrated that the decline in AEA appears to contribute to the manifestation of the stress response, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and increases in anxiety behavior, while the increased 2-AG signaling contributes to termination and adaptation of the HPA axis, as well as potentially contributing to changes in pain perception, memory and synaptic plasticity. More so, translational studies have shown that eCB signaling in humans regulates many of the same domains and appears to be a critical component of stress regulation, and impairments in this system may be involved in the vulnerability to stress-related psychiatric conditions, such as depression and posttraumatic stress disorder. Collectively, these data create a compelling argument that eCB signaling is an important regulatory system in the brain that largely functions to buffer against many of the effects of stress and that dynamic changes in this system contribute to different aspects of the stress response.

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Stress-related synaptic plasticity in the hypothalamus

Cited by 154 publications

References 116 publications

Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin

Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin

The endocannabinoid system in guarding against fear, anxiety and stress

Neurobiological Interactions Between Stress and the Endocannabinoid System

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