Stress induced risk-aversion is reverted by D2/D3 agonist in the rat

Morgado, Pedro; Marques, Fernanda; Ribeiro, Beatriz C.; Leite‐Almeida, Hugo; Pêgo, José M.; Rodrigues, Ana João; Dalla, Christina; Kokras, Nikolaos; Sousa, Nuno; Cerqueira, João José

doi:10.1016/j.euroneuro.2015.07.003

Cited by 23 publications

(12 citation statements)

References 45 publications

(68 reference statements)

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“…Whereas in the Honk et al study choice patterns were related to basal cortisol levels, which are a constitutive characteristic of individuals, Kandasamy and colleagues evaluated the impact of cortisol elevation, replicating in a more natural way the impact of chronic stress. Preliminary data from our laboratory demonstrate that a risk‐averse pattern of choice is induced by chronic stress in a rodent risk‐based decision‐making paradigm (Morgado et al, , ), in line with Kandasamy et al's observations.…”

Section: Stress and Risky Decision Makingsupporting

confidence: 84%

The impact of stress in decision making in the context of uncertainty

Morgado

Sousa

Cerqueira

2014

J of Neuroscience Research

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For a number of decades, different fields of knowledge, including psychology, economics, and neurosciences, have focused their research efforts on a better understanding of the decision-making process. Making decisions based on the probability of future events is routine in everyday life; it occurs whenever individuals select an option from several alternatives, each one associated with a specific value. Sometimes subjects decide knowing the precise outcomes of each option, but commonly they have to decide without knowing the consequences (because either ambiguity or risk is involved). Stress has a broad impact on animal behaviors, affects brain regions involved in decision-making processes, and, when maladaptive, is a trigger for neuropsychiatric disorders. This Mini-Review provides a comprehensive overview on how stress impacts decision-making processes, particularly under uncertain conditions. Understanding this can prove to be useful for intervention related to impairments to decision-making processes that present in several stress-triggered neuropsychiatric disorders.

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Section: Stress and Risky Decision Makingsupporting

confidence: 84%

The impact of stress in decision making in the context of uncertainty

Morgado

Sousa

Cerqueira

2014

J of Neuroscience Research

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“…Levy et al, 2010). These process are likely supported by dopamine action in those regions (Castrellon et al, 2019;Morgado et al, 2015;Soutschek et al, 2020). Although loss aversion and probability weighting seem to be reflected in the striatum and vmPFC like subjective value, they have unique representations in other parts of the brain.…”

Section: Risk and Uncertaintymentioning

confidence: 99%

Decision Neuroscience and Neuroeconomics: Recent Progress and Ongoing Challenges

Dennison¹,

Sazhin

Smith

2020

Preprint

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In the past decade, decision neuroscience and its subfield of neuroeconomics have developed many new insights in the study of decision making. This review provides a comprehensive update on how the field has advanced in this time. Although our initial review a decade ago outlined several theoretical, conceptual, methodological, empirical, and practical challenges, there has only been limited progress in resolving these challenges. We summarize significant trends in decision neuroscience through the lens of the challenges outlined for the field and review examples where the field has had significant, direct, and applicable impacts across psychology, neuroscience, and economics. We will first review progress in basic value processes involved in reward learning, explore-exploit decisions, risk and uncertainty, intertemporal choice, and valuation. Next, we assess the impacts of emotion, social rewards, and social context on decision making. Then, we follow up with how individual differences impact choice, and exciting developments in prediction and neuroforecasting of future decisions. Finally, we will consider overall progress in the field of decision neuroscience in reconciling past challenges, identifying new challenges, and recent exciting applications of this research.

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“…It has been frequently suggested that the anterior insula is relevant for higherlevel processing 42 and risk level, 43 as a consequence of its involvement in learning the negative value of loss-prediction cues. 44,45 Activation of the posterior insula has also been associated with lower risk levels, suggesting that different divisions of the insula play opposing roles during risk processing. In fact, evidence from a meta-analysis is consistent with the proposal that different divisions of the insula are characterized by dissociated connectivity profiles.…”

Section: Healthy Controls Ocdmentioning

confidence: 99%

Altered response to risky decisions and reward in patients with obsessive–compulsive disorder

Moreira

Macoveanu

Marques

et al. 2020

jpn

Self Cite

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Background: Patients with obsessive-compulsive disorder (OCD) employ ritualistic behaviours to reduce or even neutralize the anxiety provoked by their obsessions. The presence of excessive rumination and indecision has motivated the view of OCD as a disorder of decision-making. Most studies have focused on the "cold," cognitive aspects of decision-making. This study expands current understanding of OCD by characterizing the abnormalities associated with affective, or "hot" decision-making. Methods: We performed a functional MRI study in a sample of 34 patients with OCD and 33 sex-and age-matched healthy controls, during which participants made 2-choice gambles taking varying levels of risk. Results: During risky decisions, patients showed significantly reduced task-related activation in the posterior cingulum, lingual gyrus and anterior cingulate cortex. We identified significant group × risk interactions in the calcarine cortex, precuneus, amygdala and anterior cingulate cortex. During the outcome phase, patients with OCD showed stronger activation of the orbitofrontal cortex, anterior cingulate cortex and putamen in response to unexpected losses. Limitations: The group of patients not receiving medication was very small (n = 5), which precluded us from assessing the effect of medication on risk-taking behaviour in these patients. Conclusion: Obsessive-compulsive disorder is associated with abnormal brain activity patterns during risky decision-making in a set of brain regions that have been consistently implicated in the processing of reward prediction errors. Alterations in affective "hot" processes implicated in decision-making may contribute to increased indecisiveness and intolerance to uncertainty in patients with OCD.

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Stress induced risk-aversion is reverted by D2/D3 agonist in the rat

Cited by 23 publications

References 45 publications

The impact of stress in decision making in the context of uncertainty

The impact of stress in decision making in the context of uncertainty

Decision Neuroscience and Neuroeconomics: Recent Progress and Ongoing Challenges

Altered response to risky decisions and reward in patients with obsessive–compulsive disorder

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