Stress-related immune suppression: Health implications

Glaser, Ronald; Rice, Julie; Sheridan, John F.; Fertel, Richard H.; Stout, Julie C.; Speicher, Carl E.; Pinsky, David J.; Kotur, Mark; Post, Alison E.; Beck, Melinda A.; Kiecolt‐Glaser, Janice K.

doi:10.1016/0889-1591(87)90002-x

Cited by 360 publications

(207 citation statements)

References 17 publications

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“…During examinations, students had higher antibody titers to these latent herpesviruses than during lower-stress periods, as weII as a poorer virus-specific memory T-cell response to EBV (11)(12)(13)(14). An increase in antibody titers to a latent herpesvirus reflects the memory immune response to an increase in the production of viral antigens after reactivation of the virus; thus, higher titers to a latent herpesvirus suggest that the cellular immune response is less competent in controlling herpesvirus latency.…”

Section: Introductionmentioning

confidence: 99%

Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1

1997

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Section: Introductionmentioning

confidence: 99%

Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1

1997

Self Cite

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“…This may add between-animal variation in responses to experimental procedures (Hau et al 2001, Morton & Hau 2002. Stress of longer duration induces immunosuppression and increased susceptibility to infectious diseases (Glaser et al 1987, Klein et al 1992). This suppression is mediated by adrenal glucocorticoid steroids (Whitten et al 1998), of which probably the main biologically active hormone in rats is corticosterone (Woodman 1997).…”

Section: Introductionmentioning

confidence: 99%

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Royo¹,

Bjork²,

Carlsson³

et al. 2004

Journal of Endocrinology

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Jugular catheters were inserted in nine male rats under general isofluorane anesthesia and the catheters were connected to a commercially available computerized blood sampling device (Accusampler). Blood samples (150 µl) were collected every 4 h during the first 24 h after surgery and every 12 h during the following 72 h until 94 h after surgery, when the animals were killed. All fecal pellets were collected at blood sampling. Serum corticosterone and fecal concentrations of immunoreactive corticosterone metabolites and immunoglobulin A (IgA) were quantified by ELISAs. In blood, high corticosterone concentrations (.200 ng/ml) were recorded in the first samples obtained after surgery, but the concentrations decreased steadily during the day and became cyclical, showing a diurnal variation with high levels during evenings and low levels in the mornings. The automatic blood sampling itself did not result in recordable increases in serum corticosterone concentrations. The time delay between the presence of elevated corticosterone levels in blood and in feces was approximately 12 h. Fecal immunoreactive corticosterone metabolite levels remained elevated during the 94 h study period after surgery. The fecal concentrations of IgA showed substantial between-animal variation and decreased non-significantly after the surgery. Like serum corticosterone, fecal IgA showed a diurnal variation in amounts excreted, in this case with high values in the morning and low values in the evening. The concentrations of fecal corticosterone and IgA were negatively correlated in samples obtained before surgery but no correlation existed after surgery. This indicates that fecal immunoreactive corticosterone metabolites, but not IgA, constitute a good marker of acute stress. For immunoreactive corticosterone metabolites as well as for IgA, the concentration in feces correlated well with total excretion, making single fecal samplings usable as a measure of total secretion.

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“…Numerous studies have shown that psychological stress can lead to decreased immune response (e.g. [5]). Stress also lowers the number of cytotoxic lymphocytes called "natural killer cells" that protect the body not only against infectious diseases but also play an important role in the rejection of tumors.…”

Section: Introductionmentioning

confidence: 99%

Measuring Emotional Wellbeing with a Non-intrusive Bed Sensor

Vloed

Berentsen

2009

Human-Computer Interaction – INTERACT 2009

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Abstract. We examine the possibility of using non-intrusive bed sensor measures to ascertain the emotional wellness of an individual. To this end we did a convergent validation study to determine whether heart rate and respiration measures provided by the bed sensor correlate with self reports through questionnaires. The results show that negative affect and worry tension positively correlate with nocturnal respiration.

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Stress-related immune suppression: Health implications

Cited by 360 publications

References 17 publications

Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1

Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1

Impact of chronic catheterization and automated blood sampling (Accusampler) on serum corticosterone and fecal immunoreactive corticosterone metabolites and immunoglobulin A in male rats

Measuring Emotional Wellbeing with a Non-intrusive Bed Sensor

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