Stress-modulated collagen fiber remodeling in a human carotid bifurcation

Hariton, I.; deBotton, Gal; Gasser, Thomas C.; Holzapfel, Gerhard

doi:10.1016/j.jtbi.2007.05.037

Cited by 51 publications

(51 citation statements)

References 40 publications

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“…The discrepancy at high stretch levels can be attributable to the action of the complexly oriented collagen fibers. This effect has been also reported by Hariton et al [50]. The assumption of homogeneous mechanical properties along the whole arch is clearly a limitation of the present analysis.…”

Section: Aortic Archsupporting

confidence: 66%

Mechanical Characterization of the Human Aorta: Experiments, Modeling and Simulation

García‐Herrera

Celentano

Cruchaga

et al. 2016

Computational Modeling, Optimization and Manufacturing Simulation of Advanced Engineering Materials

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This chapter presents an overview of recent works aimed at characterizing the mechanical behaviour of the human aorta via experiments, modeling and simulation. The application of these techniques are in particular detailed in the analysis of the following cases: ascending aorta, aortic arch and thoracic descending aorta under in-vitro and in-vivo conditions. The experimental procedure encompasses uniaxial tension and pressurization tests on healthy and pathological tissues of different ages. The tensile measurements are used to calibrate the material parameters of isotropic or anisotropic quasi-static elastic constitutive models which are intended to predict the material response in a wide deformation range. Although this task is usually carried out analytically, numerical simulations (using a discretized formulation defined in the context of the finite element method) are also performed for problems in which more complex geometry, boundary conditions and loads are considered. Overall, the reported material characterization was found to provide a realistic description of the mechanical behaviour of the aorta subjected to various deformation and stress scenarios. Finally, the implication of these studies is the possibility to predict the mechanical response of the human aorta under generalized loading states like those that can occur in physiological conditions and/or in medical device applications.

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Section: Aortic Archsupporting

confidence: 66%

Mechanical Characterization of the Human Aorta: Experiments, Modeling and Simulation

García‐Herrera

Celentano

Cruchaga

et al. 2016

Computational Modeling, Optimization and Manufacturing Simulation of Advanced Engineering Materials

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“…Computational models of collagen remodelling assumed that either the principal strains (Boerboom et al 2003;Driessen et al 2004Driessen et al , 2008 or stresses (Baek et al 2006;Hariton et al 2007) govern the orientation of collagen fibres. With regard to AAA, marked increase of anisotropy was found in the diseased tissue (Vande Geest et al 2006), suggesting structural changes in aneurysm formation.…”

Section: Discussionmentioning

confidence: 99%

“…During the past decades, it has been shown that theoretical modelling of vascular growth and remodelling (G&R) can sharpen our understanding of roles of mechanical stimuli on such adaptations by testing multiple hypotheses based on the accumulated information from experimental studies in vascular pathophysiology and various clinical observations ). Recently, these theoretical models have been incorporated within the finite element method (FEM) framework by many researchers (Watton et al 2004;Menzel 2005;Baek et al 2006;Hariton et al 2007; Holzapfel 2007, 2009;Kuhl et al 2007;Figueroa et al 2009;Watton and Hill 2009), with results showing great potential for computational G&R simulations to become essential in patient-specific risk assessment of vascular diseases and their treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Humphrey and coworkers presented FEM models of stress-mediated G&R using a constrained mixture approach and modelled intracranial aneurysms (Baek et al 2005;Baek et al 2006;Figueroa et al 2009). Hariton et al (2007) studied the stress-driven collagen fibres remodelling in a human carotid bifurcation. On the other hand, strain-mediated models of vascular adaptation have also been developed and implemented to model cerebral and aortic aneurysms (Watton et al 2004;Holzapfel 2007, 2009;Watton and Hill 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A finite element model of stress-mediated vascular adaptation: application to abdominal aortic aneurysms

Zeinali‐Davarani

Sheidaei

Baek

2011

Computer Methods in Biomechanics and Biomedical Engineering

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Despite rapid expansion of our knowledge of vascular adaptation, developing patient-specific models of diseased arteries is still an open problem. In this study, we extend existing finite element models of stress-mediated growth and remodelling of arteries to incorporate a medical image-based geometry of a healthy aorta and, then, simulate abdominal aortic aneurysm. Degradation of elastin initiates a local dilatation of the aorta while stress-mediated turnover of collagen and smooth muscle compensates the loss of elastin. Stress distributions and expansion rates during the aneurysm growth are studied for multiple spatial distribution functions of elastin degradation and kinetic parameters. Temporal variations of the degradation function are also investigated with either direct time-dependent degradation or stretch-induced degradation as possible biochemical and biomechanical mechanisms for elastin degradation. The results show that this computational model has the capability to capture the complexities of aneurysm progression due to variations of geometry, extent of damage and stress-mediated turnover as a step towards patient-specific modelling.

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“…The advantages of using collagen products in medicine are its very low antigenicity, excellent histocompatibility, ease of association with other biologically active species such as glycose-aminoglycans, and its polyelectrolytic behavior. The reconstitution of collagen from solution into native fibers is also of interest because of its regenerative applications (Archer and Ralph, 2010;Hariton et al, 2007). For example, the fibroin produced by the silk worms (Bombix Mori), respectively the dragline produces by a kind of spider (Nephila Clavipes) are two examples of fibroid polymer which pose intrinsic resistance, elasticity and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%