Stress-induced rearrangment of the myocardium: Time course of structural changes in various types of stress

Evseeva, M. E.

doi:10.1007/bf02682031

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…Для развития такого подхода уже начинает появляться необходимая база данных по расшифровке молекулярных механизмов преждевременного сосудистого старения, которые создают новые возможности в разработке инновационных антивозрастных технологий. Полезным будет для изучения процессов сосудистого старения использование экспериментального моделирования, которое с успехом уже использовалось при изучении некоторых ФР [15]. Но пока возможности проведения ангиопротективных вмешательств антиэйджинговой направленности у молодых людей с учетом возможного ПО остаются совершенно не изученными, поэтому необходимы дальнейшие углубленные разработки в этом направлении, включая проспективные исследования.…”

Section: Discussionunclassified

Youth obesity paradox from the perspective of vascular stiffness, blood pressure and metabolic status

Evsevieva,

Sergeeva,

Rusidi

et al. 2024

Russ J Cardiol

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Aim. To assess functional parameters of the middle and inner arterial wall layers in relation to body mass index (BMI) in young people from the perspective of their vascular aging phenotype and sex.Material and methods. A total of 264 young people (93 boys) aged from 18 to 25 years (21,4±1,3) were examined. In three groups formed according to BMI, cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI), as well as the main parameters of hemodynamic and metabolic status were determined. Angiological screening aimed at assessing vascular stiffness (VS) and blood pressure (BP) in the vascular beds was performed using a VaSera VS-1500 system ("Fukuda Denshi", Japan). The subjects were divided into tertile CAVI groups based on sex to identify carriers of early, normal and favorable vascular aging phenotypes.Results. As body weight increases in young people, a tendency towards a CAVI decrease was revealed without significant changes in the ABI. In boys, CAVI-R decreased on average by 26,4% (p=0,000) and CAVI-L — by 25,9% (p=0,000). In girls, the decrease was less pronounced. But the latter showed a significant positive relationship between BMI and systolic BP, diastolic BP, low-density lipoproteins, triglycerides, atherogenicity coefficient, as well as a significant negative relationship with high-density lipoproteins. In young men, no significant relationship was found between BMI and any hemodynamic and metabolic parameters. More than half of the overweight boys and girls were carriers of favorable vascular aging phenotype, and among them, the majority noted problems with excess weight either in middle and high school or during student years. In addition, 12,0% of overweight boys and 26,3% of the same girls were characterized by early vascular aging. The vast majority of them were distinguished by excess body weight starting from early childhood.Conclusion. In young people aged 18 to 25 years (21,4±1,3), a VS decrease was revealed against the background of BMI increase. This phenomenon is more typical for carriers of recent obesity. The identified phenomenon, caused by an adaptive mechanism, may be called the youth obesity paradox and it should be taken into account when carrying out preventive measures among young people.

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Section: Discussionunclassified

Youth obesity paradox from the perspective of vascular stiffness, blood pressure and metabolic status

Evsevieva,

Sergeeva,

Rusidi

et al. 2024

Russ J Cardiol

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Stress and sudden death

Lathers

Schraeder

2006

Epilepsy & Behavior

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Cardiovascular Manifestations of Sedatives and Analgesics in the Critical Care Unit

Darrouj

Karma

Arora

2009

American Journal of Therapeutics

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There are numerous sedatives and analgesics used in critical care medicine today; these medications are used on critically ill patients, many of whom have heart disease, including coronary artery disease or congestive heart failure. The purpose of this review is to recognize the effects of these medications on the heart. Studies that evaluated the effects of sedatives and analgesics on normal individuals or on those with heart disease were reviewed. Current choices for sustained sedation in the critically ill include the benzodiazepines, morphine, propofol, and etomidate. Each of these medications has their particular advantages and disadvantages. Benzodiazepines provide the greatest amnesia and cardiovascular safety but they can cause significant hypotension in the hemodynamically unstable patient. Morphine provides analgesia and cardioprotective activity after ischemia, although the large observational study CRUSADE showed increased mortality rate in those patients with non-ST segment elevation myocardial infarction who received morphine. Propofol is the most easily titratable drug with cardioprotective features, but its use must be accompanied with great attention to possible development of propofol infusion syndrome, which is a deadly disease, especially in patients with head injury and those with septic shock receiving vasopressors. Etomidate has a rapid onset effect and short period of action with great hemodynamic stability even in patients with shock and hypovolemia, but the incidence of adrenal insufficiency during infusion, not bolus doses, may cause deterioration in the circulatory stability. In conclusion, the sedatives and analgesics mentioned here have characteristics that give them a cardiovascular safety profile useful in critically ill patients. However, use of these drugs on an individual basis is dependent on each agent's safety and efficacy.

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Stress-induced rearrangment of the myocardium: Time course of structural changes in various types of stress

Cited by 5 publications

References 2 publications

Youth obesity paradox from the perspective of vascular stiffness, blood pressure and metabolic status

Youth obesity paradox from the perspective of vascular stiffness, blood pressure and metabolic status

Stress and sudden death

Cardiovascular Manifestations of Sedatives and Analgesics in the Critical Care Unit

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