Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress?

Cardoso, Christopher; Ellenbogen, Mark A.; Serravalle, Lisa; Linnen, Anne‐Marie

doi:10.1016/j.psyneuen.2013.05.006

Cited by 67 publications

(45 citation statements)

References 20 publications

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“…Finally, although we exclusively focused on the role of dopamine in the present analysis, a full account of the neurobiology of extraversion will ultimately need to incorporate causal inf luences from other neurochemicals, most notably pertaining to the opioid and oxytocin systems (e.g., Cardoso, Ellenbogen, Serravalle, & Linnen, 2013;Carter, 2014;Depue & Morrone-Strupinsky, 2005;Hsu et al, 2013;Luo et al, 2008;Troisi et al, 2010). Given that non-additive genetic effects seem to contribute to genetic variance in extraversion (Tellegen et al, 1988;van den Berg et al, 2014), interactions within but also between neurochemical systems are likely, if not inevitable, and constitute a further challenge for future research.…”

Section: Discussionmentioning

confidence: 99%

Trait Extraversion and Dopamine Function

Wacker

Smillie

2015

Social & Personality Psych

114

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An inf luential theory within personality neuroscience suggests that trait extraversion is underpinned by individual differences in dopamine function. In a review of the relevant literature, we evaluate this theory in light of the evidence from molecular genetics, neuroimaging, and psychopharmacology. Evidence linking individual differences in extraversion with dopamine-relevant genes, structural volume of dopamine-rich brain regions (e.g., in striatal and ventral prefrontal areas), dopamine receptor availability, and frontal alpha asymmetry is mixed at best. Evidence concerning both scalp recorded (electroencephalogram) and hemodynamic (functional magnetic resonance imaging) neural responses to rewards appears somewhat more promising. Perhaps the best evidence concerns extraversiondependent responses -both neural and behavioural -to dopaminergic drugs. Future research in this area must go beyond the demonstration of theoretically consistent associations and attempt to provide more specific causal evidence for the dopamine hypothesis of extraversion. A further challenge is to expand this hypothesis to incorporate other neurobiological processes that are likely to underlie this trait.

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Section: Discussionmentioning

confidence: 99%

Trait Extraversion and Dopamine Function

Wacker

Smillie

2015

Social & Personality Psych

114

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“…It is important to note that dose-dependent effects of oxytocin in this study and others appear to be quadratic (Cardoso, Ellenbogen, Orlando, et al, 2013;Goldman et al, 2011;Hall et al, 2012), which indicates that higher doses of intranasal oxytocin may not necessarily confer greater behavioral effects. Given that oxytocin is hypothesized to play a prominent role in social affiliation and stress-coping in response to challenge (i.e., tend-and-befriend, Cardoso, Ellenbogen, Serravalle, & Linnen, 2013;Taylor et al, 2000), research in this area may benefit from a better understanding of how the oxytocinergic system is altered in disorders characterized by increased stress and social withdrawal (e.g., major depression). A better understanding of dose-dependent effects of intranasal oxytocin will also be an important point of inquiry going forward, as there is strong interest in the use of oxytocin clinically (e.g., Macdonald et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study

Cardoso

Orlando

Brown

et al. 2014

Social Neuroscience

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Intranasal oxytocin has been shown to alter self-perceptions of personality (e.g., more trusting, increased extraversion). To follow up these findings, we examined the acute effects of two doses of intranasal oxytocin (24 IU and 48 IU) on another form of self-referential cognition: autobiographical memory. Changes in autobiographical memory (personal memories for the past) could conceivably effect change in self-perception and consequently alter social behaviors. We predicted that oxytocin would increase the number of specific personal memories recalled, and promote the recall of positive social affiliation memories. Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment. Participants completed the Autobiographical Memory Test (AMT) 110 minutes later. Analyses revealed a quadratic dose-response curve for the effects of intranasal oxytocin on autobiographical memory recall. The 24 IU dose, relative to the 48 IU dose and placebo, increased the number of specific personal memories recalled and promoted the recall of social affiliation memories that were rated more positively. The lack of effect with the 48 IU dose could be due to saturation of the oxytocin receptors at higher doses. Changes in autobiographical memory may be one mechanism by which oxytocin alters prosocial worldviews.

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“…Therefore, it is necessary to study them by considering the features of the participants as discussed above. In addition to the different effects of oxytocin depending on the individual traits, a couple of recent studies demonstrated that oxytocin's social effects are context-dependent (Cardoso et al, 2013; Scheele et al, 2014). We should also take the difference in context into consideration when we investigate the effects of oxytocin.…”

Section: Discussionmentioning

confidence: 99%

Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face

et al. 2014

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The neuropeptide oxytocin plays a central role in prosocial and parental behavior in non-human mammals as well as humans. It has been suggested that oxytocin may affect visual processing of infant faces and emotional reaction to infants. Healthy male volunteers (N = 13) were tested for their ability to detect infant or adult faces among adult or infant faces (facial visual search task). Urine samples were collected from all participants before the study to measure the concentration of oxytocin. Urinary oxytocin positively correlated with performance in the facial visual search task. However, task performance and its correlation with oxytocin concentration did not differ between infant faces and adult faces. Our data suggests that endogenous oxytocin is related to facial visual cognition, but does not promote infant-specific responses in unmarried men who are not fathers.

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Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress?

Cited by 67 publications

References 20 publications

Trait Extraversion and Dopamine Function

Trait Extraversion and Dopamine Function

Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study

Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face

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