Stress-Induced Parasympathetic Control and Its Association With Inflammatory Reactivity

Woody, Alex; Figueroa, Wilson S.; Benencia, Fabián; Zoccola, Peggy M.

doi:10.1097/psy.0000000000000426

Cited by 29 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After adjusting for age and CAD risk factors, sympatho-vagally mediated HRV remained a significant predictor of CRP. A recent study of 30 young healthy women reported that low vagal tone indicated by reductions in vagally mediated HRV was associated with greater increase in TNF-α and IL-6 but not CRP in response to a speech stressor task ( Woody et al, 2017a ).…”

Section: Stress and The Immune Systemmentioning

confidence: 99%

“…Albeit mixed ( Owen and Steptoe, 2003 ; Lampert et al, 2008 ), the evidence seems to indicate that prefrontally modulated vagal activity, indicated by vagally mediated HRV is associated with serum levels of pro-inflammatory cytokines ( Sloan et al, 2007 ; von Känel et al, 2007 ; Weber et al, 2010 ; Woody et al, 2017a ), which according to the NISIM is due to lower prefrontal stress regulation capacity resulting in less cholinergic inhibition of inflammatory cytokine production, which in turn results in increased production of TNF-α and IL-6.…”

Section: Stress and The Immune Systemmentioning

confidence: 99%

“…Depression is another major confounder ( Kop et al, 2010 ; Felger and Lotrich, 2013 ), so the degree to which participants have been screened for depressive symptoms, or people with depression is included in the sample could affect the level of cytokines that are observed. One study included depressed people in their sample ( Lampert et al, 2008 ), and three studies did not screen for previous or current depression ( Sloan et al, 2007 ; von Känel et al, 2007 ; Woody et al, 2017a ). Five studies did not exclude smokers ( Owen and Steptoe, 2003 ; Sloan et al, 2007 ; von Känel et al, 2007 ; Lampert et al, 2008 ; Weber et al, 2010 ), and at least two studies included people with hypertension and diabetes ( Sloan et al, 2007 ; Lampert et al, 2008 ).…”

Section: Predictions and Conclusionmentioning

confidence: 99%

“…Activity in vagal fibers results in increased transmission of cholinergic ligands onto the cholinergic receptors on macrophages, mediated by the splenic nerve, subsequently reducing cytokine production ( Wang H. et al, 2003 ; Rosas-Ballina et al, 2008 ). Individuals with lower stress regulation capacity have an increased adrenergic stimulation of macrophages which increases production and release of cytokines ( Sloan et al, 2007 ; Woody et al, 2017a ) that trigger the nuclear factor kappa light chain enhancer of activated B cells (NFκB) pathway ( Sakurai et al, 2003 ; Feng et al, 2017 ) and cause an increase in reactive oxygen species ( Schulze-Osthoff et al, 1992 ; Behrens et al, 2008 ). Connecting psychological stress regulation to production of reactive oxygen species via this pathway from the modulatory activity of the CAN to cytokine induced NFκB activation is, to our knowledge, novel.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

2018

View full text Add to dashboard Cite

There is evidence that accumulated senescent cells drive age-related pathologies, but the antecedents to the cellular stressors that induce senescence remain poorly understood. Previous research suggests that there is a relationship between shorter telomere length, an antecedent to cellular senescence, and psychological stress. Existing models do not sufficiently account for the specific pathways from which psychological stress regulation is converted into production of reactive oxygen species. We propose the neuro-immuno-senescence integrative model (NISIM) suggesting how vagally mediated heart rate variability (HRV) might be related to cellular senescence. Prefrontally modulated, and vagally mediated cortical influences on the autonomic nervous system, expressed as HRV, affects the immune system by adrenergic stimulation and cholinergic inhibition of cytokine production in macrophages and neutrophils. Previous findings indicate that low HRV is associated with increased production of the pro-inflammatory cytokines IL-6 and TNF-α. IL-6 and TNF-α can activate the NFκB pathway, increasing production of reactive oxygen species that can cause DNA damage. Vagally mediated HRV has been related to an individual’s ability to regulate stress, and is lower in people with shorter telomeres. Based on these previous findings, the NISIM suggest that the main pathway from psychological stress to individual differences in oxidative telomere damage originates in the neuroanatomical components that modulate HRV, and culminates in the cytokine-induced activation of NFκB. Accumulated senescent cells in the brain is hypothesized to promote age-related neurodegenerative disease, and previous reports suggest an association between low HRV and onset of Alzheimer’s and Parkinson’s disease. Accumulating senescent cells in peripheral tissues secreting senescence-associated secretory phenotype factors can alter tissue structure and function which can induce cancer and promote tumor growth and metastasis in old age, and previous research suggested that ability to regulate psychological stress has a negative association with cancer onset. We therefore conclude that the NISIM can account for a large proportion of the individual differences in the psychological stress-related antecedents to cellular senescence, and suggest that it can be useful in providing a dynamic framework for understanding the pathways by which psychological stress induce pathologies in old age.

