Stress-Induced Sensitization of Insula Activation Predicts Alcohol Craving and Alcohol Use in Alcohol Use Disorder

Bach, Patrick; Zaiser, Judith; Zimmermann, Sina; Gessner, Tatjana; Hoffmann, Sabine; Gerhardt, Sarah; Berhe, Oksana; Bekier, Nina Kim; Abel, Martin; Radler, Philipp; Langejürgen, Jens; Tost, Heike; Lenz, Bernd; Vollstädt-Klein, Sabine; Stallkamp, Jan; Kirschbaum, Clemens; Kiefer, Falk

doi:10.1016/j.biopsych.2023.08.024

Cited by 7 publications

(1 citation statement)

References 61 publications

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“… Bach et al 39 published in Biological Psychiatry the original investigation on stress induced sensitization of insula activation predicts alcohol craving and alcohol use in alcohol use disorder. In this study, the effect of stress‐ and alcohol cue‐exposure on alcohol craving and the underlying neurocircuitry were determined.…”

Section: What Has the Recode Consortium Achieved In The First Funding...mentioning

confidence: 99%

The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives

Spanagel,

Bach,

Banaschewski

et al. 2024

Addiction Biology

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Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real‐life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug‐related behaviours and (iii) to provide non‐invasive mechanism‐based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug‐taking state to an addiction or resilience‐like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non‐invasive interventions (e.g., Just‐In‐Time‐Adaptive‐Interventions (JITAIs), various non‐invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.

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Section: What Has the Recode Consortium Achieved In The First Funding...mentioning

confidence: 99%

The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives

Spanagel,

Bach,

Banaschewski

et al. 2024

Addiction Biology

Self Cite

View full text Add to dashboard Cite

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Stress, Cues, and Craving: Does the Insula Hold the Key to Understanding Stress-Induced Drinking in Alcohol Use Disorder?

Schacht

2024

Biological Psychiatry

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Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking

Le,

Oba,

Couch

et al. 2024

Transl Psychiatry

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Stress-Induced Sensitization of Insula Activation Predicts Alcohol Craving and Alcohol Use in Alcohol Use Disorder

Cited by 7 publications

References 61 publications

The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives

The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives

Stress, Cues, and Craving: Does the Insula Hold the Key to Understanding Stress-Induced Drinking in Alcohol Use Disorder?

Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking

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