Stress-induced modulation of nociceptive responses in the rat anterior cingulate cortex

Yamashita, Hiromi; Zeredo, Jorge L.; Kaida, Kei; Kimoto, Mari; Asahina, Izumi; Toda, Kazuo

doi:10.1142/s0219635213500143

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…Quantifiable marker of oxidative stress, malondialdehyde was evaluated and data showed noticeable reduction in peripheral oxidation with no clear difference centrally. Also, exposure to stress conditioning was shown to modify neuronal changes in anterior cingulate cortex, induced anxiety or depression and enhance anterior cingulate cortex excitatory nociceptive responses [24,25]. Our histological studies showed no striking neuronal modification, behavioural results did not support presence of anxiety or depression condition and pain perception was decreased in the cage migrated mice.…”

Section: Resultscontrasting

confidence: 51%

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

Al¹,

Ko²,

Ks³

et al. 2020

Preprint

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Background Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animalbased experiment. Here, we exposed male Swiss mice to various cage sizes used across laboratories in Nigeria, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of modified biochemical metrics. ResultsThe study showed a better systemic regulation of glucose metabolism in cage migrated mice compared to cage stationed. Strikingly, peripheral oxidative stress and pain sensitivity decreased significantly in cage-to-cage migrated mice despite increased pro-inflammation mediators (IL-6 and NF-κB) which contrast the norm reported in inflammatory conditions. Interestingly, emotion-linked behaviours, neurotransmitters (serotonin, noradrenaline and GABA) and body electrolytes were not altered by cage-to-cage migration.Conclusion Taken together, these results suggest that varied size cage-to-cage migration of experimental mice could affect targeted behavioural and biomolecular parameters of pain and inflammation, thus diminishing research reproducibility, precipitating false negative/positive results and leading to poor translational outcomes.

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Section: Resultscontrasting

confidence: 51%

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

Al¹,

Ko²,

Ks³

et al. 2020

Preprint

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“…The anterior cingulate cortex is part of a forebrain network that is required for processing emotion-related behaviors, including aggression, depression, self-esteem, pain and stress (Vogt, 2005;Weber et al, 2006;Toth et al, 2012;Yamashita et al, 2013;Agroskin et al, 2014). The molecular regulation of its development, and particularly its role in corpus callosum development, are only now becoming evident (Niquille et al, 2009;Piper et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex

et al. 2015

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Transcription factors act during cortical development as master regulatory genes that specify cortical arealization and cellular identities. Although numerous transcription factors have been identified as being crucial for cortical development, little is known about their downstream targets and how they mediate the emergence of specific neuronal connections via selective axon guidance. The EMX transcription factors are essential for early patterning of the cerebral cortex, but whether EMX1 mediates interhemispheric connectivity by controlling corpus callosum formation remains unclear. Here, we demonstrate that in mice on the C57Bl/6 background EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1, cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum. EMX1 also functions as a transcriptional activator of Nrp1 expression in vitro, and overexpression of this protein in Emx1 knockout mice rescues the midline-crossing phenotype. These findings reveal a novel role for the EMX1 transcription factor in establishing cortical connectivity by regulating the interhemispheric wiring of a subpopulation of neurons within the mouse anterior cingulate cortex.

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“…Besides, the results obtained on that matter solely assessed the e®ect of repeated prenatal stress on stress-induced analgesia (Kinsley et al, 1988;Sternberg, 1999) as it is the case in many animal models in pain-related studies (Yamashita et al, 2013). To our knowledge, there is no study measuring the spontaneous stress-free nociceptive feedback in prenatally stressed adult rats using the tail°ick test.…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

Said¹,

Lakehayli²,

Battas³

et al. 2015

J. Integr. Neurosci.

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We assess the anxiety-like behavior in the open field and elevated plus maze tests and measure the nociceptive response in the tail flick test following prenatal stress exposure in adult male and female Wistar rats. In both behavioral anxiety tests, prenatal stress increased the anxiety-like behavior in male PS rats, but not in females suggesting a strong sex-dependent anxiogenic effect. The tail flick results showed a hypersensitivity to pain in male and female PS rats with a subtle gender difference. These findings suggest that prenatal stress is an important risk factor for multiple mental disorders.

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Stress-induced modulation of nociceptive responses in the rat anterior cingulate cortex

Cited by 10 publications

References 38 publications

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex

Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats

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