Stress-induced miRNAs isolated from wheat have a unique therapeutic potential in ultraviolet-stressed human keratinocyte cells

Arda, Hayati; Doğanlar, Oğuzhan

doi:10.1007/s11356-021-17039-8

Cited by 4 publications

(2 citation statements)

References 76 publications

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“…This protective effect of galangin was related to the inhibition of miR-4535 expression, thereby promoting TGFβ/Smad collagen synthesis signaling and reducing epidermal hyperplasia, wrinkle formation and skin aging. Arda and Doğanlar ( 135 ) irradiated wheat grass with UVC to obtain specific SI-WmiRs and then applied the SI-WmiRs cocktail to UVB-irradiated HaCaT cells. The results revealed that SI-WmiRs transfection prevented lipid peroxidation and oxidative stress-related DNA damage by increasing the expression of antioxidant genes and promoting DNA repair.…”

Section: Application Of Biological Therapy Targeting Ncrna In Uv-indu...mentioning

confidence: 99%

Role of non‑coding RNAs in UV‑induced radiation effects (Review)

Liang,

Zhang,

Shen

et al. 2024

Exp Ther Med

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Ultraviolet (UV) is divided into UVA (long-wave, 320-400 nm), UVB (middle-wave, 280-320 nm) and UVC (short-wave, 100-280 nm) based on wavelength. UV radiation (UVR) from sunlight (UVA + UVB) is a major cause of skin photodamage including skin inflammation, aging and pigmentation. Accidental exposure to UVC burns the skin and induces skin cancer. In addition to the skin, UV radiation can also impair visual function. Non-coding RNAs (ncRNAs) are a class of functional RNAs that do not have coding activity but can control cellular processes at the post-transcriptional level, including microRNA (miRNA), long non-coding RNA (lncRNA) and circulatory RNA (circRNA). Through a review of the literature, it was determined that UVR can affect the expression of various ncRNAs, and that this regulation may be wavelength specific. Functionally, ncRNAs participate in the regulation of photodamage through various pathways and play pathogenic or protective regulatory roles. In addition, ncRNAs that are upregulated or downregulated by UVR can serve as biomarkers for UV-induced diseases, aiding in diagnosis and prognosis assessment. Therapeutic strategies targeting ncRNAs, including the use of natural drugs and their extracts, have shown protective effects against UV-induced photodamage. In the present review, an extensive summarization of previous studies was performed and the role and mechanism of ncRNAs in UV-induced radiation effects was reviewed to aid in the diagnosis and treatment of UV-related diseases.

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Section: Application Of Biological Therapy Targeting Ncrna In Uv-indu...mentioning

confidence: 99%

Role of non‑coding RNAs in UV‑induced radiation effects (Review)

Liang,

Zhang,

Shen

et al. 2024

Exp Ther Med

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“…The cross-kingdom gene regulation by plant miRNAs was first described by Chrupek, et al and Zhang, L., et al in 2012, when Zhang, L., et al reported that rice miR-168a could survive cooking and digestion, enter the mouse sera, and function in the liver by targeting low-density lipoprotein receptor adapter protein 1 (LDLRAP1). In 2022, Hayati Arda and Oǧuzhan Doǧanlar experimentally observed an interesting phenomenon: extracted wheat miRNAs produced by wheat to aid its recovery during exposure to ultraviolet (UV) stress were beneficial for helping human keratinocyte cells recover from exposure to UV stress. Taken together, these findings indicate that plant miRNAs can use animal miRNA-induced RNA silencing machinery for cross-kingdom gene regulation and that common biological processes related to the recovery response to UV stress are mediated by the same plant miRNAs in animal and plant cells.…”

Section: Introductionmentioning

confidence: 99%

Evidence of Cross-Kingdom Gene Regulation by Plant MicroRNAs and Possible Reasons for Inconsistencies

Xu,

Zhu,

Lin

et al. 2024

J. Agric. Food Chem.

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The debate on whether cross-kingdom gene regulation by orally acquired plant miRNAs is possible has been ongoing for nearly 10 years without a conclusive answer. In this study, we categorized plant miRNAs into different groups, namely, extracellular vesicle (EV)-borne plant miRNAs, extracted plant miRNAs, herbal decoction-borne plant miRNAs, synthetic plant miRNA mimics, and plant tissue/juice-borne plant miRNAs. This categorization aimed to simplify the analysis and address the question more specifically. Our evidence suggests that EV-borne plant miRNAs, extracted plant miRNAs, herbal decoction-borne plant miRNAs, and synthetic plant miRNA mimics consistently facilitate cross-kingdom gene regulation. However, the results regarding the cross-kingdom gene regulation by plant tissue-and juice-borne plant miRNAs are inconclusive. This inconsistency may be due to variations in study methods, a low absorption rate of miRNAs and the selective absorption of plant miRNAs in the gastrointestinal tract. Overall, it is deduced that cross-kingdom gene regulation by orally acquired plant miRNAs can occur under certain circumstances, depending on factors such as the types of plant miRNAs, the delivery mechanism, and their concentrations in the plant.

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