show abstract

Section: Stress and The Immune Systemmentioning

confidence: 99%

Section: Stress and The Immune Systemmentioning

confidence: 99%

Section: Predictions and Conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

2018

View full text Add to dashboard Cite

show abstract

“…We will limit this discussion to just a few representative studies. Using a stress-inducing paradigm (speech stressor), Woody et al (2017) detected greater reductions in HF-HRV in association with the proinflammatory cytokines, IL-6 and TNFα, but not C-reactive protein (CRP) [44] . Using data from a large study (MIDUS II), Cooper et al (2015) found LF-HRV to be inversely associated with CRP and IL-6 while HF-HRV was inversely associated with fibrinogen and CRP [45] .…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability Predicts Treatment Outcome in Major Depression

Hage¹,

Sinacore²,

Heilman³

et al. 2017

J Psychiatry Brain Sci.

View full text Add to dashboard Cite

Aims: Autonomic nervous system (ANS) dysregulation is associated with various symptoms of depressive disorder. The beat-to-beat pattern of heart rate (Heart Rate Variability) (HRV) provides a noninvasive portal to ANS function through the quantification of periodic heart rate patterns. In this study we quantified two components of HRV: Respiratory Sinus Arrhythmia (RSA), and Low Frequency HRV (LF-HRV). Both of these components have been extensively reported in studies of depression and have been at least partially associated with reduction in vagal nerve tone. We quantified RSA and LF-HRV in patients with Major Depressive Disorder (MDD) as measures of ANS regulation seeking to establish the utility of components of HRV as potential diagnostic and prognostic biomarkers for treatment outcome. Methods: Sixty-six MDD patients were enrolled. In two separate and consecutively run studies they received either Escitalopram or Quetiapine fumarate ER over 12 weeks. Forty-one patients completed the studies. RSA and LF-HRV were assessed at pretreatment and end of study. Thirty-six healthy subjects served as controls. RSA and LF-HRV were quantified using an algorithm that incorporates time and frequency domains to address the non-stationarity of the beat-to-beat heart rate pattern. Results: No significant differences in baseline RSA or LF-HRV were found between MDD and healthy controls. However, baseline RSA and LF-HRV were significantly higher in treatment responders (lnRSA = http://jpbs.qingres.com

show abstract

Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial

González-Santos

Postigo-Martín

Gallart-Aragón

et al. 2021

Research in Nursing & Health

View full text Add to dashboard Cite

A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). This superiority randomized controlled trial aims to examine the feasibility and efficacy of an 8‐week multimodal intervention (ATENTO) based on moderate‐vigorous intensity and individualized TE (aerobic and strength exercises) and VAT (myofascial and breathing exercises), on neurotoxicity prevention in women with BC before starting adjuvant chemotherapy (ATENTO‐B) versus throughout adjuvant chemotherapy (ATENTO‐T). A sample of 56 women newly diagnosed with BC, as calculated with a power of 85%, will be randomly allocated into these two groups. This study could provide an impetus for the introduction of early multimodal intervention methods to prevent neurotoxicity and consequently avoid the QoL deterioration that BC patients presently suffer throughout their treatments.

show abstract

Stress-Induced Parasympathetic Control and Its Association With Inflammatory Reactivity

Abstract: These findings expand on the current literature by showing that changes in HF-HRV predict and precede changes in circulating inflammatory cytokines in humans and may have implications for treatment of inflammatory diseases.

Cited by 29 publications

References 26 publications

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

Heart Rate Variability Predicts Treatment Outcome in Major Depression

Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial

Contact Info

Product

Resources

About