Stress lowers the threshold dose at which bisphenol A disrupts blastocyst implantation, in conjunction with decreased uterine closure and e-cadherin

Borman, Evan D.; Foster, Warren G.; Greenacre, Matthew K.E.; Muir, Carlyn; deCatanzaro, Denys

doi:10.1016/j.cbi.2015.05.012

Cited by 24 publications

(19 citation statements)

References 69 publications

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“…Although the majority of studies indicate that BPA alters implantation, two experimental studies report no effect of low dose (58) or a relatively high dose (122 mg/kg/day) (59) of BPA on the number of implantation sites. The reasons for these discordant results are unclear, but it may be that the effects of BPA on implantation are ablated at high doses.…”

Section: Resultsmentioning

confidence: 99%

Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Ziv‐Gal

Flaws

2016

Fertility and Sterility

200

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We summarized the scientific literature published from 2007 to 2016 on the potential effects of bisphenol A (BPA) on female fertility. We focused on overall fertility outcomes (e.g., ability to become pregnant, number of offspring), organs that are important for female reproduction (i.e., oviduct, uterus, ovary, hypothalamus, and pituitary), and reproductive related processes (i.e., estrous cyclicity, implantation, and hormonal secretion). The reviewed literature indicates that BPA may be associated with infertility in women. Potential explanations for this association can be generated from experimental studies. Specifically, BPA may alter overall female reproductive capacity by affecting the morphology and function of the oviduct, uterus, ovary, and hypothalamus-pituitary-ovarian axis in animal models. Additionally, BPA may disrupt estrous cyclicity and implantation. Nevertheless, further studies are needed to better understand the exact mechanisms of action and to detect potential reproductive toxicity at earlier stages.

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Section: Resultsmentioning

confidence: 99%

Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Ziv‐Gal

Flaws

2016

Fertility and Sterility

200

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“…BPA and OP are among the most disruptive EDs and are widely used as plasticizers in consumer products. Several studies showed that high-dose BPA or OP treatment can result in a lowering of implantation rates in rats and mice [33,45,46]. Moreover, high exposure to BPA has been associated with miscarriage in human [47].…”

Section: Discussionmentioning

confidence: 99%

Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Tran

Jung

Ahn

et al. 2018

IJERPH

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Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for the embryo implantation process. Exposure to endocrine-disrupting chemicals (EDs) during early gestation results in disruption of intrauterine implantation and uterine reception, leading to implantation failure. In this study, ovarian estrogen (E2), bisphenol A (BPA), or 4-tert-octylphenol (OP), with or without ICI 182,780 (ICI) were injected subcutaneously from gestation day 1 to gestation day 3 post-coitus. The expression levels of the calcium transport genes were assessed in maternal uteri and implantation sites. The number of implantation sites was significantly low in the OP group, and implantation sites were absent in the E2, ICI and EDs + ICI groups. There were different calcium transient transport channel expression levels in uterus and implantation site samples. The levels of TRPV5 and TRPV6 gene expression were significantly increased by EDs with/without ICI treatment in utero. Meanwhile, TRPV5 and TRPV6 gene expression were significantly lower in implantation sites samples. NCX1 and PMCA1 mRNA levels were significantly decreased by OP and BPA in the implantation site samples. Compared to vehicle treatment in the uterus, both the MUC1 mRNA and protein levels were markedly high in all but the BPA group. Taken together, these results suggest that both BPA and OP can impair embryo implantation through alteration of calcium transport gene expressions and by affecting uterine receptivity.

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“…Failure of embryonic development to mouse blastocyst stage has been demonstrated after exposure of females to BPA (Xiao et al 2011). Disorder of implantation of mouse blastocysts was also demonstrated by Borman et al (2015).…”

Section: Influences Of Bpa On Reproduction Of Femalesmentioning

confidence: 99%

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2016

Czech J. Anim. Sci.

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A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.

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Stress lowers the threshold dose at which bisphenol A disrupts blastocyst implantation, in conjunction with decreased uterine closure and e-cadherin

Cited by 24 publications

References 69 publications

Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

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