Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

Fadda, F; Argiolas, Antonio; Melis, Maria Rosaria; Tissari, Anja H.; Onali, Pierluigi; Gl, Gessa

doi:10.1016/0024-3205(78)90207-2

Cited by 291 publications

(70 citation statements)

References 11 publications

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“…Consistent with a large number of findings (Thierry et al 1976;Fadda et al 1978;Deutch et al 1985;Abercrombie et al 1989), exposure to a single aversive stimulus such as a restraint session promoted a clear increase in extracellular DA in frontal cortex. As previously reported , CVS animals showed a higher increase in cortical DA release in response to the restraint event as compared with rats unexposed to a prior CVS regime.…”

Section: Discussionsupporting

confidence: 84%

“…In addition, a number of findings obtained from microdialysis and postmortem studies have consistently shown that mesoaccumbal and mainly mesocortical dopaminergic pathways are selectively activated by diverse types of uncontrollable aversive stimuli (Thierry et al 1976;Fadda et al 1978;Deutch et al 1985;Abercrombie et al 1989). In spite of the well known activation of these dopaminergic systems following stress, the functional role of such systems in emotional behavior remains to be established.…”

mentioning

confidence: 99%

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Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cuadra

Zurita

Gioino

et al. 2001

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 99%

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cuadra

Zurita

Gioino

et al. 2001

Neuropsychopharmacology

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“…This response pattern well agrees with preferential excitations of presumed DA neurons induced by arousing somato-sensory stimuli in awake animals, as shown both in the SNc (Freeman et al, 1985;Freeman and Bunney, 1987;Steinfels et al, 1983;Strecker et al, 1985;Schultz, 1986;Trulson, 1985) and VTA (Guarraci and Kapp, 1999;Freeman and Bunney, 1987;Kiyatkin, 1988;Horvitz et al, 1997;Schultz, 1986). These data are also consistent with large body of neurochemical data (DA metabolism, [DA] evaluated by microdialysis or electrochemistry) suggesting increased DA release, especially in cortical projections, associated with arousing and aversive stimulation (Abercrombie et al, 1989;Deutch et al, 1985;Fadda et al, 1978;Feenstra et al, 2000Feenstra et al, , 2001Kiyatkin, 1995;Le Moal and Simon, 1991;Thierry et al, 1976). It appears that this response is typical to the awake conditions when sensory effects and activation mechanisms are intact and functional; somatosensory-evoked discharges typical to most striatal neurons were greatly eliminated during general anesthesia (see Kiyatkin and Brown, 2007;West, 1996).…”

Section: Sensory Responses Of Ls and Ss Vta Neuronssupporting

confidence: 85%

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

Brown

Kiyatkin

2008

Brain Research

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Intravenous (iv) cocaine mimics salient somato-sensory stimuli in their ability to induce rapid physiological effects, which appear to involve its action on peripherally located neural elements and fast neural transmission via somato-sensory pathways. To further clarify this mechanism, single-unit recording with fine glass electrodes was used in awake rats to examine responses of ventral tegmental area (VTA) neurons, both presumed dopamine (DA) and non-DA, to iv cocaine and tail-press, a typical somato-sensory stimulus. To exclude the contribution of DA mechanisms to the observed neuronal responses to sensory stimuli and cocaine, recordings were conducted during full DA receptor blockade (SCH23390+eticloptide).Iv cocaine (0.25 mg/kg delivered over 10 s) induces significant excitations of ~63% of long-spike (presumed DA) and ~70% of short-spike (presumed non-DA) VTA neurons. In both subgroups, neuronal excitations occurred with short latencies (4-8 s), peaked at 10-20 s (30-40% increase over baseline) and disappeared at 30-40 s after the injection onset. Most long-(67%) and short-spike (89%) VTA neurons also showed phasic responses to tail-press (5-s). All responsive long-spike cells were excited by tail-press; excitations were very rapid (peak at 1 s) and strong (100% rate increase over baseline) but brief (2-3 s). In contrast, both excitations (60%) and inhibitions (29%) were seen in short-spike cells. These responses were also rapid and transient, but excitations of short-spike units were more prolonged and sustained (10-15 s) than in long-spike cells.These data suggest that in awake animals iv cocaine, like somato-sensory stimuli, rapidly and transiently excites VTA neurons of different subtypes. Therefore, along with direct action on specific brain substrates, central effects of cocaine may occur via indirect mechanism, involving peripheral neural elements, visceral sensory nerves and rapid neural transmission. Via this mechanism, cocaine, like somato-sensory stimuli, can rapidly activate DA neurons and induce phasic DA release, creating the conditions for DA accumulation by a later occurring and prolonged direct inhibiting action on DA uptake. By providing a rapid neural signal and triggering transient neural activation, such a peripherally driven action might play a crucial role in the sensory effects of COC, thus contributing to learning and development of drug-taking behavior.

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“…Both stress and psychostimulants activate the hypothalamic-pituitaryadrenal (HPA) axis (Knich and Eisenberg, 1979;Moldow and Fischman, 1987;Rivier and Vale, 1987) and dopamine (DA) neurotransmission in limbic regions (Fadda et al, 1978;Deutch and Roth, 1990;Sorg and Kalivas, 1991;Imperato et al, 1992;Hamamura and Fibiger, 1993). Further, stress and cocaine lead to common intracellular adaptations within the mesolimbic DA system (Saal et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Kosten

Zhang

Kehoe

2005

Neuropsychopharmacol

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Previously, we demonstrated that the early life stress of neonatal isolation facilitates acquisition of cocaine and food self-administration in adult female rats. We now test whether it enhances responding for these reinforcers after operant performance is established. Adult female rats were derived from litters that were either subjected to neonatal isolation (1 h/day isolation; postnatal days 2-9) or were nonhandled and assigned to one of two experiments. In Experiment 1, female rats well trained to self-administer cocaine were tested under a fixed-ratio 3 (FR3) schedule with several cocaine doses (0.0625-1.0 mg/kg/infusion) and under a progressive-ratio (PR) schedule (0, 0.5, and 1.0 mg/kg/infusion cocaine). In Experiment 2, female rats well trained to respond for food reinforcers under an FR15 schedule were tested under two PR schedules. Results show that neonatal isolation enhanced responding for cocaine under both schedules of reinforcement and increased responding for food under a PR schedule of reinforcement. These data extend our previous acquisition study in female rats to show that neonatal isolation enhances responding under maintenance conditions. These enduring behavioral changes may relate to the ability of neonatal isolation to increase striatal dopamine responses to psychostimulants, effects we showed previously in infant and juvenile rats.

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Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

Cited by 291 publications

References 11 publications

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

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