Stress-inducible IL-6 is regulated by KLF7 in brown adipocytes

Effects of Health-Promoting Lifestyle on Late-Onset Depression in Older Adults: Mediating Effect of Meaning in Life and Interleukin-6 (IL-6)

“…43,44 Chronic mild stress and high-fat Diet, associated with IL-6 in the hippocampus and prefrontal cortex of rats, are further associated with depression-like behaviors, Tang proposed that stress-inducible IL-6, generated in brown adipocytes via beta-3 adrenergic receptor (ADRB3) signaling, is necessary in stress hyperglycemia as a kind of metabolic adaptation enabling "fight or flight" response, stress management and social support to some extent relieve stress response and down regulate IL-6 level. [45][46][47][48] Nutritional-balanced diets are beneficial to health maintenance for human being, one previous study showed that the soybean and fish oil mixture, more than the fish oil alone, could be a complementary therapy to achieve a cytokine balance in ulcerative colitis. Another study conducted in children with cancer suggested that 56% of children were undernourished with higher tumor necrosis factor-α (TNF-α) and IL-6 levels, and the cytokine responses during chemotherapy were related to nutritional status for the greatly decreased IL-6 level in the well-nourished group.…”