Stress percolation criticality of glass to fluid transition in active cell layers

Monfared, Siavash; Ravichandran, Guruswami; Andrade, José E.; Doostmohammadi, Amin

doi:10.48550/arxiv.2210.08112

Cited by 2 publications

(3 citation statements)

References 62 publications

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“…This difference between the previous study and our study may be due to the density-dependent/ independent nature of the transition or the absence/presence of deformability of cells. The percolation found in the present study also differs from those related to the rigidity transition, such as densitydependent percolation in embryogenesis (10) or stress field percolation around the solid-fluid transition in the epithelial monolayer (40). The defect percolation occurs at defect ratio = 0.5 (Fig.…”

Section: Discussioncontrasting

confidence: 60%

Cell deformability drives fluid-to-fluid phase transition in active cell monolayers

Saito,

Ishihara

2024

Sci. Adv.

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Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for tissue homeostasis and stable developmental processes. However, large-scale simulations of deformable cells have been restricted to those of polygonal-shaped cells, limiting our understanding of populations of arbitrarily deformable cells, such as mesenchymal, amoeboid cells, and nonconfluent epithelial cells. Here, we present an efficient approach for simulating large populations of nonpolygonally deformable cells with considerably higher computational efficiency than existing methods. Using the method, we demonstrate that the densely packed active cell population interacting via excluded volume interactions exhibits a fluid-to-fluid transition. An experimentally measurable index of topological defects, defined using the number of neighboring cells, is also proposed to characterize this transition. This study provides a flexible approach to tissue-scale cell population and a broader perspective on the biological fluid phases.

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Section: Discussioncontrasting

confidence: 60%

Cell deformability drives fluid-to-fluid phase transition in active cell monolayers

Saito,

Ishihara

2024

Sci. Adv.

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“…From a more theoretical point of view, this provides an example of pulsating active matter, which has been recently explored via particle-based simulations with oscillating radii and continuum theory [53]. Systematically comparing predictions of our findings to different implementations of tissues, such as particle-based models [53] or phase-field models [54], with distinct rheological properties would be an interesting next step.…”

Section: Discussionmentioning

confidence: 88%

“…tissues, such as particle-based models [53] or phase-field models [54], with distinct rheological properties would be an interesting next step.…”

Section: Discussionmentioning

confidence: 99%

Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers

Boocock¹,

Hirashima

Hannezo³

2023

Preprint

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Living tissues are characterized by an intrinsically mechanochemical interplay of active physical forces and complex biochemical signalling pathways. Either feature alone can give rise to complex emergent phenomena, for example mechanically driven glassy dynamics and rigidity transitions, or chemically driven reaction-diffusion instabilities. An important question is how to quantitatively assess the contribution of these different cues to the large-scale dynamics of biological mate- rials. We address this in MDCK monolayers, considering both mechanochemical feedbacks between ERK signalling activity and cellular density as well as a mechanically active tissue rheology via a self-propelled vertex model. We show that the relative strength of active migration forces to mechanochemical couplings controls a transition from uniform active glass to periodic spatiotemporal waves. We parameterize the model from published experimental datasets on MDCK monolayers, and use it to make new predictions on the correlation functions of cellular dynamics and the dynamics of topological defects associated with the oscillatory phase of cells. Interestingly, MDCK monolayers are best described by an intermediary parameter region in which both mechanochemical couplings and noisy active propulsion have a strong influence on the dynamics. Finally, we study how tissue rheology and ERK waves feedback on one another, and uncover a mechanism via which tissue fluidity can be controlled by mechanochemical waves both at the local and global levels.

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Stress percolation criticality of glass to fluid transition in active cell layers

Cited by 2 publications

References 62 publications

Cell deformability drives fluid-to-fluid phase transition in active cell monolayers

Cell deformability drives fluid-to-fluid phase transition in active cell monolayers

Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers

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