Stress Pathways Induced by Volatile Anesthetics and Failure of Preconditioning in a Mitochondrial Complex I Mutant
Zachariah P. G. Olufs,
David A. Wassarman,
Misha Perouansky
Abstract:Background
Carriers of mutations in the mitochondrial electron transport chain (mETC) are at increased risk of anesthetic-induced neurotoxicity. To investigate the neurotoxicity mechanism and to test preconditioning as a protective strategy, we used a Drosophila melanogaster model of Leigh syndrome. Model flies carried a mutation in ND23 (ND2360114) that encodes an mETC Complex I subunit. We investigated why ND2360114 mutants become susceptible to lethal, oxygen-modulated neurotoxicity within… Show more
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