Stress-like reaction ofDrosophila to adverse environmental factors

Rauschenbach, I. Yu.; Lukashina, N. S.; Maksimovsky, L. F.; Korochkin, L. I.

doi:10.1007/bf00691837

Cited by 59 publications

(31 citation statements)

References 38 publications

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“…Viability analysis under heat stress was designed as follows: 5 flies were placed in a vial with standard (Rauschenbach et al, 1987) medium (18e29 vials in each group under study). Before and after the experiments the flies were kept at 25 C. To determine viability under heat stress the vials with flies were transferred from 25 C to 38 C for 3.5 h. After which they were returned to 25 C, and 24 h after live flies were counted and survival rates were calculated as a percent of survivors in each vial.…”

Section: Viability Analysismentioning

confidence: 99%

“…20E stimulate vitellogenin (Vg) biosynthesis in the fat body and then Vg is subsequently taken up from hemolymph by ovaries. It is also shown that in insects, including Drosophila, JH is a part of neuroendocrine stress response (Rauschenbach et al, 1987(Rauschenbach et al, , 1995Cymborowski, 1991) and plays a key role in insect adaptation to stressors (review: Gruntenko and Rauschenbach, 2008). Therefore, the strict regulation of JH titer in insect body is crucial throughout their life.…”

Section: Introductionmentioning

confidence: 97%

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Altered juvenile hormone metabolism, reproduction and stress response in Drosophila adults with genetic ablation of the corpus allatum cells

Грунтенко

Wen

Karpova

et al. 2010

Insect Biochemistry and Molecular Biology

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Section: Viability Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Altered juvenile hormone metabolism, reproduction and stress response in Drosophila adults with genetic ablation of the corpus allatum cells

Грунтенко

Wen

Karpova

et al. 2010

Insect Biochemistry and Molecular Biology

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“…Cultures were raised on standard medium (Rauschenbach et al, 1987) at 25°C at a density of 20 larvae/7 ml of medium, and adults were synchronized at eclosion.…”

Section: Maintenance Of Stocksmentioning

confidence: 99%

Effects of octopamine on reproduction, juvenile hormone metabolism, dopamine, and 20‐hydroxyecdysone contents in Drosophila

Грунтенко

Karpova

Alekseev

et al. 2007

Arch Insect Biochem Physiol

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The effect of an experimentally increased octopamine content (feeding flies with OA) on the levels of juvenile hormone (JH) degradation, dopamine (DA), and 20-hydroxyecdysone (20E) contents, oogenesis, and fecundity of wild type Drosophila flies has been studied. OA feeding of the flies was found to (1) cause a considerable decrease in JH degradation in females, but not males, of D. melanogaster and D. virilis; (2) have no effect on DA content in D. melanogaster and D. virilis; (3) increase 20E contents in D. virilis females; (4) decrease to a large extent the number of vitellogenic (stages 8-10) and mature (stage 14) oocytes in D. virilis; and (5) decrease the fecundity of D. melanogaster and D. virilis. A possible mechanism of action of OA as a neurohormone on the reproductive function of Drosophila is discussed.

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“…In insects, the components of such stress reactions include juvenile hormone (JH) and 20-hydroxyecdysone (20E), which play a gonadotropic role in adults, and the biogenic amines dopamine (DA), serotonin and octopamine (OA), which function as neurotransmitters, neuromodulators and neurohormones (Orchard et al, 1981;Davenport and Evans, 1984;Rauschenbach et al, 1987;Woodring et al, 1988;Cymborowski, 1991;Hirashima and Eto, 1993;Rauschenbach et al, 1993;Rauschenbach et al, 1995a; RESEARCH ARTICLE Rauschenbach et al, 2004;Neckameyer and Weinstein, 2005;Andersen et al, 2006;Lalouette et al, 2007;Roesijadi et al, 2007;Gruntenko and Rauschenbach, 2008).…”

Section: Introductionmentioning

confidence: 99%

Disruption of insulin signalling affects the neuroendocrine stress reaction in Drosophila females

Rauschenbach

Karpova

Adonyeva

et al. 2014

Journal of Experimental Biology

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Juvenile hormone (JH) and dopamine are involved in the stress response in insects. The insulin/insulin-like growth factor signalling pathway has also recently been found to be involved in the regulation of various processes, including stress tolerance. However, the relationships between the JH, dopamine and insulin signalling pathways remain unclear. Here, we study the role of insulin signalling in the regulation of JH and dopamine metabolism under normal and heat stress conditions in Drosophila melanogaster females. We show that suppression of the insulin-like receptor (InR) in the corpus allatum, a specialised endocrine gland that synthesises JH, causes an increase in dopamine level and JH-hydrolysing activity and alters the activities of enzymes that produce as well as those that degrade dopamine [alkaline phosphatase (ALP), tyrosine hydroxylase (TH) and dopamine-dependent arylalkylamine N-acetyltransferase (DAT)]. We also found that InR suppression in the corpus allatum modulates dopamine, ALP, TH and JH-hydrolysing activity in response to heat stress and that it decreases the fecundity of the flies. JH application restores dopamine metabolism and fecundity in females with decreased InR expression in the corpus allatum. Our data provide evidence that the insulin/insulin-like growth factor signalling pathway regulates dopamine metabolism in females of D. melanogaster via the system of JH metabolism and that it affects the development of the neuroendocrine stress reaction and interacts with JH in the control of reproduction in this species.

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Stress-like reaction ofDrosophila to adverse environmental factors

Cited by 59 publications

References 38 publications

Altered juvenile hormone metabolism, reproduction and stress response in Drosophila adults with genetic ablation of the corpus allatum cells

Altered juvenile hormone metabolism, reproduction and stress response in Drosophila adults with genetic ablation of the corpus allatum cells

Effects of octopamine on reproduction, juvenile hormone metabolism, dopamine, and 20‐hydroxyecdysone contents in Drosophila

Disruption of insulin signalling affects the neuroendocrine stress reaction in Drosophila females

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