Stress, inflammation and endometriosis: are patients stuck between a rock and a hard place?

Tóth, Bettina

doi:10.1007/s00109-010-0595-4

Cited by 27 publications

(17 citation statements)

References 13 publications

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“…In addition, we also observed high stress indices among these women. 14,22,23 In this study, we observed 62.2% of women with stress, and psychologic stress was predominant in 41.5% of cases. A number of studies approach the binomy of pain symptoms with endometriosis.…”

Section: Discussionsupporting

confidence: 50%

“…Studies approaching psychological perspective of endometriosis deal with issues such as patients’ poor quality of life, 10,14,16-18 including harms in interpersonal and affective relationships; 6,16 difficulties in sexuality; 9,19 professional losses; 10,11 depression and anxiety; 3,7,20 suffering facing the recognition of healing difficulties; 21 ways for facing the disease; 4 constant presence of pain and stress; 4,5,22,23 importance of therapy and group support; 3,5,12-14 and other complementary therapies in which the objetive is to reduce pain and anxiety, such as acunputure and relaxing techniques, 24,25 exercises 26 and changes in eating habits. 1 …”

Section: Introductionmentioning

confidence: 99%

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Patients with endometriosis using positive coping strategies have less depression, stress and pelvic pain

Donatti

Ramos

Andres

et al. 2017

Einstein (São Paulo)

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Objective To determine the correlations between coping strategies, depression, stress levels and pain perception in patients with endometriosis.Methods This prospective and exploratory study included 171 women undergoing treatment for endometriosis between April and August 2014. The questionnaires used were Brief COPE, Beck Depression Inventory, Lipp’s Stress Symptom Inventory for Adults and Visual Analogue Scale. Clinical data were collected from electronic medical records.Results Patients with endometriosis who used positive coping strategies had better adaptation to stress (p<0.004) and less depression (p<0.004). The presence and intensity of depression, stress and acyclic pelvic pain were directly associated (p<0.05). The intensity of dysmenorrhea was associated with the degree of depression (p<0.001), whereas acyclic pelvic pain was associated with the degree of depression (p<0.001), stress level (p<0.001) and stress type (p<0.001).Conclusion We found a positive association between coping, depression levels, type and levels of stress and pain intensity in patients with endometriosis. The use of maladaptive coping strategies focused on emotion is correlated with increase in depression and stress.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Patients with endometriosis using positive coping strategies have less depression, stress and pelvic pain

Donatti

Ramos

Andres

et al. 2017

Einstein (São Paulo)

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“…Lastly, oxidative stress, exceeding the neutralizing capacity of the natural antioxidant mechanisms, may also trigger endometriosis [23]. It is known that the stress response causes the release of many hormones such as corticotrophin-releasing hormone, aggravating the inflammatory response in peritoneal lymphocytes [24]. …”

Section: Discussionmentioning

confidence: 99%

Can Platelet Indices Be New Biomarkers for Severe Endometriosis?

Avcıoğlu

Altınkaya

Küçük

et al. 2014

ISRN Obstetrics and Gynecology

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Objective. The aim of this study was to investigate whether platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) would be useful as noninvasive biomarkers for determining the severity of endometriosis. Methods. A retrospective review of the medical charts of 164 patients diagnosed with endometriosis and who were operated on between 2001 and 2013 was performed. The stage of endometriosis was determined according to revised American Society for Reproductive Medicine criteria. Results. In patients with advanced endometriosis (Stages 3-4), PLT, PCT levels were found to be significantly higher and MPV, PDW values to be significantly lower when compared to initial endometriosis (Stages 1-2). In addition, there was a significant positive correlation between PLT (r: 0.800, P: 0.001) and PCT (r: 0.727, P: 0.002) and the inflammatory marker white blood cell count (WBC). Conclusion. Our finding may not sufficient for employing platelet indices solely in this differential diagnosis, but our finding could provide a suggestion for clinical physicians so that attention is paid to the value of platelet indices and that these may be taken into account when making decisions about the initial or advanced stages of endometriosis.

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“…Endometriosis can be commonly misdiagnosed as irritable bowel syndrome (IBS)(19) due to overlap in common symptoms and perhaps mechanisms of disease progression involving aberrant activation of inflammatory cascades. The causes of endometriosis onset are unknown; however, a relationship between stress, hypothalamic pituitary adrenal axis (HPA) dysregulation, and endometriosis severity has been documented by others and our own work in the rat model of endometriosis (20–23). Strong evidence (from both human and animal studies) suggest that abnormal functioning of the HPA axis, release of CRH and/or the inflammatory response system disrupts feedback of both neuroendocrine and immune systems contributing to the development of the disease (24,25).…”

Section: Introductionmentioning

confidence: 77%

Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis

Torres-Reverón

Rivera-Lopez

Flores

et al. 2018

Preprint

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Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding an effective and long-term treatment for endometriosis still remains one of the most significant challenges in the field. Corticotropin releasing hormone (CRH) is one of the main signaling peptides within the hypothalamic pituitary adrenal (HPA) axis released in response to stress. CRH can affect nervous and visceral tissues such as the uterus and gut via activation of two types of CRH receptors: CRHR1 and CRHR2. Our aim was to determine if blocking CRHR1 with antalarmin will reduce endometriosis progression. First, we induced endometriosis in female rats by suturing uterine horn tissue next to the intestinal mesentery and allowed to progress for 7 days. We determined that after 7 days, there was a significant increase in CRHR1 within endometriotic vesicles as compared to normal uterus. A second group of rats received endometriosis but also antalarmin (20 mg/kg, i.p.) during the first 7 days after surgery. As separate group of sham surgery rats served as controls. Endometriosis was allowed to progress until 60 days after surgery. At time of sacrifice, rats were tested for anxiety behaviors and endometriotic vesicles, and uterus were collected. Rats with endometriosis that received antalarmin significantly reduced the size (67% decrease) and number (30% decrease) of endometriotic vesicles. Antalarmin also prevented the increase in CRH and CRHR1 within endometriotic vesicles but not of glucocorticoid receptor. Behaviorally, endometriosis increased anxiety in the zero-maze test but antalarmin did not modify it. Our data provides the first demonstration for the effective use on CRHR1 antagonist for the treatment of endometriosis with promising effects for long-term therapy of this debilitating disease.

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Stress, inflammation and endometriosis: are patients stuck between a rock and a hard place?

Cited by 27 publications

References 13 publications

Patients with endometriosis using positive coping strategies have less depression, stress and pelvic pain

Patients with endometriosis using positive coping strategies have less depression, stress and pelvic pain

Can Platelet Indices Be New Biomarkers for Severe Endometriosis?

Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis

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