Stress-induced TDP-43 nuclear condensation causes splicing loss of function and STMN2 depletion

Huang, Wan-Ping; Ellis, Brittany C.S.; Hodgson, Rachel E.; Sanchez Avila, Anna; Kumar, Vedanth; Rayment, Jessica; Moll, Tobias; Shelkovnikova, Tatyana A.

doi:10.1016/j.celrep.2024.114421

Cell Reports

2024

DOI: 10.1016/j.celrep.2024.114421

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Stress-induced TDP-43 nuclear condensation causes splicing loss of function and STMN2 depletion

Wan-Ping Huang,

Brittany C.S. Ellis,

Rachel E. Hodgson

et al.

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2024

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Cited by 3 publications

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C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology

Hodgson,

Rayment,

Huang

et al. 2024

iScience

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C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology

Hodgson,

Rayment,

Huang

et al. 2024

iScience

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TDP-43 nuclear condensation and neurodegenerative proteinopathies

Vassallu,

Igaz

2024

Trends in Neurosciences

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TDP-43 in nuclear condensates: where, how, and why

Lang,

Hodgson,

Shelkovnikova

2024

Biochemical Society Transactions

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TDP-43 is an abundant and ubiquitously expressed nuclear protein that becomes dysfunctional in a spectrum of neurodegenerative diseases. TDP-43's ability to phase separate and form/enter biomolecular condensates of varying size and composition is critical for its functionality. Despite the high density of phase-separated assemblies in the nucleus and the nuclear abundance of TDP-43, our understanding of the condensate-TDP-43 relationship in this cellular compartment is only emerging. Recent studies have also suggested that misregulation of nuclear TDP-43 condensation is an early event in the neurodegenerative disease amyotrophic lateral sclerosis. This review aims to draw attention to the nuclear facet of functional and aberrant TDP-43 condensation. We will summarise the current knowledge on how TDP-43 containing nuclear condensates form and function and how their homeostasis is affected in disease.

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Stress-induced TDP-43 nuclear condensation causes splicing loss of function and STMN2 depletion

Cited by 3 publications

References 84 publications

C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology

C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology

TDP-43 nuclear condensation and neurodegenerative proteinopathies

TDP-43 in nuclear condensates: where, how, and why

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